Association between life’s essential 8 and male biochemical androgen deficiency: evidence from NHANES 2013–2016

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: June 24, 2024

Purpose To evaluate the association of Life’s Essential 8 (LE8) and its subscales with male biochemical androgen deficiency (MBAD) total testosterone based on data from national health nutrition examination survey (NHANES) database. Methods Data males aged 20 years or older NHANES 2013–2016 were extracted. LE8 score was calculated American Heart Association definitions. Total (TT) values measured in using precise isotope dilution liquid chromatography. MBAD defined as serum TT <300 ng/dL. Univariate multivariable analyses conducted. Propensity matching (PSM) weighted regression after added sensitivity analyses. The generalized additive model, smooth curve fitting, recursive algorithm used to determine potential inflection points. Piecewise models log-likelihood ratio test quantify nonlinear effects. Results A 3094 participants who above included. Out them, 805 diagnosed MBAD. After adjusting confounders independently associated (OR 0.96, P < 0.001) (β 2.7, 0.001). remained robust even PSM. non-linear relationship behaviors revealed. Conclusion an independent protective factor a feasible approach promote endocrine sexual function.

Language: Английский

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The relationship between remnant cholesterol and the risk of testosterone deficiency in US adults: a cross-sectional study based on the NHANES database

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 24, 2024

Testosterone deficiency (TD) is an urgent health issue that requires attention, associated with various adverse outcomes including cardiovascular diseases (CVD) and metabolic syndrome. Remnant cholesterol (RC) has emerged as a potential biomarker for risk, but its relationship testosterone levels TD not been thoroughly investigated. This study aims to explore the association between RC in adult American males using data from National Health Nutrition Examination Survey (NHANES).

Language: Английский

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Association between cardiometabolic index and risk of testosterone deficiency in adult men: a cross-sectional study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 6, 2025

Metabolic health is closely related to testosterone levels, and the cardiometabolic index (CMI) a novel metabolic evaluation metric that encompasses obesity lipid metabolism. However, there currently lack of research on relationship between CMI testosterone, which objective this study. This study utilized data from National Health Nutrition Examination Survey (NHANES) cycles 2011 2016. Only adult males who completed physical measurements, metabolism assessments, measurements were included in final analysis. The exposure variable was analyzed both as continuous categorical divided into quartiles. Testosterone measured using isotope dilution liquid chromatography-tandem mass spectrometry technique. Linear logistic regression analyses used explore total (TT) well risk deficiency (TD). Smooth curve fittings employed visualize their linear relationships. Subgroup conducted evaluate stability our results across different participant characteristics. Finally, ROC analysis assess performance predicting TD. A 2,747 participants analysis, including 552 with TD (20.10%). average sample 1.59 ± 0.03, having higher 2.18 0.08 compared non-TD at 1.46 0.03. Corresponding levels 223.79 3.69 ng/dL 508.36 5.73 ng/dL, respectively. After adjusting for all covariates, showed lower TT (β = -23.84, 95% CI: -33.94, -13.74, p < 0.0001) (OR 1.26, 1.08, 1.48, 0.01). When categorized quartiles Q1 reference, Q4 exhibited significantly -74.04, -106.01, -42.08, 2.34, 1.18, 4.64, 0.02). indicated these variables. confirmed associations population demonstrated had good predictive cut-off value 1.126 an AUC (95% CI) 0.673 (0.649, 0.700). associated TD, it can predict Using early detection timely intervention could reduce disease burden promote reproductive health. Further prospective studies large sizes are needed validate findings.

Language: Английский

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Development of Free Testosterone Chemiluminescence Detection Kit and Its Clinical Application

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Background: Free testosterone makes up only 1–2% of the total in blood, but it is active form and enters cells directly to work. The level substantially affected by sex hormone-binding globulin, whereas free can better reflect actual biological activity. clinical detection levels serum important for diagnosis related diseases, such as male hypogonadism, polycystic ovary syndrome, metabolic osteoporosis, Alzheimer's disease, hypogonadism. However, existing methods have problems, insufficient sensitivity, complex operation, high cost, there an urgent need develop efficient accurate technologies. We aimed a chemiluminescence kit conducted comprehensive performance evaluation. Methods: content was quantified using competitive immunoassay method. Free derivatives competed binding biotinylated testosterone-specific antibodies. reaction procedure determined concentration magnetic beads optimized, antibodies were biotinylated, labeled with acridinium ester, working concentrations both fine-tuned. Following determination process, assay evaluated through series tests assessing linearity, limit blank, accuracy, precision, stability, specificity, relevance. Samples collected from 1615 2035 female patients, their measured. Finally, significance diagnostic applications analyzed. Results: The linear r > 0.99, blank 0.021 pg/mL, accuracy deviation < 5%, imprecision stability lasted 12 months. There no cross-reactivity similar substances. In total, 392 samples analysis methodological comparison conducted. correlation coefficient 0.9941, meeting requirements. patient detection. showed significant differences among patients different diagnoses. Prostate malignancy associated lower levels, other diagnoses (such those hair loss) higher levels. Therefore, could serve reference indicator assessment certain diseases. Conclusion: developed this study exhibited excellent performance, low degree automation. It fully meets requirements When tested on samples, be regarded which help doctors make treatments

Language: Английский

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Associating serum testosterone levels with African ancestral prostate cancer health disparities

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 8, 2025

Language: Английский

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Impact of adolescent high-fat diet and psychosocial stress on neuroendocrine stress responses and binge eating behavior in adult male Lewis rats

Hormones and Behavior, Journal Year: 2025, Volume and Issue: 171, P. 105744 - 105744

Published: April 18, 2025

Language: Английский

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Associating serum testosterone levels with African ancestral prostate cancer health disparities

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Serum testosterone levels decrease in the aging male, while risk for prostate cancer (PCa) increases concomitantly. Higher younger men have been linked with racially driven PCa disparities, African disproportionately impacted. In turn, higher of serum lipids associated aggressive disease, racial disparity between testosterone, cholesterol and mortality has suggested. Having previously reported a 2.1-fold increased age-adjusted Black South over American men, we determined lipid 250 either or without clinicopathologically diagnosed disease. Observing no associations levels, Africans presented 1.24 (< 60 years) 1.3-fold (≥ greater than Americans. Notably, rapid drop total-, bioavailable- free 65 years older was significantly (P = 0.0057, 0.009 0.005, respectively), irrespective age, further advanced disease 0.004, 0.0012 0.0036, respectively). These preliminary data provide insights into potential role androgens driving health important consequence tailoring treatment men.

Language: Английский

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Association between cardiometabolic index and testosterone among adult males: a cross-sectional analysis from National Health and Nutrition Examination Survey 2013–2016

Translational Andrology and Urology, Journal Year: 2024, Volume and Issue: 13(8), P. 1425 - 1435

Published: Aug. 1, 2024

Cardiometabolic index (CMI) is a well-promising indicator for predicting obesity-related diseases. Testosterone decline and deficiency importantly affect men's health, may be associated with obesity excessive deposition of visceral adipose tissue. We aimed to explore the association between CMI serum testosterone in US adult males.

Language: Английский

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Association between cardiometabolic index and testosterone among adult males: A cross- sectional analysis of the National Health and Nutrition Examination Survey 2013-2016

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 16, 2024

Abstract Background Cardiometabolic index (CMI) is a well-promising indicator for predicting obesity-related diseases. Testosterone decline and deficiency importantly affect men's health, may be associated with obesity excessive deposition of visceral adipose tissue. Therefore, this study intends to explore the relationship between CMI testosterone. Methods The present cross-sectional was conducted among adult males complete data about testosterone in 2013–2016 National Health Nutrition Examination Survey (NHANES). Calculate CMI: Triglyceride (TG) (mmol/L)/ High-density lipid-cholesterol (HDL–C) (mmol/L) × waist-to-height Ratio (WHtR). Multivariable regression subgroup analyses were association Results We included 2,209 male participants final analysis. After adjusting confounders, found show negative correlation (Minimally adjusted model: β=-10.56, 95%CI: -12.76, -8.36, P < 0.0001, fully β=-0.04 (-4.88, 4.81), = 0.9882). Multivariate-adjusted beta also showed levels significantly lower two highest groups (Q3, Q4) compared lowest group (Q1). In populations, affected by age, race, Education level, Hypertension, smoking status ( -interaction༜0.05). Furthermore, ROC curve analysis indicated that area under (0.68 (95% CI: (0.65,0.71) more significant than TyG (0.67 0.65,0.70). Conclusion negatively related decreased likelihood United States adults. Our findings simple anthropometric predict

Language: Английский

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Association of geriatric nutritional risk index with total testosterone in elderly adults in the US: evidence from NHANES 2011-2016

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 16, 2024

There is growing evidence that deficiencies in specific nutrients can impact testosterone levels older men. However, research examining the predictive value of overall nutritional status on remains limited. The Geriatric Nutritional Risk Index (GNRI) an effective tool for assessing elderly. Therefore, this study aimed to investigate potential correlation between GNRI and serum total (TT).

Language: Английский

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