Integrated approaches for immunotoxicity risk assessment: challenges and future directions DOI Creative Commons

Vaisali Chandrasekar,

Anu Jayanthi Panicker,

Avishek Dey

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Oct. 29, 2024

The integration of immunotoxicity data into chemical risk assessment paradigms is essential for comprehensively evaluating the potential health hazards posed by exposures. This review provides a comprehensive overview methodologies, challenges, and future directions integrating frameworks. It discusses fundamental principles immunotoxicology its relevance to assessment, highlighting critical roles immune system in defense against harmful agents. Next, we explore traditional frameworks, including exposure hazard identification, dose–response characterization, need incorporating endpoints enhance characterization estimation. Subsequently, delve modelling immunotoxicity, elucidating principles, methods, case studies illustrating relationships extrapolation from animal humans. Furthermore, discuss focusing on identification immunotoxic hazards, evaluation endpoints, utilization immunological biomarkers assessment. We then examine cumulative strategies, presenting conceptual framework assessing risks multiple exposures methods different chemicals. Lastly, emerging trends high-throughput screening assays, omics technologies, computational modelling, alternative testing along with regulatory implications research needs. valuable insights researchers, regulators, stakeholders involved public protection, facilitating development evidence-based strategies safeguarding human associated

Language: Английский

The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective DOI Creative Commons
Andi Alijagić, Damir Suljević, Muhamed Fočak

et al.

Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108736 - 108736

Published: May 10, 2024

The presence of microplastics (MPs) is increasing at a dramatic rate globally, posing risks for exposure and subsequent potential adverse effects on human health. Apart from being physical objects, MP particles contain thousands plastic-associated chemicals (i.e., monomers, chemical additives, non-intentionally added substances) captured within the polymer matrix. These are often migrating MPs can be found in various environmental matrices food chains; health effects. In addition to attributes MPs, plastic surfaces effectively bind exogenous chemicals, including pollutants (e.g., heavy metals, persistent organic pollutants). Therefore, act as vectors pollution across air, drinking water, food, further amplifying posed by exposure. Critically, fragmentation plastics environment increases risk interactions with cells, available leach adsorb transfer pollutants. This review proposes so-called triple nexus approach comprehensively map existing knowledge interconnected particles, Based data, there large gap regard cumulative nexus. Each component known induce genotoxicity, inflammation, endocrine disruption, but about long-term inter-individual lacking. Furthermore, not readily excreted organisms after ingestion they have been accumulated blood, cardiac tissue, placenta, etc. Even though number studies MPs-associated impacts rapidly, this underscores that pressing necessity achieve an integrated assessment MPs' order address future gaps.

Language: Английский

Citations

40
Public Health Risks of PFAS-Related Immunotoxicity Are Real DOI Creative Commons
Abigail P. Bline, Jamie C. DeWitt, Carol F. Kwiatkowski

et al.

Current Environmental Health Reports, Journal Year: 2024, Volume and Issue: 11(2), P. 118 - 127

Published: March 25, 2024

Abstract Purpose of Review The discovery per- and polyfluoroalkyl substances (PFAS) in the environment humans worldwide has ignited scientific research, government inquiry, public concern over numerous adverse health effects associated with PFAS exposure. In this review, we discuss use immunotoxicity data regulatory clinical decision-making contexts question whether recent efforts adequately account for decision-making. Recent Findings Government academic reviews confirm strongest human evidence is reduced antibody production response to vaccinations, particularly tetanus diphtheria. However, events, such as economic analysis supporting proposed national primary drinking water regulations monitoring recommendations, indicate a failure incorporate these into decisions. Summary To be more protective health, recommend using all relevant inform current future PFAS-related chemical risk assessment regulation. Biological measures immune system effects, levels vaccination, should used valid informative markers outcomes risks Routine toxicity testing expanded include evaluations adult developing organisms. addition, recommendations PFAS-exposed individuals communities revisited strengthened provide guidance on incorporating other actions that can taken protect against outcomes.

Language: Английский

Citations

23
Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages DOI Creative Commons
Chengyu Hu, Sheng Yang, Tianyi Zhang

et al.

Environment International, Journal Year: 2024, Volume and Issue: 184, P. 108415 - 108415

Published: Jan. 8, 2024

An increasing number of harmful environmental factors are causing serious impacts on human health, and there is an urgent need to accurately identify the toxic effects mechanisms these factors. However, traditional toxicity test methods (e.g., animal models cell lines) often fail provide accurate results. Fortunately, organoids differentiated from stem cells can more accurately, sensitively specifically reflect body. They also suitable for specific studies frequently used in toxicology nowadays. As a combination organ-on-a-chip technology, organoids-on-a-chip has great potential toxicology. It controllable physicochemical microenvironment not easy be contaminated. higher homogeneity size shape organoids. In addition, it achieve vascularization exchange nutrients metabolic wastes time. Multi-organoids-chip simulate interactions different organs. These advantages facilitate better function maturity organoids, which make up shortcomings common certain extent. This review firstly discussed limitations testing platforms, leading introduction new platforms: organoids-on-a-chip. Next, applications were summarized prospected. Since platforms have been sufficiently considered previous literature, we particularly emphasized them. Finally, this opportunities challenges faced by organoids-on-a-chip, with expectation that readers will gain deeper understanding their value field

Language: Английский

Citations

18
Per- and Polyfluoroalkyl Substances and Female Health Concern: Gender-based Accumulation Differences, Adverse Outcomes, and Mechanisms DOI
Xin Li, Minmin Hou, Feng Zhang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The deleterious health implications of perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely recognized. Females, in contrast to males, exhibit unique pathways for PFAS exposure excretion, leading complex outcomes. status females is largely influenced by hormone-related processes. have been reported be associated with various aspects female health, including reproductive system disorders pregnancy-related diseases. In this article, we provide insights into the correlations between female-prevalent Current epidemiological toxicological evidence has demonstrated that adverse effects on primarily attributed disruption hypothalamic-pituitary-gonadal (HPG) axis hormonal homeostasis. However, these findings do not sufficiently elucidate intricate associations specific Furthermore, autoimmune disorders, another category more prevalent women compared men, require additional investigation. Immune biomarkers pertinent observed exposure, although insufficient substantiate relations. Further thorough exploration encompassing studies essential elucidating inherent influence human pathologies. Additionally, comprehensive investigations issues beyond their functions essential.

Language: Английский

Citations

2
Unveiling the emerging concern of per- and polyfluoroalkyl substances (PFAS) and their potential impacts on estuarine ecosystems DOI
Amit Hasan Anik,

Md. Samium Basir,

Maisha Binte Sultan

et al.

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 212, P. 117554 - 117554

Published: Jan. 20, 2025

Language: Английский

Citations

2
Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length DOI
Liang Tang, Wenhui Qiu, Shuwen Zhang

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(15), P. 6139 - 6149

Published: April 5, 2023

Previous studies have reported the immunotoxicity of per- and polyfluoroalkyl substances (PFASs), but it remains a significant challenge to assess over 10,000 distinct PFASs registered in distributed structure-searchable toxicity (DSSTox) database. We aim reveal mechanisms different hypothesize that PFAS is dependent on carbon chain length. Perfluorobutanesulfonic acid (PFBA), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) representing lengths (4-9) at environmentally relevant levels strongly reduced host's antibacterial ability during zebrafish's early-life stage. Innate adaptive immunities were both suppressed after exposures, exhibiting induction macrophages neutrophils expression immune-related genes indicators. Interestingly, PFAS-induced immunotoxic responses positively correlated Moreover, activated downstream toll-like receptor (TLR), uncovering seminal role TLR immunomodulatory effects. Myeloid differentiation factor 88 (MyD88) morpholino knock-down experiments MyD88 inhibitors alleviated PFASs. Overall, comparative results demonstrate differences due length zebrafish, providing new insights into prediction classification mode toxic action based

Language: Английский

Citations

34
A review on structural mechanisms of protein-persistent organic pollutant (POP) interactions DOI
Nupur Nagar,

Harshi Saxena,

Aakanksha Pathak

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 332, P. 138877 - 138877

Published: May 8, 2023

Language: Английский

Citations

25
PFASs: What can we learn from the European Human Biomonitoring Initiative HBM4EU DOI Creative Commons
Maria Uhl, Greet Schoeters, Eva Govarts

et al.

International Journal of Hygiene and Environmental Health, Journal Year: 2023, Volume and Issue: 250, P. 114168 - 114168

Published: April 15, 2023

Per- and polyfluoroalkyl substances (PFASs) were one of the priority substance groups selected which have been investigated under ambitious European Joint programme HBM4EU (2017-2022). In order to answer policy relevant questions concerning exposure health effects PFASs in Europe several activities developed namely i) synthesis HBM data generated prior by developing new platforms, ii) development a Quality Assurance/Quality Control Program covering 12 biomarkers PFASs, iii) aligned harmonized human biomonitoring studies PFASs. addition, some cohort (on mother-child exposure, occupational hexavalent chromium) initiated, literature researches on risk assessment mixtures PFAS, effect performed. The Aligned Studies internal reference levels for 1957 teenagers aged 12-18 years. results showed that serum 14.3% exceeded 6.9 μg/L corresponds EFSA guideline value tolerable weekly intake (TWI) 4.4 ng/kg (PFOA, PFOS, PFNA PFHxS). Northern Western Europe, 24% this level. most sources identified drinking water foods (fish, eggs, offal locally produced foods). also revealed very high workers (P95: 192 chrome plating facilities), highlighting importance monitoring specific workplaces. environmental contaminated hotspots causing population identified. conclusion, frequent evidenced strongly suggests need take all possible measures prevent further contamination population, addition adopting remediation hotspot areas, protect environment. findings support restriction whole group Further, research definition additional toxicological dose-effect relationship values more compounds is needed.

Language: Английский

Citations

24
Forever Pesticides: A Growing Source of PFAS Contamination in the Environment DOI Creative Commons
Nathan Donley, Caroline Cox,

K. P. Bennett

et al.

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(7)

Published: July 1, 2024

Environmental contamination by fluorinated chemicals, in particular chemicals from the per- and polyfluoroalkyl substances (PFAS) class, has raised concerns around globe because of documented adverse impacts on human health, wildlife, ecosystem quality. Recent studies have indicated that pesticide products may contain a variety meet PFAS definition, including active ingredients themselves. Given pesticides are some most widely distributed pollutants across world, legacy addition into could be widespread wide-ranging implications agriculture food water contamination, as well presence rural environments.

Language: Английский

Citations

16
Integrated evidence of transcriptional, metabolic, and intestinal microbiota changes in Ruditapes philippinarum due to perfluorooctanoic acid-induced immunotoxicity DOI
Fengling Li,

Xiuqiong Gong,

Zhou Yang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 916, P. 170341 - 170341

Published: Jan. 23, 2024

Language: Английский

Citations

13