A review of common immunotherapy and nano immunotherapy for acute myeloid leukemia DOI Creative Commons
Yaoyao Wang,

Xiancong Yang,

Yalin Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 10, 2025

Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy. Traditional chemotherapy methods not only bring serious side effects, but also lead to high recurrence rate and drug resistance in some patients. However, as an emerging therapeutic strategy, immunotherapy has shown great potential the field of AML treatment recent years. At present, common for include monoclonal antibodies, CAR-T cell therapy, immune checkpoint inhibitors. With deepening research technological progress, especially application nanotechnology medicine, new expected become one important means acute future.

Language: Английский

Non-viral vectors for RNA delivery DOI
Yi Yan, Xiaoyu Liu, Lu An

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 342, P. 241 - 279

Published: Jan. 10, 2022

Language: Английский

Citations

221
Synthesis of green nanoparticles for energy, biomedical, environmental, agricultural, and food applications: A review DOI Creative Commons
Ahmed I. Osman, Yubin Zhang, Mohamed Farghali

et al.

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(2), P. 841 - 887

Published: Jan. 20, 2024

Language: Английский

Citations

174
Ferritin: A Multifunctional Nanoplatform for Biological Detection, Imaging Diagnosis, and Drug Delivery DOI
Ningning Song, Jianlin Zhang, Jiao Zhai

et al.

Accounts of Chemical Research, Journal Year: 2021, Volume and Issue: 54(17), P. 3313 - 3325

Published: Aug. 20, 2021

Ferritins are spherical iron storage proteins within cells that composed of a combination 24 subunits two types, heavy-chain ferritin (HFn) and light-chain (LFn). They autoassemble naturally into hollow nanocage with an outer diameter 12 nm interior cavity is 8 in diameter. In recent years, the constantly emerging safety issues concerns about unfavorable uniformity indefinite vivo behavior traditional nanomedicines, characteristics native nanocages, such as unique structure, excellent profile, definite behavior, make ferritin-based formulations uniquely attractive for nanomedicine development. To date, variety cargo molecules, including therapeutic drugs (e.g., cisplatin, carboplatin, paclitaxel, curcumin, atropine, quercetin, gefitinib, daunomycin, epirubicin, doxorubicin, etc.), imaging agents fluorescence dyes, radioisotopes, MRI contrast agents), nucleic acids siRNA miRNA), metal nanoparticles Fe3O4, CeO2, AuPd, CuS, CoPt, FeCo, Ag, etc.) have been loaded nanocages broad range biomedical applications from vitro biosensing to targeted delivery molecules living systems aid modified targeting ligands either genetically or chemically. We reported human HFn could selectively deliver large amount tumors vivovia transferrin receptor 1 (TfR1)-mediated tumor-cell-specific followed by rapid internalization. By use intrinsic tumor-targeting property structure HFn, cargo-loaded developed biological analysis, diagnosis, medicine view property, lack immunogenicity, holds promise promote drugs, diagnostic agents, moieties multifunctional nanomedicines.Since report we extensively explored ideal nanocarrier tumor-targeted anticancer inorganic nanoparticles, radioisotopes. particular, genetic tools, also engineered recognize broader disease biomarkers. this Account, systematically review ferritins characterizing their tumor-binding understanding mechanism kinetics loading exploring applications. finally discuss prospect become next-generation nanomedicines. expect physicochemical will attract interest fundamental drug research offer new opportunities

Language: Английский

Citations

141
Protein‐based Nanoparticles: From Drug Delivery to Imaging, Nanocatalysis and Protein Therapy DOI Creative Commons

Jonas Kaltbeitzel,

Peter Wich

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(44)

Published: March 14, 2023

Proteins and enzymes are versatile biomaterials for a wide range of medical applications due to their high specificity receptors substrates, degradability, low toxicity, overall good biocompatibility. Protein nanoparticles formed by the arrangement several native or modified proteins into nanometer-sized assemblies. In this review, we will focus on artificial nanoparticle systems, where main structural element not just an encapsulated payload. While under natural conditions, only certain form defined aggregates nanoparticles, chemical modifications change in physical environment can further extend pool available building blocks. This allows assembly many globular even enzymes. These advances preparation methods led emergence new generations nanosystems that beyond transport vehicles diverse applications, from multifunctional drug delivery imaging, nanocatalysis protein therapy.

Language: Английский

Citations

50
Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts DOI Creative Commons

Zhongsong Zhang,

Long Chen

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

Citations

2
Green nanotechnology—An innovative pathway towards biocompatible and medically relevant gold nanoparticles DOI Creative Commons
Velaphi C. Thipe,

Alice Raphael Karikachery,

Pınar Çakılkaya

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 70, P. 103256 - 103256

Published: March 11, 2022

In this review, we focus on recent advances in green nanotechnology, providing details reliable synthetic pathways towards biocompatible and medically relevant gold radioactive nanoparticles. We cover a wide plethora of protocols that utilize nanotechnology with in-depth understanding what makes process green. section 2, provide full the intervention for production various functionalized nanoparticles (AuNPs). Section 3 focuses characterization tools to be used complete physicochemical, size vitro before translating them into potential vivo applications. 4 science applications diagnostic imaging. Specifically, have highlighted importance chemistry physics myriad imaging including X-ray contrast agents, single photon emission computed tomography (SPECT) imaging, positron-emission (PET) optical coherence (OCT), fluorescence magnetic resonance (MRI), surface enhanced Raman spectroscopy (SERS), ultrasound (US) 5 discusses latest drug delivery, photothermal therapy cancer therapy. particular, discuss nanotechnological interventions how electron rich phytochemicals epigallocatechin gallate (EGCG) from tea, mangiferin (MGF) mango allied can utilized their dual roles, as reducing agents well rendering tumor specificity due strong cell receptor avidity—to produce specific molecular agents. also Therapy. Important aspects relating systemic toxicity ways mitigate issues effective implementation biomedical sciences are discussed 6. The topics covered intended answer questions why should use processes is role nanomedicine domain human health hygiene. Most importantly, critical analysis ubiquitous nanomedicine.

Language: Английский

Citations

54
Palladium nanoparticles decorated Chitosan-Pectin modified Kaolin: It’s catalytic activity for Suzuki-Miyaura coupling reaction, reduction of the 4-nitrophenol, and treatment of lung cancer DOI

Marjan Shahriari,

Mohammad Ali Hosseini Sedigh,

Maryam Shahriari

et al.

Inorganic Chemistry Communications, Journal Year: 2022, Volume and Issue: 141, P. 109523 - 109523

Published: April 29, 2022

Language: Английский

Citations

44
A novel view of ferritin in cancer DOI Creative Commons

Bhavyata Shesh,

James R. Connor

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(4), P. 188917 - 188917

Published: May 18, 2023

Language: Английский

Citations

34
Emerging strategies against accelerated blood clearance phenomenon of nanocarrier drug delivery systems DOI Creative Commons

Jianquan Pan,

Yanyan Wang,

Yunna Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 25, 2025

Nanocarrier drug delivery systems (NDDS) have gained momentum in the field of anticancer or nucleic acid due to their capacity aggrandize targeting efficacy and therapeutic outcomes encapsulated drugs. A disadvantage NDDS is that repeated administrations often encounter an obstacle known as "accelerated blood clearance (ABC) phenomenon". This phenomenon results rapid secondary dose from bloodstream markedly augmented liver accumulation, which substantially undermines accurate drugs effect NDDS. Nevertheless, underlying mechanism this has not been elucidated there currently no effective method for its eradication. In light above, aim review provide a comprehensive summary potential countermeasures ABC phenomenon, with view rejuvenating both slow-release property expectation clinic. paper, we innovatively introduce pharmacokinetic further elucidate occurrence after discussing immunological mechanism, provides new direction expanding mechanistic study phenomenon. Whereafter, conducted critical conclusion strategies suppression prevention terms physical structural properties, PEG-lipid derivatives, dosage regimen substances nanoformulations, particularly covering some novel high-performance nanomaterials mixed modification methods. Alternatively, propose promising strategy applying characteristics significantly elevated hepatic accumulation activated CYP3A1 profile associated are proved be conducive enhancing treatment hepatocellular carcinoma. Collectively, instructive surmounting wielding advancing clinical applications translations

Language: Английский

Citations

1
Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications DOI Creative Commons
Ernesto Tinajero‐Díaz, Daniela Salado‐Leza, Carmen González

et al.

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(10), P. 1719 - 1719

Published: Oct. 18, 2021

Metal-based nanoparticles are widely used to deliver bioactive molecules and drugs improve cancer therapy. Several research works have highlighted the synthesis of gold silver by green chemistry, using biological entities minimize use solvents control their physicochemical properties. Recent advances in evaluating anticancer effect biogenic Au Ag mainly focused on conventional 2D cell culture vivo murine models that allow determination half-maximal inhibitory concentration, a critical parameter move forward clinical trials. However, interaction between tumor microenvironment is not yet fully understood. Therefore, it necessary develop more human-like evaluation or existing ones for better understanding molecular bases cancer. This review provides recent biosynthesized seven most common relevant cancers assessment. In addition, general idea silico, vitro, ex vivo, metal-based nanoparticles.

Language: Английский

Citations

50