Association of magnesium depletion score with serum anti-aging protein Klotho in the middle-aged and older populations DOI Creative Commons

Zhijie Zhuang,

Shan Huang,

Yingzhu Xiong

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 27, 2025

Background Magnesium deficiency and low levels of the anti-aging protein Klotho have been independently associated with various age-related diseases. The Depletion Score (MDS) is recognized as a more valuable reliable predictor body magnesium status than traditional clinical markers such serum urine magnesium. However, relationship between remains unexplored. This study aimed to investigate association depletion, quantified by MDS, in US adults. Methods We analyzed data from 11,387 participants aged 40–79 years National Health Nutrition Examination Survey (NHANES) 2007–2016. Participants were divided into three groups based on MDS: (0–1 points), middle (2 high (3–5 reflecting cumulative risks depletion derived diuretic use, proton pump inhibitors, renal function, alcohol intake. Serum measured using validated ELISA assay. Sample-weighted multivariable linear regression models used examine MDS levels, adjusting for age, sex, race, socioeconomic status, lifestyle factors (smoking, use), parameters (body mass index, blood pressure, lipid levels), energy Results weighted average concentrations decreased significantly across (low: 864.50, middle: 805.67, high: 755.02 pg./mL; p < 0.0001). After full adjustment, compared group, had lower ( β = −35.49, 95% CI: −62.29 −8.69; −64.82, −115.30 −14.34, respectively; trend 0.003). inverse remained consistent subgroups, particularly strong relationships observed individuals BMI <25, current smokers, those income. Conclusion provides novel evidence an new indicator large, representative sample These findings suggest that monitoring via could help identify at risk accelerated aging, prompting interventions dietary adjustments or supplementation high-risk populations. Further research warranted elucidate mechanisms underlying this its implications

Language: Английский

The Role of Magnesium in the Pathogenesis of Metabolic Disorders DOI Open Access
Marta Pelczyńska, Małgorzata Moszak, Paweł Bogdański

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(9), P. 1714 - 1714

Published: April 20, 2022

Magnesium (Mg) is an essential nutrient for maintaining vital physiological functions. It involved in many fundamental processes, and Mg deficiency often correlated with negative health outcomes. On the one hand, most western civilizations consume less than recommended daily allowance of Mg. other a growing body evidence has indicated that chronic hypomagnesemia may be implicated pathogenesis various metabolic disorders such as overweight obesity, insulin resistance (IR) type 2 diabetes mellitus (T2DM), hypertension (HTN), changes lipid metabolism, low-grade inflammation. High intake diet and/or supplementation seems to prevent complications. The protective action include limiting adipose tissue accumulation, improving glucose enhancing endothelium-dependent vasodilation, normalizing profile, attenuating inflammatory processes. Thus, it currently plays important role developing associated although more randomized controlled trials (RCTs) evaluating strategies are needed. This work represents review synthesis recent data on disorders.

Language: Английский

Citations

82
Magnesium Depletion Score and Metabolic Syndrome in US Adults: Analysis of NHANES 2003 to 2018 DOI Creative Commons
X. Wang, Zhaohao Zeng, Xinyu Wang

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 109(12), P. e2324 - e2333

Published: Feb. 14, 2024

Abstract Context The association between magnesium status and metabolic syndrome (MetS) remains unclear. Objective This study aimed to examine the relationship kidney reabsorption-related depletion score (MDS) MetS among US adults. Methods We analyzed data from 15 565 adults participating in National Health Nutrition Examination Survey (NHANES) 2003 2018. was defined according Cholesterol Education Program's Adult Treatment Panel III report. MDS is a scoring system developed predict of deficiency that fully considers pathophysiological factors influencing kidneys' reabsorption capability. Weighted univariate multivariable logistic regression were used assess MetS. Restricted cubic spline (RCS) analysis conducted characterize dose-response relationships. Stratified analyses by sociodemographic lifestyle also performed. Results In both analyses, higher significantly associated with increased odds Each unit increase approximately 30% risk for MetS, even after adjusting confounding (odds ratio 1.31; 95% CI, 1.17-1.45). RCS graphs depicted linear across range. positive correlation remained consistent various population subgroups exhibited no significant interaction age, sex, race, adiposity, smoking status, or alcohol consumption. Conclusion Higher urinary loss as quantified may be an independent factor adults, irrespective behavioral factors. Optimizing nutritional could potentially confer benefits patients

Language: Английский

Citations

19
Magnesium and Hypertension in Old Age DOI Open Access
Ligia J. Domínguez, Nicola Veronese, Mario Barbagallo

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 13(1), P. 139 - 139

Published: Dec. 31, 2020

Hypertension is a complex condition in which various actors and mechanisms combine, resulting cardiovascular cerebrovascular complications that today represent the most frequent causes of mortality, morbidity, disability, health expenses worldwide. In last decades, there has been an exceptional amount experimental, epidemiological, clinical studies confirming close relationship between magnesium deficit high blood pressure. Multiple may help to explain bulk evidence supporting protective effect against hypertension its complications. increases sharply with advancing age, hence older persons are those affected by negative consequences. They also more frequently at risk deficiency multiple mechanisms, may, least part, higher frequency long-term The for favorable on emphasizes importance broadly encouraging intake foods such as vegetables, nuts, whole cereals legumes, optimal dietary sources magnesium, avoiding processed food, very poor other fundamental nutrients, order prevent hypertension. some cases, when diet not enough maintain adequate status, supplementation be benefit shown well tolerated.

Language: Английский

Citations

86
The relevance of magnesium homeostasis in COVID-19 DOI Creative Commons
Valentina Trapani, Aaron J. Rosanoff,

Shadi Baniasadi

et al.

European Journal of Nutrition, Journal Year: 2021, Volume and Issue: 61(2), P. 625 - 636

Published: Oct. 23, 2021

Abstract Purpose In less than one and a half year, the COVID-19 pandemic has nearly brought to collapse our health care economic systems. The scientific research community concentrated all possible efforts understand pathogenesis of this complex disease, several groups have recently emphasized recommendations for nutritional support in patients. scoping review, we aim at encouraging deeper appreciation magnesium clinical nutrition, view vital role numerous links between pathophysiology SARS-CoV-2 infection magnesium-dependent functions. Methods By searching PubMed Google Scholar from 1990 date, review existing evidence experimental studies on chronic non-communicable diseases infectious diseases, focus recent reports alterations homeostasis patients their association with disease outcomes. Importantly, conduct census ongoing trials specifically dedicated disclosing COVID-19. Results Despite many methodological limitations, data seem corroborate an deranged COVID-19, call further better explore prophylactic or therapeutic potential supplementation. Conclusion We propose reconsider relevance magnesium, frequently overlooked practice. Therefore, magnesemia should be monitored and, case imbalanced homeostasis, appropriate regimen supplementation might contribute protect against infection, reduce severity symptoms facilitate recovery after acute phase.

Language: Английский

Citations

73
Magnesium Depletion Score (MDS) Predicts Risk of Systemic Inflammation and Cardiovascular Mortality among US Adults DOI Creative Commons
Lei Fan,

Xiangzhu Zhu,

Aaron J. Rosanoff

et al.

Journal of Nutrition, Journal Year: 2021, Volume and Issue: 151(8), P. 2226 - 2235

Published: April 23, 2021

Language: Английский

Citations

61
Association of Magnesium Depletion Score With Cardiovascular Disease and Its Association With Longitudinal Mortality in Patients With Cardiovascular Disease DOI Creative Commons
Liu Ye, Cheng Zhang, Qin Duan

et al.

Journal of the American Heart Association, Journal Year: 2023, Volume and Issue: 12(18)

Published: Sept. 8, 2023

Background Dietary magnesium and serum play an important part in cardiovascular disease (CVD). However, the association between depletion score (MDS) CVD development prognosis remains unclear. This analysis examines cross-sectional relationship MDS CVD, longitudinal all-cause mortality individuals with CVD. Methods Results In all, 42 711 were selected from National Health Nutrition Examination Survey, including 5015 subjects The total individual CVDs was examined using survey-weighted multiple logistic regression analysis. Among 5011 patients 2285 927 participants recorded deaths, respectively. We applied Cox proportional hazards analyses to investigate impact of on group had higher levels than non-CVD groups. After controlling all confounding factors, 2 ≥3 odds specific those 0. Besides, each 1-unit increase strongly related risk stable significant subgroups. fully adjusted model indicated that high MDS, irrespective as a categorical or continuous variable, significantly associated elevated deaths. Conclusions is vital factor for prevalence

Language: Английский

Citations

30
Magnesium Deficiency and Cardiometabolic Disease DOI Open Access
Rémi Fritzen, Amy Davies, Miriam Veenhuizen

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2355 - 2355

Published: May 17, 2023

Magnesium (Mg2+) has many physiological functions within the body. These include important roles in maintaining cardiovascular functioning, where it contributes to regulation of cardiac excitation-contraction coupling, endothelial functioning and haemostasis. The haemostatic Mg2+ impact upon both protein cellular arms coagulation. In this review, we examine how homeostasis is maintained body highlight various molecular attributed system. addition, describe nutritional and/or disease-associated magnesium deficiency, seen some metabolic conditions, potential influence vascular outcomes. Finally, also for supplements be employed prevention treatment disorders management cardiometabolic health.

Language: Английский

Citations

28
Relationship between the Magnesium Depletion Score and All-cause and Cardiovascular Mortality among Asthma Patients: A Study Based on the NHANES Population from 2005--2018 DOI Creative Commons

Lanxin Fan,

Xue‐Qing Gong, Hong-Ling Jia

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127602 - 127602

Published: Jan. 17, 2025

Language: Английский

Citations

1
The kidney reabsorption-related magnesium depletion score is associated with cardiovascular disease and longitudinal mortality in diabetic kidney disease patients DOI Creative Commons
Zhengxi Zhou, Xiaotian Yao

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 29, 2025

The kidney reabsorption is essential for maintaining magnesium homeostasis. This study aims to explore the relationship between reabsorption-related depletion score (MDS) and occurrence of cardiovascular disease (CVD) prognosis in diabetic (DKD) patients. We included 3199 DKD patients from National Health Nutrition Examination Survey (NHANES) database, including 1072 CVD Weighted logistic regression analysis was used MDS CVD. COX proportional hazards mortality. Stratified further validate. Finally, we assessed predictive accuracy on survival outcomes using time-dependent receiver operating characteristic (ROC) curve analysis. Survey-weighted multiple revealed that ≥ 3, incidence increased by 371%. During follow-up period (median 87 months), 1373 all-cause deaths (497 deaths) were recorded. In patients, mortality 78% (P < 0.001) cardiac 76% = 0.08). Consistent results also shown when stratified age, sex, race, marital status, intake. area under (AUC) values predicting 1-,2-,3-,4-, 5-year 0.86, 0.66, 0.59, 0.57, 0.55, 0.9, 0.67, 0.62, 0.58, 0.56 MDS, reabsorption-related, positively correlated with longitudinal

Language: Английский

Citations

1
Dietary Approaches to Stop Hypertension (DASH): potential mechanisms of action against risk factors of the metabolic syndrome DOI
Masoumeh Akhlaghi

Nutrition Research Reviews, Journal Year: 2019, Volume and Issue: 33(1), P. 1 - 18

Published: July 30, 2019

Abstract The metabolic syndrome is a cluster of disorders dominated by abdominal obesity, hypertriacylglycerolaemia, low HDL-cholesterol, high blood pressure and fasting glucose. Diet modification safe effective way to treat the syndrome. Dietary Approaches Stop Hypertension (DASH) dietary pattern rich in fruits, vegetables low-fat dairy products, meats sweets. DASH provides good amounts fibre, K, Ca Mg, limited quantities total fat, saturated cholesterol Na. Although was initially designed for prevention or control hypertension, using diet has other benefits. In present review, effect each component on risk factors discussed. Due fat fibre content, individuals are less prone overweight obesity possess lower concentrations LDL-cholesterol although changes TAG HDL-cholesterol have been significant available evidence this regard still inconclusive. Moreover, fruit provide great Mg all which shown reduce pressure. antioxidants also correcting glucose insulin abnormalities. Evidence provided from cross-sectional investigations, cohort studies randomised controlled trials, and, where available, published meta-analyses. Mechanisms described according human case lack evidence, animal cell culture investigations.

Language: Английский

Citations

76