Advanced Therapeutic Approaches for Metastatic Ovarian Cancer DOI Open Access

Soohyun Choe,

Mir Jeon, Hyunho Yoon

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 788 - 788

Published: Feb. 25, 2025

Ovarian cancer is the fifth leading cause of cancer-related death among women, which one most common gynecological cancers worldwide. Although several cytoreductive surgeries and chemotherapies have been attempted to address ovarian cancer, disease still shows poor prognosis survival rates due prevalent metastasis. Peritoneal metastasis recognized as primary route metastatic progression in cancer. It causes severe symptoms patients, but it generally difficult detect at an early stage. Current anti-cancer therapy insufficient completely treat its high recurrence resistance. Therefore, developing strategies for treating requires a deeper understanding tumor microenvironment (TME) identification effective therapeutic targets through precision oncology. Given that various signaling pathways, including TGF-β, NF-κB, PI3K/AKT/mTOR influence progression, their activity significance can vary depending on type. In these pathways are particularly important, they not only drive also impact TME, contributes potential. The TME plays critical role driving features altered immunologic interactions. Recent advances focused targeting distinct improve treatment outcomes. Deciphering complex interaction between immune populations contributing provides opportunity enhance efficacy. Hereby, this review highlights mechanisms immunological interactions understand improved immunotherapy against

Language: Английский

Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases DOI Creative Commons

Nikhil Raj Selvaraj,

Durga Nandan,

B J Bipin Nair

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 511 - 511

Published: March 29, 2025

Oxidative stress (OS) is an established hallmark of cancer and neurodegenerative disorders (NDDs), which contributes to genomic instability neuronal loss. This review explores the contrasting role OS in stem cells (CSCs) NDDs. Elevated levels reactive oxygen species (ROS) contribute promote tumor initiation progression CSCs, while NDDs such as Alzheimer’s Parkinson’s disease, accelerates death impairs cellular repair mechanisms. Both scenarios involve disruption delicate balance between pro-oxidant antioxidant systems, leads chronic oxidative stress. Notably, CSCs neurons display alterations redox-sensitive signaling pathways, including Nrf2 NF-κB, influence cell survival, proliferation, differentiation. Mitochondrial dynamics further illustrate these differences: enhanced function supports adaptability whereas impairments heighten vulnerability. Understanding common mechanisms OS-induced redox imbalance may provide insights for developing interventions, addressing aging hallmarks, potentially mitigating or preventing both

Language: Английский

Citations

5
PKM2 controls cochlear development through lactate-dependent transcriptional regulation DOI Creative Commons

Mingxuan Wu,

Gaogan Jia,

Yaoqian Liu

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(2)

Published: Jan. 8, 2025

Understanding the role of metabolic processes during inner ear development is essential for identifying targets hair cell (HC) regeneration, as choices play a crucial in proliferation and differentiation. Among processes, growing evidence shows that glucose metabolism closely related to organ development. However, mammalian HC regeneration remains unclear. In this study, we found glycolytic highly active mouse human cochlear prosensory epithelium expansion. Using organoids, revealed activity nonsensory epithelial cells was predominantly dominated by pyruvate kinase M2 (PKM2). Deletion PKM2 induced switch from glycolysis oxidative phosphorylation, impairing organoid formation. Furthermore, conditional loss progenitors hindered sensory morphogenesis, demonstrated knockout mice. Mechanistically, generated catalysis then converted into lactate, which lactylates histone H3, regulating transcription key genes Specifically, accumulated lactate causes H3 lactylation at lysine 9 (H3K9la), upregulating expression Sox family factors through epigenetic modification. Moreover, overexpression supporting (SCs) triggered reprogramming enhanced generation cultured explants. Our findings uncover molecular mechanism formation driven glycolysis-lactate flow suggest unique approaches regeneration.

Language: Английский

Citations

3
Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence DOI Creative Commons
Muhammad Tufail, Canhua Jiang, Ning Li

et al.

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 11, 2025

Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.

Language: Английский

Citations

3
Emerging Role of Extracellular pH in Tumor Microenvironment as a Therapeutic Target for Cancer Immunotherapy DOI Creative Commons
Md. Ataur Rahman,

Mahesh Kumar Yadab,

Meser M. Ali

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1924 - 1924

Published: Nov. 20, 2024

Identifying definitive biomarkers that predict clinical response and resistance to immunotherapy remains a critical challenge. One emerging factor is extracellular acidosis in the tumor microenvironment (TME), which significantly impairs immune cell function contributes failure. However, acidic conditions TME disrupt interaction between cancer cells, driving tumor-infiltrating T cells NK into an inactivated, anergic state. Simultaneously, promotes recruitment activation of immunosuppressive such as myeloid-derived suppressor regulatory (Tregs). Notably, acidity enhances exosome release from Tregs, further amplifying immunosuppression. Tumor thus acts "protective shield," neutralizing anti-tumor responses transforming pro-tumor allies. Therefore, targeting lactate metabolism has emerged promising strategy overcome this barrier, with approaches including buffer agents neutralize pH inhibitors block production or transport, thereby restoring efficacy TME. Recent discoveries have identified genes involved (pHe) regulation, presenting new therapeutic targets. Moreover, ongoing research aims elucidate molecular mechanisms acidification develop treatments modulate levels enhance outcomes. Additionally, future studies are crucial validate safety pHe-targeted therapies patients. Thus, review explores regulation pHe its potential role improving immunotherapy.

Language: Английский

Citations

10
Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges. DOI Creative Commons
Great Iruoghene Edo, Alice Njolke Mafe, Patrick Othuke Akpoghelie

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

Citations

2
Targeting PI3K signaling in Lung Cancer: advances, challenges and therapeutic opportunities DOI Creative Commons

Bitian Zhang,

Ping‐Chung Leung, William C. Cho

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 14, 2025

Abstract Lung cancer remains the leading cause of cancer-related mortality globally, necessitating continual exploration novel therapeutic targets. The phosphoinositide 3-kinase (PI3K) signaling pathway plays a pivotal role in oncogenic processes, including cell growth, survival, metabolism and immune modulation. This comprehensive review delineates distinct roles PI3K subtypes—PI3Kα, PI3Kβ, PI3Kγ PI3Kδ—in lung pathogenesis progression. We evaluate current landscape inhibitors, transitioning from non-selective early-generation compounds to isoform-specific agents, highlighting their clinical efficacy, resistance mechanisms potential combination strategies. Furthermore, intricate interplay between tumor microenvironment is explored, elucidating how modulation can enhance immunotherapeutic responses. Metabolic reprogramming driven by also dissected, revealing vulnerabilities that be therapeutically exploited. Despite promising advancements, challenges such as adverse effects underscore need for personalized medicine approaches development next-generation inhibitors. underscores multifaceted advocates integrated strategies harness its full potential, paving way improved patient outcomes.

Language: Английский

Citations

2
Lysine acetylation and its role in the pathophysiology of acute pancreatitis DOI
Xiaoqian Li, Xiaolu Li, Jinfeng Zhang

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Jan. 8, 2025

Language: Английский

Citations

1
Higher dietary vegetable and fruit intake along with their biomarkers is inversely associated with all-cause mortality among cancer survivors DOI

M L Jiang,

Cai‐Xia Zhang

Nutrition Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Single-Cell RNA Sequencing in Ovarian Cancer: Current Progress and Future Prospects DOI
Zhi Xiong Chong

Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis DOI Creative Commons
Raffaella Chiaramonte,

Giulia Sauro,

Domenica Giannandrea

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 115 - 115

Published: Jan. 20, 2025

The role of mitochondria as the electric engine cells is well established. Over past two decades, accumulating evidence has pointed out that, despite presence a highly active glycolytic pathway (Warburg effect), functional and even upregulated mitochondrial respiration occurs in cancer to meet need high energy biosynthetic demand sustain their anabolic growth. Mitochondria are also primary source intracellular ROS. Cancer maintain moderate levels ROS promote tumorigenesis, metastasis, drug resistance; indeed, once cytotoxicity threshold exceeded, trigger oxidative damage, ultimately leading cell death. Based on this, metabolic functions generation considered attractive targets synthetic natural anticancer compounds. Tocotrienols (TTs), specifically δ- γ-TT isoforms, vitamin E-derived biomolecules widely shown possess striking properties since they regulate several molecular pathways. Herein, we provide for first time an overview reprogramming redox homeostasis perturbation occurring cells, highlighting involvement TTs. This sheds light use these compounds promising preventive or therapeutic approach novel strategies.

Language: Английский

Citations

1