Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 27, 2025

Language: Английский

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Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 269 - 269

Published: Jan. 16, 2024

Nutrition is one of the most influential environmental factors in both taxonomical shifts gut microbiota as well development type 2 diabetes mellitus (T2DM). Emerging evidence has shown that effects nutrition on these parameters not mutually exclusive and changes related metabolites such short-chain fatty acids (SCFAs) branched-chain amino (BCAAs) may influence systemic inflammation signaling pathways contribute to pathophysiological processes associated with T2DM. With this background, our review highlights macronutrients, carbohydrates, proteins, lipids, micronutrients, vitamins, minerals, T2DM, specifically through their alterations they produce. Additionally, we describe influences common food groups, which incorporate varying combinations macronutrients metabolic context mellitus. Overall, first line modifiable therapies management T2DM a better understanding mechanisms by its pathophysiology provides opportunities for optimizing dietary interventions.

Language: Английский

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Effects of data transformation and model selection on feature importance in microbiome classification data

Microbiome, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 4, 2025

Abstract Background Accurate classification of host phenotypes from microbiome data is crucial for advancing microbiome-based therapies, with machine learning offering effective solutions. However, the complexity gut microbiome, sparsity, compositionality, and population-specificity present significant challenges. Microbiome transformations can alleviate some aforementioned challenges, but their usage in tasks has largely been unexplored. Results Our analysis over 8500 samples 24 shotgun metagenomic datasets showed that it possible to classify healthy diseased individuals using minimal dependence on choice algorithm or transformation. Presence-absence performed comparably abundance-based transformations, only a small subset predictors necessary accurate classification. while different resulted comparable performance, most important features varied significantly, which highlights need reevaluate learning–based biomarker detection. Conclusions significantly influence feature selection have limited effect accuracy. findings suggest robust across variation necessitates caution when identification. This research provides valuable insights applying identifies directions future work.

Language: Английский

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In vivo absorption, in vitro simulated digestion, and fecal fermentation properties of Imperata cylindrica polysaccharides and their effects on gut microbiota

Food Chemistry, Journal Year: 2024, Volume and Issue: 461, P. 140773 - 140773

Published: Aug. 5, 2024

Language: Английский

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All-trans retinoic acid alleviates collagen-induced arthritis and promotes intestinal homeostasis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 20, 2024

Language: Английский

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Digestive characteristics of Gastrodia elata Blume polysaccharide and related impacts on human gut microbiota in vitro

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 118064 - 118064

Published: March 21, 2024

Language: Английский

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Polysaccharides from Eucommia ulmoides Oliv. Leaves Alleviate Acute Alcoholic Liver Injury by Modulating the Microbiota–Gut–Liver Axis in Mice

Foods, Journal Year: 2024, Volume and Issue: 13(7), P. 1089 - 1089

Published: April 2, 2024

The interplay among gut microbiota, intestines, and liver is crucial in preventing acute alcoholic injury. In this study, the hepatoprotective potential of polysaccharides from Eucommia ulmoides Oliv. leaves (EULP) on injury Kunming male mice was investigated. structural features suggested that EULP appeared as a heterogeneous mixture with molecular weight 186132 Da. A 14-day pretreatment ameliorated alcoholic-induced hepatic inflam mation (TNF-α, IL-6, IL-10), oxidative stress (GSH, SOD, T-AOC), damage (ALT AST) via enhancing intestinal barrier (Occludin, Claudin 1, ZO-1) modulating microbiome, which subsequently inhibiting endotoxemia balancing homeostasis gut–liver axis. restored composition flora an increase relative abundance Lactobacillaceae decrease Lachnospiraceae Verrucomicrobiaceae. Notably, prolonged (14 days) but no single gavage achieved excellent hepatoprotection. These findings endorsed functional food for mitigating alcoholic-induce d damage, attributed to its anti-inflammatory, antioxidant, prebiotic properties facilitated by microbiota–gut–liver

Language: Английский

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Aberrant bowel movement frequencies coincide with increased microbe-derived blood metabolites associated with reduced organ function

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(7), P. 101646 - 101646

Published: July 1, 2024

Bowel movement frequency (BMF) directly impacts the gut microbiota and is linked to diseases like chronic kidney disease or dementia. In particular, prior work has shown that constipation associated with an ecosystem-wide switch from fiber fermentation short-chain fatty acid production more detrimental protein toxin production. Here, we analyze multi-omic data generally healthy adults see how BMF affects their molecular phenotypes, in a pre-disease context. Results show differential abundances of microbial genera, blood metabolites, variation lifestyle factors across categories. These differences relate inflammation, heart health, liver function, function. Causal mediation analysis indicates association between lower reduced function partially mediated by microbially derived 3-indoxyl sulfate (3-IS). This result, context, suggests accumulation microbiota-derived toxins abnormal precede organ damage may be drivers chronic, aging-related diseases.

Language: Английский

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S/O/W Emulsion with CAPE Ameliorates DSS-Induced Colitis by Regulating NF-κB Pathway, Gut Microbiota and Fecal Metabolome in C57BL/6 Mice

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1145 - 1145

Published: April 12, 2024

Inflammatory bowel disease (IBD) has attracted much attention worldwide due to its prevalence. In this study, the effect of a solid-in-oil-in-water (S/O/W) emulsion with Caffeic acid phenethyl ester (CAPE, polyphenolic active ingredient in propolis) on dextran sulfate sodium (DSS)-induced colitis C57BL/6 mice was evaluated. The results showed that CAPE-emulsion could significantly alleviate DSS-induced through effects colon length, reduction activity index (DAI), and histopathology. ELISA Western blot analysis can down-regulate excessive inflammatory cytokines tissue inhibit expression p65 NF-κB pathway. Furthermore, promoted short-chain fatty acids production mice. High-throughput sequencing revealed regulates imbalance gut microbiota by enhancing diversity, restoring abundance beneficial bacteria (such as Odoribacter), suppressing harmful Afipia, Sphingomonas). fecal metabolome restored metabolic disorder affecting pathways related inflammation cholesterol metabolism. These research provide scientific basis for use CPAE-emulsions development functional foods treating IBD.

Language: Английский

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Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and the release of inflammatory factors, thereby influencing Aβ pathology

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: March 27, 2024

Alzheimer's disease (AD) is an age-related neurodegenerative disorder with no effective interventions for curing or modifying its progression. However, emerging research suggests that vitamin A in the diet may play a role both prevention and treatment of AD, although exact mechanisms are not fully understood. This study aims to investigate dietary modifies gut microbiota intestinal tissue transcriptome, impacting permeability release inflammatory factors, thereby influencing Aβ pathology shedding light on potential as intervention AD treatment. The APP/PS1-AD mouse model was employed divided into three groups: A-deficient (VAD), normal (VAN), A-supplemented (VAS) 12-week study. Neurobehavioral functions were assessed using Morris Water Maze Test (MWM). Enzyme-linked immunosorbent assay (ELISA) used quantify levels Diamine Oxidase (DAO), D-lactate, IL-6, IL-1β, TNF-a cytokines. Serum analyzed via LC-MS/MS analysis. Immunohistochemical analysis morphometry performed evaluate deposition brain tissue. APP/PS1 mice 16S rRNA sequencing Additionally, transcriptomic conducted from mice. No significant changes food intake body weight observed among groups. VAD VAS groups showed reduced compared VAN group at various time points. In terms cognitive function, better Test, indicating superior learning memory abilities. exhibited impaired performance, performing relatively than group. concentrations differed significantly groups, having highest concentration. higher Microbial revealed had microbial diversity group, specific taxa characterizing each characterized by such Actinohacteriota Desulfovibrionaceae, while Parabacteroides Tannerellaceae. similarities like Desulfobacterota Desulfovibrionaceae being present. vs. VAS, VAN, comparisons identified 571, 313, 243 differentially expressed genes, respectively, which associated cellular metabolic processes, pathway enrichment pathways related chemical carcinogenesis, drug metabolism, glutathione immune-related processes. diamine oxidase, cytokines (TNF-a, IL-6) Dietary supplementation modulates microbiota, permeability, protein formation, offering insights pathogenesis therapeutic avenues further exploration. highlights intricate interplay between diet, emphasizing importance managing AD-related pathologies.

Language: Английский

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