Hybrid Nanomaterials for Cancer Immunotherapy

Advanced Science, Journal Year: 2022, Volume and Issue: 10(6)

Published: Dec. 25, 2022

Abstract Nano‐immunotherapy has been recognized as a highly promising strategy for cancer treatment in recent decades, which combines nanotechnology and immunotherapy to combat against tumors. Hybrid nanomaterials consisting of at least two constituents with distinct compositions properties, usually organic inorganic, have engineered integrated functions enormous potential boosting immunotherapy. This review provides summary hybrid reported immunotherapy, including nanoscale metal–organic frameworks, metal–phenolic networks, mesoporous organosilica nanoparticles, metallofullerene nanomaterials, polymer–lipid, biomacromolecule‐based nanomaterials. The combination chemotherapy, chemodynamic therapy, radiotherapy, radiodynamic photothermal photodynamic sonodynamic therapy based on is also discussed. Finally, the current challenges prospects designing their application are outlined.

Language: Английский

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Multifunctional nanoparticle for cancer therapy

MedComm, Journal Year: 2023, Volume and Issue: 4(1)

Published: Jan. 11, 2023

Cancer is a complex disease associated with combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment diagnosis for cancer, current strategies simultaneously focus on various tumor targets. Based the rapid development nanotechnology, nanocarriers have been shown to exhibit excellent potential cancer therapy. Compared nanoparticles single functions, multifunctional are believed be more aggressive potent context targeting. However, not simply an upgraded version original function, but involves sophisticated system proper backbone, optimized modification sites, simple preparation method, efficient function integration. Despite this, many well-designed promising therapeutic emerged recently. Here, give detailed understanding analyzation currently developed nanoparticles, their platform structures organic or inorganic backbones were systemically generalized. We emphasized functionalization strategies, which additional functions nanoparticle. also discussed application that involved nanoformulations functional crosstalk. This review thus provides overview construction advances nanoparticles.

Language: Английский

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Biomimetic Nano-Drug Delivery System: An Emerging Platform for Promoting Tumor Treatment

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 571 - 608

Published: Jan. 1, 2024

Abstract: With the development of nanotechnology, nanoparticles (NPs) have shown broad prospects as drug delivery vehicles. However, they exhibit certain limitations, including low biocompatibility, poor physiological stability, rapid clearance from body, and nonspecific targeting, which hampered their clinical application. Therefore, novel systems with improved biocompatibility high target specificity remains a major challenge. In recent years, biofilm mediated biomimetic nano-drug system (BNDDS) has become research hotspot focus in field life sciences. This new platform uses bio-nanotechnology to encapsulate synthetic NPswithin membrane, organically integrating immunogenicity, toxicity, tumor good adjustability versatility nanocarrier, shows promising applications precision therapy. this review, we systematically summarize progress BNDDS used for optimizing delivery, providing theoretical reference designing safe efficient treatment strategies improve outcomes. Keywords: nanoparticles, cell targeted therapy

Language: Английский

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Cell Membrane-Coated Biomimetic Nanoparticles in Cancer Treatment

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 531 - 531

Published: April 12, 2024

Nanoparticle-based drug delivery systems hold promise for cancer treatment by enhancing the solubility and stability of anti-tumor drugs. Nonetheless, challenges inadequate targeting limited biocompatibility persist. In recent years, cell membrane nano-biomimetic have emerged as a focal point research development, due to their exceptional traits, including precise targeting, low toxicity, good biocompatibility. This review outlines categorization advantages bionic nano-delivery systems, provides an introduction preparation methods, assesses applications in treatment, chemotherapy, gene therapy, immunotherapy, photodynamic photothermal combination therapy. Notably, delves into application various identifies opportunities future advancement. Embracing membrane-coated biomimetic nanoparticles presents novel unparalleled avenue personalized tumor

Language: Английский

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Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects

Experimental Hematology and Oncology, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 31, 2025

Liposomes and lipid nanoparticles are common lipid-based drug delivery systems play important roles in cancer treatment vaccine manufacture. Although significant progress has been made with these nanocarriers recent years, efficient clinical translation of active targeted liposomal remains extremely challenging. In this review, we focus on liposomes, stimuli-responsive strategy combined therapy treatment. We also summarize advances liposome nanoparticle applications nucleic acid tumor vaccination. addition, discuss limitations challenges the nanomaterials make recommendations for future research therapy.

Language: Английский

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Brain-Targeting Drug Delivery Systems: The State Of The Art In Treatment Of Glioblastoma

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101443 - 101443

Published: Jan. 5, 2025

Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and poor prognosis. The blood-brain barrier (BBB) blood-tumor (BTB) present significant obstacles to efficacy of tumor-targeted pharmacotherapy, thereby impeding therapeutic potential numerous candidate drugs. Targeting delivery adequate doses drug across BBB treat GBM has become prominent research area in recent years. This emphasis driven exploration evaluation diverse technologies for with some already undergoing clinical trials. review provides thorough overview advancements challenges targeted treatment. It specifically emphasizes systemic administration strategies assess their limitations Furthermore, this highlights promising future directions development intelligent systems aimed at overcoming current enhancing against GBM. These not only support foundational on but also offer methodological approaches applications.

Language: Английский

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Nanosuspensions technology as a master key for nature products drug delivery and In vivo fate

European Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 185, P. 106425 - 106425

Published: March 18, 2023

The drug nanosuspensions is a universal formulation approach for improved delivery of hydrophobic drugs and one the most promising approaches increasing biopharmaceutical performance poorly water-soluble substances, especially nature products. This review aimed to summarize preparation main technological difficulties encountered in development, such as guidelines stabilizers screening, vivo fate intravenously administrated nanosuspensions, how realize target was reviewed. Furthermore, challenges products also discussed commented. Therefore, it hoped provide reference assistance production, usage, predictability controllability targeting nanosuspensions.

Language: Английский

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Cell-Membrane-Coated Nanoparticles for Targeted Drug Delivery to the Brain for the Treatment of Neurological Diseases

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 621 - 621

Published: Feb. 13, 2023

Neurological diseases (NDs) are a significant cause of disability and death in the global population. However, effective treatments still need to be improved for most NDs. In recent years, cell-membrane-coated nanoparticles (CMCNPs) as drug-targeting delivery systems have become research hotspot. Such membrane-derived, nano drug-delivery system not only contributes avoiding immune clearance but also endows (NPs) with various cellular functional mimicries. This review article first provides an overview function mechanism single/hybrid cell-membrane-derived NPs. Then, we highlight application safety CMCNPs Finally, discuss challenges opportunities field.

Language: Английский

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Hybrid Membrane‐Coated Nanoparticles for Precise Targeting and Synergistic Therapy in Alzheimer's Disease

Advanced Science, Journal Year: 2024, Volume and Issue: 11(24)

Published: April 22, 2024

Abstract The blood brain barrier (BBB) limits the application of most therapeutic drugs for neurological diseases (NDs). Hybrid cell membrane‐coated nanoparticles derived from different types can mimic surface properties and functionalities source cells, further enhancing their targeting precision efficacy. Neuroinflammation has been increasingly recognized as a critical factor in pathogenesis various NDs, especially Alzheimer's disease (AD). In this study, novel membrane coating is designed by hybridizing platelets chemokine (C–C motif) receptor 2 (CCR2) cells are overexpressed to cross BBB target neuroinflammatory lesions. Past unsuccessful endeavors AD drug development underscore challenge achieving favorable outcomes when utilizing single‐mechanism drugs.Two with mechanisms actions into liposomes successfully loaded realize multitargeting treatment. transgenic mouse model familial (5xFAD), administration these drug‐loaded hybrid results significant reduction amyloid plaque deposition, neuroinflammation, cognitive impairments. Collectively, nanomaterials offer new opportunities precise delivery disease‐specific targeting, which represent versatile platform targeted therapy AD.

Language: Английский

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Immune cells: potential carriers or agents for drug delivery to the central nervous system

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: March 29, 2024

Abstract Drug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery. However, access nanoparticles/drugs to central nervous system (CNS) remains challenge mainly due obstruction from brain barriers. Immune cells infiltrating CNS in pathological state inspired development strategies foundation Herein, we outline three major barriers mechanisms by which immune migrate across blood–brain barrier. We subsequently review biomimetic utilizing cell-based nanoparticles CNS, well recent progress rationally engineering DDS diseases. Finally, discuss challenges opportunities diseases promote their clinical development.

Language: Английский

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