Sanguinarine identified as a natural dual inhibitor of AURKA and CDK2 through network pharmacology and bioinformatics approaches DOI Creative Commons
Xiang Li, Qi You

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 28, 2024

Cervical cancer (CA) continues to be a female malignant tumor with limited therapeutic options, resulting in high mortality rate. Sanguinarine (SANG), naturally occurring alkaloid, has demonstrated notable efficacy preclinical treatment of CA. However, the mechanism through which SANG acts against CA is not fully understood. To address this, utilizing nine drug target prediction databases, we have successfully identified 379 potential targets for SANG. Venn diagram analysis compared 2367 CA-related from GeneCards disease database, 2618 CA-closely related derived multiple datasets GEO WGCNA analysis, and SANG, 35 shared targets. Subsequently, by employing PPI network Cytohubba plugin, Human Protein Atlas, TCGA database data, ROC curve AURKA CDK2 as key combating Single-gene GSEA results suggest that overexpression closely correlated DNA replication, cell cycle progression, various repair pathways Molecular docking molecular simulation dynamics analyses confirmed stable binding both In summary, integrating diverse methodological approaches, this study discovered potentially inhibits features targeting CDK2, thereby regulating pathways. This lays solid foundation further exploring pharmacological role therapy. in-depth vitro vivo experiments are required corroborate our findings.

Language: Английский

Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages DOI
Fuxue Xing, Hongwei Lv, Wei Xiang

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217544 - 217544

Published: Feb. 1, 2025

Language: Английский

Citations

1
Centipeda minima extract exhibits anti-liver cancer effects via the ER stress/HMOX1/Fe2+/ROS pathway DOI

Jinrui Wei,

Xuqi Zhao,

Boquan Wu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156487 - 156487

Published: Feb. 11, 2025

Language: Английский

Citations

1
Kushenol O Regulates GALNT7/NF-κB axis-Mediated M2 Macrophage Polarization and Efferocytosis in Papillary Thyroid Carcinoma DOI
Yutong Li,

Jianhang Miao,

Chizhuai Liu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156373 - 156373

Published: Jan. 14, 2025

Language: Английский

Citations

0
Mechanistic Insights into the Inhibition of Colorectal Cancer by BuShenFang through Adenomatous Polyposis Coli Expression and Wnt/β-catenin Pathway Regulation DOI Creative Commons
Khang Wen Goh, Jie Ji,

Hiu Ching Phang

et al.

Progress In Microbes & Molecular Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 15, 2025

Colorectal cancer (CRC) remains one of the leading causes cancer-related mortality worldwide. Despite advances in chemotherapy and radiotherapy, significant side effects persist, prompting exploration alternative therapies such as traditional Chinese medicine (TCM). BuShenFang (BSF), a TCM formulation, is believed to exhibit anti-CRC effects, although its exact mechanism unclear. This study aims investigate BSF on CRC cells through modulation Wnt/β-catenin pathway. The utilized HCT116 SW620 cell lines, employing vitro experiments including viability assays, colony formation, flow cytometry, Western blot examine influence cellular proliferation, apoptosis, migration, signaling Results demonstrated that significantly inhibited proliferation dose-dependent manner. apoptotic rate was markedly increased 20% group, while invasion capabilities were notably suppressed. Furthermore, results revealed enhanced adenomatous polyposis coli (APC) expression β-catenin, c-Myc, Cyclin D1, key proteins In conclusion, exerts by modulating pathway, suggesting potential complementary therapeutic agent treatment. Future studies should focus vivo models validate these findings.

Language: Английский

Citations

0
Qu-Shi-Jie-Du decoction for prevention of recurrence and metastasis in high-risk stage II/III colon cancer: Study protocol for a double-blind, randomized, placebo-controlled trial DOI Creative Commons
Yadong Chen, Ziyan He,

Wen-jie Zhao

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Background Colorectal cancer is one of the most common and fatal cancers worldwide. Despite therapeutic advancements, patients with stage II III colon often experience recurrences metastases, particularly to liver, leading suboptimal disease-free survival rates decreased long-term survival. Qu-Shi-Jie-Du decoction (QSJDD), a traditional Chinese herbal formula, may prevent recurrence spread by boosting immunity, reducing inflammation, inhibiting tumour growth. Preliminary studies have demonstrated that QSJDD reduces liver metastasis in cancer. However, robust clinical evidence required confirm its efficacy safety. This study aims evaluate safety preventing metastasis, thereby offering potential adjunctive therapy improve patient outcomes. Methods multicentre, double-blind, randomised, placebo-controlled trial includes 336 high-risk or from 10 hospitals across China. After surgery chemotherapy (fluorouracil monotherapy, CAPEOX mFOLFOX6), 168 will be randomised either intervention (QSJDD compound granules) placebo group. The treatment lasts for 6 months, followed 3-year follow-up period assessments conducted every months. primary endpoint rate, whereas secondary endpoints include 1- 2-year relapse rates, overall survival, variations Traditional Medicine Dampness Syndrome Scale. Safety outcomes including adverse events, also monitored. Additionally, blood gut microbiomes analysed investigate effect delaying Discussion determine provide regarding role adjuvant Trial registration Chictr.org.cn Identifier: ChiCTR2300078971. Registered on 22nd December 2023.

Language: Английский

Citations

0
From Traditional to Modern: Nanotechnology-Driven Innovation in Mycotoxin Sensing for Chinese Herbal Medicines DOI
Qi Sun, Daniel Chen,

Xia Ran

et al.

Talanta, Journal Year: 2025, Volume and Issue: 288, P. 127681 - 127681

Published: Feb. 2, 2025

Language: Английский

Citations

0
Rising of natural therapies: Potential and challenges of traditional Chinese medicine in the management of gastrointestinal diseases DOI

Xiao-Tong Tian,

Jiangping Zhan,

Chang Qiao

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(9)

Published: Feb. 18, 2025

In the contemporary medical landscape, burgeoning interest in natural therapies, particularly for managing gastrointestinal disorders, has brought traditional Chinese medicine (TCM) to forefront. This article explains core principles and clinical applications of TCM treating these conditions, furthering discourse through an examination integrated strategies, as demonstrated study by Zhou et al. While shown promising outcomes, it encounters significant hurdles standardization, mechanistic research, validation. Future investigations should aim solidify scientific underpinnings expand its use disease management, striving a seamless fusion practices.

Language: Английский

Citations

0
Astragali Radix-Curcumae Rhizoma normalizes tumor blood vessels by HIF-1α to anti-tumor metastasis in colon cancer DOI Creative Commons

Yan Liang,

Tingting Su,

Shijiao Zhu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156562 - 156562

Published: Feb. 25, 2025

Language: Английский

Citations

0
Network pharmacology combined with transcriptomics reveals that Ganoderma lucidum spore and Sanghuangporus vaninii compound extract exerts anti-colorectal cancer effects via CYP24A1-mediated VDR pathway and TERT-mediated Wnt signaling pathway DOI
Jian Zhong Huo, Kun Nie,

Tianfeng Yang

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119820 - 119820

Published: April 1, 2025

Language: Английский

Citations

0
The Role of Complementary and Alternative Therapies in the Regulation of Gut Microbiota DOI
Mi Liu,

Sihui Cao,

Haihua Xie

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

The gut microbiota constitutes a complex ecosystem, and its composition function are intricately linked to human health. Dysbiosis of the is closely associated with onset progression various diseases, including gastrointestinal, immune system, metabolic, neurological disorders. Consequently, modulating reestablish balance has emerged as crucial strategy for prevention treatment these diseases. This chapter will delve into roles complementary alternative therapies, such acupuncture, massage, Chinese herbal medicine, dietary therapy, exercise, psychological interventions, in microbiota. It underscore significant role therapies beneficial complement modern medicine context holistic pathology. These not only modulate but also enhance physiological functions body improve body’s self-healing ability through regulation. offer unique advantages clinical applications, fewer side effects, simple operations, easy integration daily life. By systematically analyzing mechanisms action application prospects this aims provide readers comprehensive in-depth perspective understand value modulation references future research applications.

Language: Английский

Citations

0