Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1109 - 1109
Published: Sept. 13, 2024
Oxidative
stress
is
the
result
of
imbalance
between
reactive
oxygen
and
nitrogen
species
(RONS),
which
are
produced
by
several
endogenous
exogenous
processes,
antioxidant
defenses
consisting
molecules
that
protect
biological
systems
from
free
radical
toxicity.
a
major
factor
in
aging
process,
contributing
to
accumulation
cellular
damage
over
time.
biomolecules,
leads
DNA
alterations,
lipid
peroxidation,
protein
oxidation,
mitochondrial
dysfunction
resulting
senescence,
immune
system
tissue
dysfunctions,
increased
susceptibility
age-related
pathologies,
such
as
inflammatory
disorders,
cardiovascular
neurodegenerative
diseases,
diabetes,
cancer.
stress-driven
mutations,
or
methylation
histone
modification,
alter
gene
expression,
key
determinants
tumor
initiation,
angiogenesis,
metastasis,
therapy
resistance.
Accumulation
genetic
epigenetic
damage,
oxidative
contributes,
eventually
unrestrained
cell
proliferation,
inhibition
differentiation,
evasion
death,
providing
favorable
conditions
for
tumorigenesis.
Colorectal,
breast,
lung,
prostate,
skin
cancers
most
frequent
aging-associated
malignancies,
implicated
their
pathogenesis
behavior.
Our
aim
shed
light
on
molecular
mechanisms
link
stress,
aging,
cancers,
highlighting
impact
both
RONS
antioxidants,
provided
diet
exercise,
immunity,
development
an
antitumor
response.
The
dual
role
ROS
physiological
regulators
signaling
responsible
well
its
use
anti-tumor
therapeutic
purposes,
will
also
be
discussed.
Managing
crucial
promoting
healthy
reducing
risk
tumors.
The
intricate
relationship
between
cancer,
circadian
rhythms,
and
aging
is
increasingly
recognized
as
a
critical
factor
in
understanding
the
mechanisms
underlying
tumorigenesis
cancer
progression.
Aging
well-established
primary
risk
for
while
disruptions
rhythms
are
intricately
associated
with
progression
of
various
tumors.
Moreover,
itself
disrupts
leading
to
physiological
changes
that
may
accelerate
development.
Despite
these
connections,
specific
interplay
processes
their
collective
impact
on
remains
inadequately
explored
literature.
In
this
review,
we
systematically
explore
influence
We
discuss
how
core
genes
tumor
prognosis,
highlighting
shared
hallmarks
such
genomic
instability,
cellular
senescence,
chronic
inflammation.
Furthermore,
examine
aging,
focusing
crosstalk
contributes
tumorigenesis,
proliferation,
apoptosis,
well
metabolism
stability.
By
elucidating
common
pathways
linking
review
provides
new
insights
into
pathophysiology
identifies
potential
therapeutic
strategies.
propose
targeting
regulation
could
pave
way
novel
treatments,
including
chronotherapy
antiaging
interventions,
which
offer
important
benefits
clinical
management
cancer.
Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Aging
is
a
complex
and
universal
process
marked
by
gradual
functional
declines
at
the
cellular
tissue
levels,
often
leading
to
range
of
aging-related
diseases
such
as
diabetes,
cardiovascular
diseases,
cancer.
Delaying
aging
can
help
prevent,
slow
down,
alleviate
severity
these
various
conditions,
enhancing
overall
health
well-being.
Alpha-glucosidase
inhibitors
(AGIs)
are
class
widely
used
antidiabetic
drugs
that
inhibit
alpha-glucosidase
in
small
intestinal
mucosa,
delaying
carbohydrate
absorption
reducing
postprandial
hyperglycemia.
Beyond
their
roles
diabetes
treatment,
AGIs
have
shown
potential
extending
lifespan
effectively
treating
modulating
oxidative
stress,
gut
microbiota,
inflammatory
responses,
nutrient-sensing
pathways.
This
review
summarizes
recent
advancements
application
for
preventing
with
focus
on
mechanisms
processes.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
11
Published: Jan. 8, 2025
Breast
cancer
(BC)
is
the
most
common
in
women
U.S.
and
a
leading
cause
of
cancer-related
deaths.
The
incidence
rises
with
age,
especially
over
70.
Older
patients
often
face
multiple
comorbidities,
complicating
treatment
decisions.
This
study
will
analyze
role
radiotherapy
(RT)
early-stage
triple-negative
breast
(TNBC)
among
elderly
using
SEER
database
to
assess
its
impact
on
survival
outcomes.
aged
70+
T1-2N0-1M0
TNBC
were
selected
from
(2010-2015)
according
specific
inclusion
exclusion
criteria.
Statistical
analyses
involved
chi-square
tests,
propensity
score
matching
(PSM),
Cox
regression
identify
risk
factors.
A
nomogram
was
developed,
Kaplan-Meier
analysis
compared
overall
(OS)
cancer-specific
(BCSS)
across
different
groups.
total
3,024
analyzed.
After
employing
PSM
eliminate
baseline
differences,
indicated
that
breast-conserving
surgery
(BCS)
group
could
benefit
RT
(OS,
HR
=
0.68,
p
<
0.001;
BCSS,
0.64,
0.001).
non-RT
cohort
within
BCS
identified
tumor
grade,
T
stage
as
independent
Subsequently,
developed
stratify
found
significantly
improved
OS
BCSS
intermediate-risk
0.49,
95%
CI
0.34-0.71,
0.40,
0.21-0.77,
0.018)
high-risk
0.67,
0.55-0.81,
0.61,
0.45-0.83,
0.007),
while
showing
no
significant
low-risk
(all
p-values
>
0.05).
improves
after
BCS,
particularly
for
intermediate
individuals,
may
omit
it.
Life,
Journal Year:
2025,
Volume and Issue:
15(2), P. 135 - 135
Published: Jan. 21, 2025
Background:
Cervical
cancer
(CC)
is
the
fourth
most
common
diagnosis
in
women
worldwide.
Infection
with
high-risk
human
papillomavirus
(HPV)
a
critical
but
not
determinative
condition
for
CC
development,
as
several
co-factors
modulate
progression
of
HPV-associated
cervical
lesions.
Interleukin-8
(IL-8)
and
Interleukin-16
(IL-16)
are
chemokine-like
interleukins
involved
pathogenesis
various
cancers.
Singular
studies
Asian
populations
have
suggested
potential
role
IL-8
rs4073
(−251
A>T)
IL-16
rs1131445
(3′UTR
T>C)
carcinogenesis.
Methods:
A
case-control
study
was
conducted
European
cohort
339
women,
including
126
patients
213
controls.
Four
SNPs,
A>T),
rs2227306
(+781
C>T),
rs1126647
(+2767
rs2227543
(+1633
four
polymorphism,
rs4778889
(−295
T>C),
rs11556218
(3441
T>G),
rs4072111
(1300
were
assessed
using
RFLP-PCR
analyzed
under
seven
inheritance
models.
Subgroup
analyses
stratified
by
menopausal
status
(age
threshold
51
years),
disease
stage,
histological
subtype.
Results:
significantly
associated
an
increased
risk
premenopausal
co-dominant
(p
=
0.038),
dominant
0.022),
heterozygote
0.045)
models,
identifying
T
allele
(OR
2.31,
CI95%
1.17–4.56;
p
0.017).
In
aged
over
51,
0.048)
overdominant
0.042)
models
model
0.092).
None
SNPs
entire
cohort.
Specifically,
neither
nor
rs4073,
previously
reported
factors
populations,
this
Conclusions:
These
findings
highlight
age
stage
immunity
susceptibility,
suggest
that
may
function
differently
carcinogenesis
compared
other
cancers,
emphasize
importance
ethnic
background
risk,
warranting
further
research.
BMJ Open,
Journal Year:
2025,
Volume and Issue:
15(1), P. e096522 - e096522
Published: Jan. 1, 2025
Objectives
To
map
the
scope
of
available
evidence
on
relationships
between
multimorbidity
patterns
and
functioning
among
adults
in
low-
middle-income
countries
(LMICs),
describe
methods
used.
Design
Scoping
review
guided
by
a
five-step
methodological
framework
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
extension
reporting
guidelines.
Data
sources
PubMed/MEDLINE,
Scopus,
EBSCOhost
(CINAHL)
Cochrane
databases
were
searched
from
January
1976
to
March
2023,
plus
reference
lists
included
studies.
Eligibility
criteria
selecting
studies
Peer-reviewed
full-text
articles
or
conference
proceedings
any
design,
published
English
Afrikaans,
involving
(>18
years)
with
living
LMICs.
Studies
had
refer
associations
multimorbid
co-occurrence
functioning.
Multimorbidity
was
defined
as
coexistence
≥2
diseases,
including
combination
non-communicable,
infectious
mental
health
conditions.
extraction
synthesis
extracted
independently
two
reviewers
using
piloted
form.
Findings
synthesised
according
approaches,
multimorbidity-pattern
epidemiology,
gaps/limitations
recommendations
future
research.
The
International
Classification
Functioning,
Disability
Health
used
classify
functional
problems.
Results
Nine
(total
sample
size:
62
003)
included,
mainly
upper-middle-income
Asian
countries.
Key
inconsistencies
identified
defining
operationalising
multimorbidity,
conditions
determining
patterns,
statistical
pattern
determination
outcome
measures.
Five
main
domains
emerged:
Cardio-Metabolic
Coronary
Atherosclerotic,
Musculoskeletal,
Respiratory
Digestive/Visceral,
Degenerative,
Mental
Health-Related.
Mobility
limitations,
instrumental
activities
daily
living,
self-care
bowel/bladder
problems
consistently
linked
all
domains.
Conclusions
limited
geographically
skewed
body
literature,
along
inconsistencies,
hampers
comprehensive
understanding
Future
research
should
explore
context-specific
definitions,
employ
transparent
methodologies,
use
standardised
measures
incorporate
diverse
samples
inform
tailored
interventions
policies.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 740 - 740
Published: Feb. 6, 2025
A
pentacyclic
triterpene,
oleanolic
acid
(OA),
has
anti-inflammatory
activity.
The
role
of
in
aging
is
poorly
understood,
and
the
regulatory
mechanism
IGF-1
signaling
still
not
fully
understood.
Thus,
we
hypothesized
that
OA
could
delay
by
regulating
PI3K/AKT/mTOR
pathway
via
insulin-like
growth
factor-1
(IGF-1).
This
study
initially
established
a
replicative
model
bleomycin-induced
human
dermal
fibroblast
(HDF)
mouse
embryonic
(MEF)
cell
lines.
On
this
basis,
inhibitors
or
recombinant
proteins
were
then
combined
with
(at
concentration
20
μM)
treated
for
72
h.
project
plans
to
detect
expression
aging-related
such
as
CDKN2A
(p16)
using
Western
blot
technology,
factors
Interleukin-1
beta
(IL-1β),
Interleukin-6
(IL-6),
Interleukin-8
(IL-8)
Real-Time
Quantitative
Polymerase
Chain
Reaction
(RT-qPCR),
Enzyme-Linked
Immunosorbent
Assay
(ELISA),
other
technologies,
combine
Senescence-Associated
β-Galactosidase
(SA-β-gal)
staining
changes
aging.
IGF-1,
PI3K/AKT/mTOR,
P16,
secretory
(SASP)
IL-1β,
IL-6,
IL-8
was
increased
senescent
cells.
After
treatment
jujuboside,
protein
decreased.
findings
suggested
slowed
down
inhibiting
through
IGF-1.
These
suggest
potential
new
drug
its
mechanisms
anti-aging.
