Therapeutic Advances in Endocrinology and Metabolism,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
The
term
metabolic-associated
fatty
liver
disease
(MAFLD),
with
a
global
prevalence
estimated
at
38.77%,
has
gradually
replaced
the
traditional
concept
of
non-alcoholic
(NAFLD).
Compared
to
general
population,
incidence
MAFLD
is
notably
higher
among
pregnant
women,
posing
potential
risks
both
maternal
and
neonatal
health.
This
review
summarizes
latest
research
on
MAFLD,
focusing
its
association
pregnancy
complications.
Additionally,
it
provides
comparative
analysis
previous
studies
NAFLD,
presenting
comprehensive
perspective
for
clinical
management.
Findings
suggest
that
women
face
risk
gestational
hypertension
cesarean
delivery
compared
those
while
diabetes
mellitus
remains
similar
between
two
conditions.
associated
an
increased
likelihood
delivering
large-for-gestational-age
infants
heightened
preterm
birth
low
weight.
Current
treatment
strategies
focus
lifestyle
modifications,
such
as
dietary
adjustments
physical
activity.
However,
there
urgent
need
development
safe
effective
pharmacological
treatments,
particularly
tailored
toward
women.
Future
should
delve
deeper
into
causal
relationships
complications
explore
optimal
therapeutic
approaches
improve
outcomes
mothers
their
infants.
Canadian Journal of Gastroenterology and Hepatology,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Background:
Triglyceride
glucose
(TyG)
and
its
related
index
(TyG-body
mass
index,
TyG-BMI)
are
recognized
as
markers
for
nonalcoholic
fatty
liver
disease
(NAFLD),
but
their
associations
with
metabolic
dysfunction-associated
steatotic
(MASLD)
significant
fibrosis
(SLF)
risk
less
studied.
Therefore,
this
study
explores
the
effectiveness
of
these
indices
in
assessing
MASLD
SLF
U.S.
population.
Methods:
Utilizing
data
from
National
Health
Nutrition
Examination
Survey
(NHANES),
a
cross-sectional
involving
5520
participants
general
population
was
performed.
This
research
measured
demographic,
anthropometric,
biochemical,
comorbid,
lifestyle
characteristics,
all
which
considered
factors
MASLD/SLF.
Results:
Upon
controlling
confounding
variables,
only
TyG-BMI
found
to
have
consistent
positive
association
SLF.
Specifically,
each
standard
deviation
increase,
odds
ratio
(OR)
95%
confidence
interval
(CI)
were
4.44
(3.64-9.26,
p
trend
<
0.001)
2.48
(2.15-2.87,
Significant
interactions
identified
among
age,
sex,
associated
TyG-BMI.
The
also
had
threshold
effect
on
at
cutoff
point
180.71.
Furthermore,
area
under
receiver
operating
characteristic
curve
(AUC)
revealed
that
better
predicted
(AUC
0.820,
CI
0.810-0.831;
AUC
0.729,
0.703-0.756,
respectively).
In
addition,
integrated
discrimination
improvement
(IDI),
decision
analysis
(DCA),
net
reclassification
(NRI)
demonstrated
satisfactory
predictive
ability
Conclusions:
Within
large
dataset,
independently
both
score
cohort.
Its
efficacy
consistently
surpassed
TyG
other
noninvasive
models,
indicating
has
potential
early
identification
risk.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 16, 2025
Abstract
Objective
This
study
examines
the
association
between
hepatic
steatosis
(HS)
and
liver
fibrosis
risk
in
individuals
with
similar
metabolic
disorders
but
differing
dysfunction
indicators.
Methods
A
cross-sectional
was
conducted
at
First
Hospital
of
Lanzhou
University
from
January
to
November
2024,
involving
undergoing
physical
examinations.
Laboratory
tests,
vascular
abdominal
ultrasound
examinations,
clinical
data
were
collected
assess
characteristics.
Logistic
regression
models
used
explore
relationship
dysfunction,
HS,
degree.
Results
total
4,006
patients
included,
1,164
(29.06%)
females
2,157
(53.84%)
having
HS.
Univariate
logistic
identified
HS
as
a
factor
for
early
(odds
ratio
[OR]:
1.67,
95%
CI:
1.47–1.89,
P
<
0.001).
However,
after
adjusting
indicators,
correlation
weakened
or
reversed.
Multivariate
analysis,
accounting
confounders,
found
be
protective
(OR:
0.57,
0.45–0.71,
0.001),
while
body
roundness
index
1.62,
1.32–
2.00,
0.001)
hyperglycemia
13.28,
10.76–16.39,
factors.
Propensity
score
matching
revealed
880
matched
pairs
patients,
showing
that
among
those
atherosclerotic
plaques
0.58,
0.42–0.79,
0.63,
0.43–0.93,
=
0.02),
associated
reduced
fibrosis.
The
non-HS
group
had
strongest
ability
detect
(AUC:
0.52–0.61,
0.003).
Conclusion
Metabolic
is
positively
correlated
particularly
plaque
formation,
population
higher
Financial
support
National
Natural
Science
Foundation
China
(82360132),
Major
Technology
Innovation
Project
Gansu
Provincial
Health
Industry
(GSWSZD2024-11),
Joint
Scientific
Research
Fund
Province
(23JRRA1489,
24JRRA911),
Key
Talent
(GanZuTongZi
[2024]
No.4),
Open
Extreme
Environment
Microbiology
(EEMRE202401),
Development
Program
(22YF7FA085),
Traditional
Chinese
Medicine
(GZKZ-2022-7),
Bureau
(2023-2-76),
Medical
Education
Projects
(lzuyxcx-2022-131;
lzuyxcx-2022-213;
lzuyxcx-2022-147).
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: June 14, 2024
MAFLD
has
become
a
major
global
health
problem
and
is
the
leading
cause
of
liver
disease
worldwide.
The
progresses
from
simple
fatty
to
gradual
fibrosis,
which
cirrhosis
even
hepatocellular
cancer.
However,
methods
currently
used
for
diagnosis
are
invasive
do
not
facilitate
clinical
assessment
condition.
As
result,
research
on
markers
increasing.
In
addition,
there
no
medications
treatment
MAFLD,
lifestyle
interventions
remain
effective
in
prevention
MAFLD.
this
review,
we
attempt
make
summary
emerging
diagnostic
indicators
provide
new
insights
into
BMC Endocrine Disorders,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Dec. 4, 2024
The
triglyceride-glucose
(TyG)
index
and
related
parameters,
as
well
the
Homeostatic
Model
Assessment
for
Insulin
Resistance
(HOMA-IR),
have
been
developed
insulin
resistance
markers
to
identify
individuals
at
risk
non-alcoholic
fatty
liver
disease
(NAFLD).
However,
its
use
predicting
NAFLD
in
patients
with
type
2
diabetes
mellitus
(T2DM)
remains
unclear.
In
this
study,
we
aimed
observe
performance
of
indices
diagnosing
combined
T2DM
compare
their
diagnostic
values
clinical
practice.
Overall,
268
from
Endocrinology
Department
Jiangsu
Provincial
Hospital
Traditional
Chinese
Medicine
were
enrolled
study
divided
into
two
groups:
an
group
(T2DM
NAFLD)
a
without
NAFLD).
General
information
blood
indicators
participants
collected,
calculated
based
on
these
data.
Receiver
operating
characteristic
(ROC)
analysis
was
conducted
calculate
area
under
curve
(AUC)
resistance-related
indices,
aiming
assess
ability
discriminate
between
NAFLD.
ROC
revealed
that
among
five
four
parameters
(TyG,
TyG-body
mass
[BMI],
TyG-waist
circumference
[WC],
TyG-
(waist–hip
ratio
[WHR])
exhibited
high
predictive
identifying
NAFLD,
except
HOMA-IR
(AUCs:0.710,0.738,0.737
0.730,
respectivly).
TyG-BMI
demonstrated
superior
value,
especially
males.
For
males,
AUC
0.764
(95%
confidence
interval
[CI]
0.691–0.827).
sensitivity
specificity
male
90.32%
47.89%,
respectively.
Moreover,
Generalized
linear
regression
models,
there
positive
associations
TyG,
TyG-BMI,
TyG-WC,
TyG-WHR,
controlled
attenuation
parameter
(CAP),
β
21.30,
0.745,
0.247,
2.549
(all
P
<
0.001),
is
promising
predictor
T2DM,
particularly
lean
patients.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Dec. 18, 2024
Metabolic
disease
has
become
a
global
health
concern,
and
insulin
resistance
(IR)
is
crucial
underlying
mechanism
in
various
metabolic
diseases.
This
study
aims
to
compare
the
ability
of
seven
anthropometric
indicators
predicting
IR
Chinese
population,
find
more
sensitive
simple
indicator
for
early
identification
IR.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 14, 2024
Abstract
Background:
The
triglyceride-glucose
(TyG)
index
and
related
parameters,
as
well
Homeostatic
Model
Assessment
for
Insulin
Resistance(HOMA-IR),
are
recently
developed
insulin
resistance
markers,
which
can
identify
the
individuals
with
a
risk
of
non-alcoholic
fatty
liver
disease
(NAFLD).
However,
whether
it
be
used
to
predict
NAFLD
among
patients
type
2
diabetes
mellitus
(T2DM)
remains
unclear.
This
study
aims
observe
performance
indices
in
diagnosing
combined
T2DM,
compare
diagnostic
values
clinical
practice.
Patients
Methods:
268
T2DM
from
Endocrinology
Department
Jiangsu
Provincial
Hospital
Traditional
Chinese
Medicine
were
enrolled
this
study,
they
divided
into
two
groups:
group
(T2DM
NAFLD)
without
NAFLD).
General
information
blood
indicators
pariticipants
collected,
calculated
based
on
data.
Furthermore,
receiver
operating
characteristic
(ROC)
analysis
was
conducted
calculate
area
under
curve
(AUC)
resistance-related
indices.
Results：ROC
revealed
that
five
indices,
four
parameters
(TyG、TyG-BMI、TyG-WC
TyG-WHR)
exhibit
high
predictive
identifying
except
HOMA-IR.
Of
particular,
TyG-BMI
demonstrated
superior
value,
especially
males
BMI
less
than
23
kg/m².
For
male
lean
patients,
AUC
0.764
(95%
CI
0.691
-
0.827)
0.817
0.626
0.937),
respectively.
sensitivity
specificity
90.32%
47.89%.
While
80%
82.6%,
Moreover,
In
fully
adjusted
models,
there
positive
associations
TyG,
TyG-BMI,
TyG-WC,
TyG-WHR
HOMA-IR
CAP,
βs
21.30,
0.745,
0.247
2.549
(all
p<0.001),
Conclusion:
is
promising
patients.
The Lancet Regional Health - Western Pacific,
Journal Year:
2024,
Volume and Issue:
49, P. 101150 - 101150
Published: July 26, 2024
The
prevalence
of
metabolic-associated
steatotic
liver
disease
(MASLD)
is
rising
precipitously
among
children,
particularly
in
regions
or
countries
burdened
with
high
obesity.
However,
identifying
those
at
risk
remains
a
significant
challenge,
as
the
majority
do
not
exhibit
distinct
symptoms
MASLD.
There
an
urgent
need
for
widely
accepted
non-invasive
predictor
to
facilitate
early
diagnosis
and
management
disease.
Our
study
aims
1)
evaluate
compare
existing
predictors
MASLD,
2)
develop
practical
screening
strategy
tailored
local
Therapeutic Advances in Endocrinology and Metabolism,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
The
term
metabolic-associated
fatty
liver
disease
(MAFLD),
with
a
global
prevalence
estimated
at
38.77%,
has
gradually
replaced
the
traditional
concept
of
non-alcoholic
(NAFLD).
Compared
to
general
population,
incidence
MAFLD
is
notably
higher
among
pregnant
women,
posing
potential
risks
both
maternal
and
neonatal
health.
This
review
summarizes
latest
research
on
MAFLD,
focusing
its
association
pregnancy
complications.
Additionally,
it
provides
comparative
analysis
previous
studies
NAFLD,
presenting
comprehensive
perspective
for
clinical
management.
Findings
suggest
that
women
face
risk
gestational
hypertension
cesarean
delivery
compared
those
while
diabetes
mellitus
remains
similar
between
two
conditions.
associated
an
increased
likelihood
delivering
large-for-gestational-age
infants
heightened
preterm
birth
low
weight.
Current
treatment
strategies
focus
lifestyle
modifications,
such
as
dietary
adjustments
physical
activity.
However,
there
urgent
need
development
safe
effective
pharmacological
treatments,
particularly
tailored
toward
women.
Future
should
delve
deeper
into
causal
relationships
complications
explore
optimal
therapeutic
approaches
improve
outcomes
mothers
their
infants.
