Metabolic-associated fatty liver disease and pregnancy complications: new challenges and clinical perspectives DOI Creative Commons
Yang Zhang, Yifan Bu, Rui Zhao

et al.

Therapeutic Advances in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

The term metabolic-associated fatty liver disease (MAFLD), with a global prevalence estimated at 38.77%, has gradually replaced the traditional concept of non-alcoholic (NAFLD). Compared to general population, incidence MAFLD is notably higher among pregnant women, posing potential risks both maternal and neonatal health. This review summarizes latest research on MAFLD, focusing its association pregnancy complications. Additionally, it provides comparative analysis previous studies NAFLD, presenting comprehensive perspective for clinical management. Findings suggest that women face risk gestational hypertension cesarean delivery compared those while diabetes mellitus remains similar between two conditions. associated an increased likelihood delivering large-for-gestational-age infants heightened preterm birth low weight. Current treatment strategies focus lifestyle modifications, such as dietary adjustments physical activity. However, there urgent need development safe effective pharmacological treatments, particularly tailored toward women. Future should delve deeper into causal relationships complications explore optimal therapeutic approaches improve outcomes mothers their infants.

Language: Английский

Development and validation of machine learning models for MASLD: based on multiple potential screening indicators DOI Creative Commons
Hao Chen, Jingjing Zhang,

Xueqin Chen

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 21, 2025

Background Multifaceted factors play a crucial role in the prevention and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to utilize multifaceted indicators construct MASLD risk prediction machine learning models explore core within these models. Methods were constructed based on seven algorithms using all variables, insulin-related demographic characteristics other indicators, respectively. Subsequently, partial dependence plot(PDP) method SHapley Additive exPlanations (SHAP) utilized explain roles important variables model filter out optimal for constructing model. Results Ranking feature importance Random Forest (RF) eXtreme Gradient Boosting (XGBoost) found that both homeostasis assessment insulin resistance (HOMA-IR) triglyceride glucose-waist circumference (TyG-WC) first second most variables. The with top 10 was superior previous PDP SHAP methods further screen best (including HOMA-IR, TyG-WC, age, aspartate aminotransferase (AST), ethnicity) model, mean area under curve value 0.960. Conclusions HOMA-IR TyG-WC are predicting risk. Ultimately, our AST, ethnicity.

Language: Английский

Citations

2
Association between triglyceride glucose index-related indices with gallstone disease among US adults DOI Creative Commons

Chang Fu,

Xiaocong Li, Yongxin Wang

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 27, 2024

Abstract Background Triglyceride glucose (TyG) index combined with obesity-related indicators [triglyceride glucose-body mass (TyG-BMI), triglyceride glucose-waist to height ratio (TyG-WHtR), circumference (TyG-WC)], represents emerging methodologies for assessing insulin resistance. The objective of this investigation was explore the correlation between TyG-related indices and gallstone disease. Methods study included 3740 adults from 2017–2020 period National Health Nutrition Examination Survey. TyG-BMI, TyG-WC, TyG-WHtR were integrated as both continuous categorical variables within multivariate logistic model, respectively evaluate connection various Additionally, restriction cubic splines subgroup analysis employed deepen our understanding relationship. Results When analyzed variables, positive correlations observed OR(95%CI) 1.063(1.045,1.082) TyG-BMI (per 10-unit), 1.026(1.018,1.034) TyG-WC 10-unit) 1.483(1.314,1.676) 1-unit), respectively. categorized into quartiles, these three still show statistically significant associations Descending in order, diagnostic capability disease is demonstrated follows: (AUC = 0.667), 0.647), 0.640). Conclusion There significantly indices, including TyG-WHtR, Of most favorable performance identifying risk

Language: Английский

Citations

13
Lipid-based insulin-resistance markers predict cardiovascular events in metabolic dysfunction associated steatotic liver disease DOI Creative Commons
Alessandra Colantoni, Tommaso Bucci, Nicholas Cocomello

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 20, 2024

Insulin resistance (IR) is the cornerstone of Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), pathophysiologically being key link between MASLD, metabolic disorders, and cardiovascular (CV) diseases. There are no prospective studies comparing predictive values different markers insulin in identifying presence MASLD associated risk events (CVEs).

Language: Английский

Citations

12
Correlation analysis of the triglyceride–glucose index and related parameters in metabolic dysfunction-associated fatty liver disease DOI Creative Commons
Xin Yang,

Huiting Rao,

Yi Yuan

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

Citations

1
The curvilinear relationship between hepatic steatosis index and depression: Findings from the NHANES DOI Creative Commons
Chunqi Jiang, Wei Wang, Jun Wang

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 375, P. 35 - 43

Published: Jan. 19, 2025

Language: Английский

Citations

1
Correlation between liver fibrosis in non-alcoholic fatty liver disease and insulin resistance indicators: a cross-sectional study from NHANES 2017–2020 DOI Creative Commons
Bo Yang, Min Gong, Xiaojie Zhu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

Introduction Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic worldwide, with fibrosis (LF) being crucial pathological feature in the progression NAFLD. Insulin resistance (IR) believed to play an important role pathogenesis NAFLD and development LF. This study aims explore relationship between various IR indicators LF patients Methods utilized data from National Health Nutrition Examination Survey 2017-2020 cycles. Liver steatosis were assessed using ultrasound transient elastography. To assess association multiple LF, methodology included univariate multivariate logistic regression, as well restricted cubic spline (RCS) analysis. Subsequently, we used regression develop validate predictive model for evaluated model’s performance area under curve (AUC) calibration curve. Results A total 904 final Among these patients, 153 (16.92%) had Compared non-LF significantly higher body mass index (BMI), waist circumference (WC), alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT), HbA1c, fasting blood glucose (FBG) levels (all p < 0.05). Analysis showed that TyG, TyG-WHtR, TyG-BMI, TyG-WC, TyG-GGT, METS-IR, HOMA-IR After adjusting covariates, TyG-WHtR remained independent risk factor (OR=2.69; 95% CI: 2.08-3.47), indicating strong correlation The developed nomogram, incorporating AST, diabetes, AUC 0.809 (95% 0.771-0.847), good patients. Conclusions confirms significant nomogram provides practical tool early assessment. These findings underscore clinical value indices into routine practice identify high-risk enabling timely interventions prevent improve outcomes.

Language: Английский

Citations

1
Relationship between TyG-related index and hearing loss in people over 45 s in China DOI Creative Commons
Chao Wang,

Mengdi Shi,

Liangzhen Xie

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 5, 2025

Background Triglycerides and fasting glycemic index are biomarkers used to assess the risk of insulin resistance metabolic syndrome. It its derivatives such as TyG-BMI currently able reflect degree closely related a variety diseases. The relationship between hearing loss remains underexplored, particularly in context aging public health. This study investigates association TyG index, BMI with loss, focus on their potential implications for population. Methods Data from China Health Retirement Longitudinal Study (CHARLS) database were analyzed using R software. We applied multi-factor logistic regression, linear restricted cubic splines, subgroup analyses impact across different age groups. Results was not significantly associated loss. However, both exhibited positive correlation among older individuals. results suggest that population ages, higher indices may increase impairment. Conclusion While does show significant link an increased especially adults. These findings highlight importance considering aging-related factors health initiatives aimed at preventing Further research is needed elucidate mechanisms underlying these associations develop age-inclusive strategies addressing impairment

Language: Английский

Citations

0
Associations between indicators of lipid and glucose metabolism and hypothyroidism DOI Creative Commons
Xinyi Huang,

Huaiping Cheng,

Shuting Wang

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Associations of triglyceride glucose-body mass index and the combination of sedentary behavior and physical activity with risks of all-cause mortality and myocardial infarction: a cohort study from the UK biobank DOI Creative Commons
Ying Zhu, Tianci Yao, Tian Li

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 1, 2025

Triglyceride glucose-body mass (TyG-BMI) index, sedentary behavior (SB) and physical activity (PA) are independently associated with all-cause mortality myocardial infarction (MI). However, it remains unclear whether TyG-BMI index the combination of SB PA exhibit joint effects on MI. Among 502 356 participants from UK Biobank, 297 761 eligible were selected. The Cox proportional hazards model restricted cubic spline regression used to assess associations To conduct stratified analysis, classified into four groups by (<6 h/d ≥ 6 h/d) moderate vigorous (MVPA) (<150 min/wk 150 min/wk). Additionally, multiplicative interaction was assessed between & MVPA. Furthermore, estimate their associations, conjointly twelve new (tertiles) MVPA (four groups). During a median follow-up 13.8 13.6 years, 21 335 deaths 9 116 MI observed, respectively. dose-response relationship U-shaped cut-off point at 225.09, whereas positive nonlinear 266.87. A synergistic effect observed tertile 1 <150 (P for < 0.001). When combined either <6 or not, 2 showed no significant association risk, HRs(95%CIs) 0.98 (0.93-1.03) 1.00 (0.94-1.07) SB. one two healthy behaviors present (i.e., MVPA, SB), its 1.07(0.95-1.20) 1.09(0.94-1.25), jointly risks Our findings highlight importance improving insulin resistance reduce particularly in individuals long-term insufficient PA, who more susceptible adverse index. In individuals, meeting guidelines (≥ MVPA) effectively mitigated

Language: Английский

Citations

0
The association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease and liver fibrosis in US adults DOI Creative Commons
Wanqian Liu, Xiaozhong Li, Chen Ling

et al.

BMC Endocrine Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 11, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic disease, also considered a metabolic syndrome, and associated with poor prognosis. eGDR (estimated glucose disposal rate) new biomarker to assessment insulin resistance (IR). The association between MASLD fibrosis currently unclear. aim of this cross-sectional study appraise fibrosis. This have enrolled 3,100 participants from 2017–2018 National Health Nutrition Examination Surveys (NHANES). Binary logistic regression analysis was used assess Receiver operating characteristic (ROC) applied estimate ability identify MASLD. mean age subjects 54.59 (17.29) years, 49.26% were female. prevalence 62.19% 11.15%, respectively. In fully adjusted models, there negative associations controlled attenuation parameter (CAP) stiffness measurement (LSM), βs -15.18 − 0.74 (all p < 0.01), There fibrosis, odds ratios (ORs) 95% confidence intervals 0.53 (95% CI: 0.48–0.74) 0.40 0.28–0.57) 0.01). area under curve (AUC) for identifying 0.75, findings suggest significant as well may serve

Language: Английский

Citations

0