A systematic review on the association between exposure to air particulate matter during pregnancy and the development of hypertensive disorders of pregnancy and gestational diabetes mellitus

Reviews on Environmental Health, Journal Year: 2023, Volume and Issue: unknown

Published: May 4, 2023

Abstract Particulate matter (PM) is considered an intrauterine toxin that can cross the blood-placental barrier and circulate in fetal blood, affecting development, implicating placental inflammation, oxidative damage. However, relationship between PM exposure adverse pregnancy outcomes still unclear our aim was to systematically review toxicological evidence on link during development of gestational diabetes mellitus or hypertensive disorders pregnancy, including hypertension pre-eclampsia. PubMed Science Direct were searched until January 2022. Of 204 studies identified, 168 excluded. The remaining articles assessed full-text, after evaluation, 27 included review. Most showed association hypertension, systolic diastolic blood pressure, pre-eclampsia, mellitus. These results should be interpreted with caution due heterogeneity baseline concentrations, which ranged from 3.3 μg/m 3 85.9 21.8 92.2 , respectively for PM2.5 PM10. Moreover, critical periods not consistent among studies, five out ten observational reporting second trimester as period twelve first Overall, findings support outcomes, highlighting need further research identify underlying mechanisms.

Language: Английский

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Cohort profile: the Environmental Reproductive and Glucose Outcomes (ERGO) Study (Boston, Massachusetts, USA) — a prospective pregnancy cohort study of the impacts of environmental exposures on parental cardiometabolic health

BMJ Open, Journal Year: 2024, Volume and Issue: 14(5), P. e079782 - e079782

Published: May 1, 2024

Purpose Pregnancy and the postpartum period are increasingly recognised as sensitive windows for cardiometabolic disease risk. Growing evidence suggests environmental exposures, including endocrine-disrupting chemicals (EDCs), associated with an increased risk of pregnancy complications that long-term However, impact perinatal EDC exposure on subsequent post-pregnancy is less understood. The Environmental Reproductive Glucose Outcomes (ERGO) Study was established to investigate associations exposures during parental health. Participants Pregnant individuals aged ≥18 years without pre-existing diabetes were recruited at <15 weeks gestation from Boston, Massachusetts area hospitals. completed ≤4 prenatal study visits (median: 12, 19, 26, 36 gestation) 1 visit 9 weeks), which we collected biospecimens, health histories, demographic behavioural data, vitals anthropometric measurements. a fasting 2-hour 75 g oral glucose tolerance test. Clinical data abstracted electronic medical records. Ongoing (as 2024) extended follow-up occur annually following similar collection protocols. Findings date We enrolled 653 unique pregnancies retained 633 through delivery. had mean age 33 years, 10% (n=61) developed gestational 8% (n=50) pre-eclampsia. Participant urinary phthalate metabolite concentrations glycaemic biomarkers quantified. To date, studies within ERGO found higher phthalates mixtures, separately, radioactive ambient particulate matter, adverse outcomes. Additionally, certain personal care products used in pregnancy, notably hair oils, concentrations, earlier delivery lower birth weight. Future plans work will leverage longitudinal outcomes, questionnaires, banked biospecimens paediatric Study.

Language: Английский

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Exposure to Radon and Ambient Particle Radioactivity During Pregnancy and Adverse Maternal, Fetal and Perinatal Outcomes: The Current Literature and Potential Mechanisms

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120272 - 120272

Published: Oct. 1, 2024

Language: Английский

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Prenatal exposure to ambient particle radioactivity and fetal growth in Eastern Massachusetts

Air Quality Atmosphere & Health, Journal Year: 2023, Volume and Issue: 16(4), P. 805 - 815

Published: Jan. 27, 2023

Language: Английский

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Identification of differential metabolites using untargeted metabolomics between gestational diabetes and normal pregnant women

International Journal of Gynecology & Obstetrics, Journal Year: 2022, Volume and Issue: 159(3), P. 903 - 911

Published: May 6, 2022

Language: Английский

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