Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 97, P. 12 - 20
Published: Nov. 4, 2023
Language: Английский
Redox Biology, Journal Year: 2024, Volume and Issue: 77, P. 103375 - 103375
Published: Oct. 2, 2024
Language: Английский
Citations
5
Journal of Translational Internal Medicine, Journal Year: 2024, Volume and Issue: 12(6), P. 540 - 542
Published: Dec. 1, 2024
Language: Английский
Citations
4
Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120176 - 120176
Published: Feb. 1, 2025
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 1, 2025
Oral squamous cell carcinoma (OSCC) is frequently observed as the predominant malignancy affecting oral cavity, with distant metastasis greatly treatment and long-term outlook for individuals OSCC. Immune checkpoint inhibitors are a highly promising cancer strategy currently available, but they only successful small fraction of Due to insufficient understanding immune escape mechanisms in OSCC, coupled disappointing outcomes patients heterogeneous metastatic diseases, there an urgent need further exploration target therapy strategies. This review discusses by which OSCC cells evade surveillance attack, focusing on four aspects: metastasis-initiating cells, increased suppression, dormant stromal crosstalk during metastasis. Additionally, we explore new areas In summary, our investigation offers fresh perspectives relationship between tumor microenvironment molecules, highlighting importance overcoming evasion development novel therapies manage enhance patient outcomes.
Language: Английский
Citations
0
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 4813 - 4830
Published: April 1, 2025
Pancreatic cancer (PCA) is a highly malignant tumor with 5-year survival rate of <10%. It characterized as cold an immunosuppressive microenvironment. Liver dysfunction due to biliary obstruction can affect the inflammation index, indicator immune status. Adjusting indices for liver function may enhance their clinical utility predicting overall (OS) in PCA patients. Resected cases were selected using specific criteria. indicators identified by Spearman's analysis integrated into covariance refine indices, including modified neutrophil-to-lymphocyte ratio (mNLR), platelet-to-lymphocyte (mPLR), lymphocyte-to-monocyte (mLMR), systemic immune-inflammation index (mSII), and C-reactive protein (mCRP). These clinicopathological factors analyzed identify independent OS predictors. A nomogram was developed compared primary inflammation-based model calibration curves, decision curve (DCA), concordance (C-index). direct bilirubin (DBIL), indirect (IBIL), alanine aminotransferase (ALT), aspartate (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin (ALB) indices. In patients, higher mNLR, mSII, CA19-9, T stage, N stage associated worse OS, while mLMR or PNI levels correlated better OS. Vascular invasion predicted poor whereas chemotherapy improved The model's surpassed that model. incorporating demonstrated superior utility. recommended prognostic prediction, especially patients obstruction. For advanced staging poorly differentiated tumors, intraoperative margin nanoknife ablation timely postoperative adjuvant are prognosis.
Language: Английский
Citations
0
Journal of Clinical Personalized Medicine, Journal Year: 2025, Volume and Issue: 04(02), P. 925 - 935
Published: Jan. 1, 2025
Language: Английский
Citations
0
World Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 16, 2025
This study examines the cellular heterogeneity of epithelial cells within pancreatic ductal adenocarcinoma (PDAC) and their contributions to tumor progression, metastasis, immunosuppressive interactions using single-cell RNA sequencing. Single-cell RNA-sequencing data from two datasets (GSE154778 GSE158356) were integrated Harmony algorithm, followed by quality control, clustering, differential gene expression analysis. Distinct subpopulations identified, profiles analyzed. To assess malignancy these subpopulations, copy number variation (CNV) analysis trajectory conducted. Additionally, intercellular communication was examined CellChat platform. The revealed pronounced among PDAC cells, with specific exhibiting distinct roles in proliferation, extracellular matrix remodeling, metastatic dissemination. Subpopulations 4 6 characterized increased CNV levels a more malignant phenotype, suggesting an enhanced capacity for metastasis. analysis, along CellChat, mapped temporal evolution identifying key regulatory genes such as DCBLD2 JUN. A prognostic model incorporating five genes, including KLF6, developed demonstrated strong predictive accuracy patient outcomes. Notably, KLF6 emerged critical marker associated immune modulation, particularly through M2 macrophages. highlights modulation. Through transcriptomic analyses, we identified varying potentials microenvironment. Among these, regulator modulation Our findings emphasize significance cell shaping cancer progression. These insights provide foundation future investigations into novel markers therapeutic strategies.
Language: Английский
Citations
0
Human Gene, Journal Year: 2025, Volume and Issue: unknown, P. 201410 - 201410
Published: April 1, 2025
Language: Английский
Citations
0
Cancer Letters, Journal Year: 2023, Volume and Issue: 579, P. 216456 - 216456
Published: Nov. 1, 2023
Pancreatic cancer remains one of the deadliest cancers with extremely high mortality rate, and number cases is expected to steadily increase time. refractory conventional treatment options, like chemotherapy radiotherapy, commercialized immunotherapeutics, owing its immunosuppressive desmoplastic phenotype. Due these reasons, development an innovative option that can overcome challenges posed by pancreatic tumor microenvironment (TME) in urgent need. The present review aims summarize evolution oncolytic adenovirus (oAd) engineering usage as therapeutics (either monotherapy or combination therapy) over last decade hurdles instigate a potent antitumor effect against cancer.
Language: Английский
Citations
10
Medicine, Journal Year: 2024, Volume and Issue: 103(2), P. e36186 - e36186
Published: Jan. 12, 2024
Inflammation plays a critical role in vertebral fractures. However, there is lack of sufficient evidence regarding the prognostic significance systemic immuno-inflammatory index (SII), novel marker inflammation, patients with In this study, we aimed to assess predictive value SII critically ill The data were from Medical Information Mart for Intensive Care III (MIMIC-III) version 1.4 and Wenzhou Hospital Traditional Chinese Medicine. cutoff values determined using receiver operating characteristic curve, subjects grouped accordingly. clinical outcome measured was mortality within 30 days, 90 or 1 year. following formula used calculate SII: = (platelet count) × (neutrophil count)/ (lymphocyte count). Cox proportional-hazard models employed relationship between survival. Additionally, propensity score matching analysis COX utilized examine association survival outcomes. Pearson correlation test confirmed T-values by bone mineral density pain indicator. A total 354 finally included MIMIC-III univariate analysis, 30-day mortality, ≥ 3164 group, hazard ratio (HR) (95% confidence interval) 1.71 (1.01, 2.94). After adjusting age, gender, race, anion gap, creatinine, systolic blood pressure (SBP), DBP MBP, SOFA, acute physiologic III, chronic kidney disease, SAPS II, found be an independent significant risk factor death (HR 1.85, 95% CI: 1.06–3.24, P .0315). similar trend observed 90-day 1-year mortality. Propensity scores further prognosis patients. Our validation results consistent it. Besides, study findings revealed that predictor This indicates can serve as reliable easily accessible indicator newly diagnosed
Language: Английский
Citations
2