Desulfovibrio in the Gut: The Enemy within?

Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1772 - 1772

Published: July 7, 2023

Desulfovibrio (DSV) are sulfate-reducing bacteria (SRB) that ubiquitously present in the environment and as resident commensal within human gastrointestinal tract. Though they minor residents of healthy gut, DSV opportunistic pathobionts may overgrow setting various intestinal extra-intestinal diseases. An increasing number studies have demonstrated a positive correlation between overgrowth (bloom) While relationship bloom disease pathology has not been clearly established, mounting evidence suggests causal role for these development. As most predominant genera SRB this review summarizes current knowledge regarding variety In study, we also discuss mechanisms by which contribute to pathology.

Language: Английский

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Effects of Ganjianglingzhu Decoction on Lean Non-Alcoholic Fatty Liver Disease in Mice Based on Untargeted Metabolomics

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 502 - 502

Published: April 15, 2024

Non-alcoholic fatty liver disease (NAFLD) is usually associated with obesity. However, it crucial to recognize that NAFLD can also occur in lean individuals, which frequently overlooked. Without an approved pharmacological therapy for NAFLD, we aimed investigate whether the Ganjianglingzhu (GJLZ) decoction, a representative traditional Chinese medicine (TCM), protects against and explore potential mechanism underlying these protective effects. The mouse model of was established methionine-choline-deficient (MCD) diet male C57BL/6 mice be compared control group fed methionine-choline-sufficient (MCS) diet. After four weeks, physiological saline, low dose GJLZ decoction (GL), or high (GH) administered daily by gavage MCD group; MCS given saline gavage. Untargeted metabolomics techniques were used further effects on NAFLD. Different doses able ameliorate steatosis, inflammation, fibrosis, oxidative stress liver; GL performed better effect In addition, 78 candidate differential metabolites screened identified. Combined metabolite pathway enrichment analysis, capable regulating glucose lipid glycerophospholipid metabolism altering levels sn-3-O-(geranylgeranyl)glycerol 1-phosphate lysoPC(P-18:0/0:0). may protect development metabolism, inhibiting lysoPC(P-18:0/0:0) metabolism.

Language: Английский

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Fructus gardeniae ameliorates anxiety-like behaviors induced by sleep deprivation via regulating hippocampal metabolomics and gut microbiota

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: June 12, 2023

Fructus gardeniae (FG) is a traditional Chinese medicine and health food for thousands of years application throughout history still widely used in clinical medicine. FG has beneficial impact on anxiety, depression, insomnia, psychiatric disorders; however, its mechanism action requires further investigation. This study aimed to investigate the effects mechanisms sleep deprivation (SD)-induced anxiety-like behavior rats. A model SD-induced rats was established by intraperitoneal injection p-chlorophenylalanine (PCPA). accompanied neuroinflammation metabolic abnormalities hippocampus disturbance intestinal microbiota. However reduced decreased levels pro-inflammatory cytokines including TNF-α IL-1β were observed after 7 days intervention. In addition, metabolomic analysis demonstrated that able modulate phosphatidylserine 18, Phosphatidylinositol sn-glycero-3-phosphocholine, deoxyguanylic acid, xylose, betaine other metabolites hippocampus. The main pathways hippocampal intervention involve carbon metabolism, glycolysis/gluconeogenesis, pentose phosphate, glycerophospholipid metabolism. 16S rRNA sequencing illustrated ameliorated dysbiosis gut microbiota anxious rats, mainly increased abundance Muribaculaceae Lactobacillus, Lachnospiraceae_NK4A136_group. correlation there close relationship between conclusion, improved anxiety inhibited sleep-deprived may be related regulation microflora composition.

Language: Английский

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Analysis of 16s rRNA Gene Sequencing in Feces: The Impact of Bariatric Surgery on the Gut Microbiota in Patients with Obesity

Obesity Surgery, Journal Year: 2024, Volume and Issue: 34(4), P. 1185 - 1195

Published: Feb. 22, 2024

Language: Английский

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Role of microbiota-gut-brain axis in natural aging-related alterations in behavior

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: April 18, 2024

Aging is a complex, time-dependent biological process that involves decline of overall function. Over the past decade, field intestinal microbiota associated with aging has received considerable attention. However, there limited information surrounding microbiota-gut-brain axis (MGBA) to further reveal mechanism aging.

Language: Английский

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Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10871 - 10871

Published: Oct. 10, 2024

Probiotics, known for regulating gut microbiota, may aid those with overweight or obesity, but their mechanisms require more research. This study involved 75 obese young adults, randomly assigned to either a

Language: Английский

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Multi‐omics reveals different signatures of obesity‐prone and obesity‐resistant mice

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract Obesity‐prone (OP) and obesity‐resistant (OR) individuals demonstrate significant metabolic differences, potentially influenced by variations in the gut microbiome. However, influence of host–microbiota interactions on obesity susceptibility remains unknown. We performed an integrative multi‐omics approach to explore microbial, metabolic, genetic differences high‐fat diet (HFD)‐fed OP OR mice, with additional analyses microbiota humans. In dynamic was characterized a stable presence Longibaculum , while Kineothrix predominated mice. termed both as keystone bacteria. Beyond these, eight dominant bacterial genera were significantly associated bile acid metabolites amino acids. Three these also identified humans showed positive correlations genes that may support intestinal barrier function. 22 specific profiles potential biomarkers for susceptibility, along increased levels ten non‐12‐OH acids fecal vivo, mouse experiments demonstrated ursodeoxycholic hyodeoxycholic could reduce HFD‐induced obesity. Additionally, colon mice displayed higher inflammatory cells. These findings suggest contribute phenotypic between OR. Our study offers insights into crucial markers obesity, providing valuable resource advancing understanding obesity‐prone phenotypes.

Language: Английский

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Hypoglycemic effect of dietary fibers from Moringa oleifera leaves: In vitro and in vivo studies

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116196 - 116196

Published: March 1, 2025

Language: Английский

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Multi-trajectories of BMI, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study

mSystems, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

ABSTRACT Evidence is insufficient to establish a longitudinal association between combined trajectories of body mass index (BMI) and waist circumference (WC) dyslipidemia. This study investigated the associations multi-trajectories BMI WC over 24 years subsequent risk dyslipidemia in large cohort 10,678 Chinese adults from China Health Nutrition Survey. Utilizing group-based trajectory model, we identified four distinct trajectories: normal, normal-increasing, overweight-increasing, obesity-increasing. Our results indicated that ascending are significantly associated with increased odds dyslipidemia, particularly males, ratios (OR) 2.10, 2.69, 3.56 for obesity-increasing groups, respectively. Among females, normal-increasing group exhibited significant (OR: 1.54). Furthermore, explored gut microbiota these trajectories, identifying 3, 8, 4 bacterial genera linked increasing alongside two females trajectory. We total 23, 25, 10 differential metabolites genera, except Group 2 males. The inclusion relevant microbiome metabolite data improved model’s predictive capacity ROC values 0.655 0.875. findings underscore critical implications continuous weight gain on metabolic health suggest may play pivotal role understanding associations. IMPORTANCE Emerging evidence suggests close connection both human obesity suggesting an important obesity-dyslipidemia relationship. In this study, observed several characteristic including Clostridium_sensu_stricto_1 , Turicibacter CHKCI002 among males Parabacteroides [Eubacterium]_brachy_group which were negatively high-risk trajectories. They also related free fatty acids (FFAs) oxidized lipid metabolites. These shared unique microbial signatures higher could provide omics mechanism pathway long-term trend leading

Language: Английский

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Uncovering the heterogeneity of the gut microbial taxa associated with the contents of different fatty acids in muscle with cecum luminal content and fecal samples from two pig populations

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Fatty acids in pork are involved cellular physiological functions and related to meat nutrition, tenderness, flavor. Increasing evidences have suggested that short-chain fatty produced by the gut microbiota may affect host metabolism energy utilization. However, association between long-chain (LCFAs) has been largely unknown. In this study, microbial compositions of 243 cecum content samples from Erhualian pigs 235 fecal Bamaxiang were determined high throughput 16S rRNA gene sequencing. The contents 12 LCFAs longissimus dorsi (LD) muscle also for all experimental both pig populations. We systematically evaluated contribution variations acid α -diversity microbiota, co-abundance groups (CAGs) Amplicon Sequence Variants (ASVs), acid-associated bacterial taxa. identified hundred ASVs > 40 taxa significantly associated with two Different numbers specific detected luminal samples, suggesting heterogeneity LCFA-associated locations. uncovered some interesting associations contents. strongest was observed ASV annotated Akkermansia n-6/n-3 polyunsaturated ratio ( p = 6.45E-04, Z −9.65). could explain 1.47–4.62% variation twelve acids. functional prediction analysis KEGG pathways metabolisms carbohydrate lipids, fat digestion absorption positively adipocytokine signaling pathway thermogenesis negatively results study provided basic knowledge improving regulating microbiome.

Language: Английский

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