Nanoarchitecting intelligently encapsulated designs for improved cancer therapy DOI Creative Commons

Ying‐Tong Ye,

Hong‐Ying Xia,

Jie Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

Despite the success in exploring various aspects of origination and therapeutic strategies, cancer has remained one most dreadful metabolic disorders due to failure eradicate tumors comprehensively frequent recurrence because acquired resistance drugs. Recently, several advancements have been evidenced fabrication smart nanocarriers encapsulated with multiple components. Several reasons for nanoencapsulation include enhancement bioavailability drugs, precise targetability reduce adverse effects on normal cells, ability enable controlled drug release rates at tumor sites. In addition, these protect cargo from deactivation, responsively delivering it based physiological or pathological characteristics tumors. this review, we present approaches therapy, including organic materials, inorganic components, their composites, as well biomembrane-based strategies. These along practical applications potential treatment, are discussed depth, highlighting advantages disadvantages, aiming reveal ultimate prospects enhancing delivery efficiency targeted therapy.

Language: Английский

Advances and applications of nanoparticles in cancer therapy DOI Creative Commons

Xianzhou Huang,

Tao He, Xiuqi Liang

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

Citations

28
Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds DOI
Yafei Zhang, Yuning Zhang, Rui Ding

et al.

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Jan. 12, 2024

Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application

Language: Английский

Citations

18
Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies DOI Creative Commons
Xia Wang,

Jinlei Peng,

Chi Meng

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(31), P. 12234 - 12257

Published: Jan. 1, 2024

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have made improve the PDT effect in terms of safety efficiency. In this review, we highlight recent advances innovative strategies for enhanced PDT, including (1) development novel radicals, (2) design activatable photosensitizers based on TME light, (3) photocatalytic NADH oxidation damage mitochondrial electron transport chain. Additionally, new mechanisms are also presented an inspiration PSs. Finally, discuss current challenges future prospects clinical practice these strategies. It is hoped that review will provide angle understanding relationship between intratumoural redox environment mechanisms, ideas smart systems.

Language: Английский

Citations

17
Red emitting carbon dots: surface modifications and bioapplications DOI Creative Commons

Dawson Benner,

Pankaj Yadav, Dhiraj Bhatia

et al.

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(17), P. 4337 - 4353

Published: Jan. 1, 2023

Quantum dots (QDs), and carbon quantum (CDs) in particular, have received significant attention for their special characteristics. These particles, on the scale of several nanometers, are often produced using simple green methods, with naturally occurring organic precursors. In addition to facile production CDs present advantageous applications field medicine, primarily bioimaging, antibacterial therapeutics. Also, great potential surface modification through methods like doping or material mixing during synthesis. However, bulk current literature focuses emitting blue wavelengths which not very suitable biological applications. Red therefore additional interest due brightness, photostability, novelty deeper tissue penetration. this review article, red CDs, production, translational research explored depth, emphasis effects modifications doping.

Language: Английский

Citations

23
Modulating Intracellular Dynamics for Optimized Intracellular Release and Transcytosis Equilibrium DOI

Guiping Yuan,

Minghui Li, Yifan Zhang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(25)

Published: April 4, 2024

Active transcytosis-mediated nanomedicine transport presents considerable potential in overcoming diverse delivery barriers, thereby facilitating tumor accumulation and penetration. Nevertheless, the persistent challenge lies achieving a nuanced equilibrium between intracellular interception for drug release transcytosis In this study, comprehensive exploration is conducted involving series of polyglutamine-paclitaxel conjugates featuring distinct hydrophilic/hydrophobic ratios (HHR) tertiary amine-oxide proportions (TP) (OPGA-PTX). The screening process, meticulously focused on delineating their subcellular distribution, capability, penetration, unveils particularly promising candidate denoted as OPPX, characterized by an HHR 10:1 TP 100%. distinguished its rapid cellular internalization through multiple endocytic pathways, selectively engages trafficking to Golgi apparatus facilitate within penetration throughout tissues simultaneously sorted lysosomes cathepsin B-activated release. This study not only identifies OPPX exemplary but also underscores feasibility modulating distribution optimize active capabilities mechanisms nanomedicines, providing alternative approach designing efficient anticancer nanomedicines.

Language: Английский

Citations

10
Nanomaterial-based regulation of redox metabolism for enhancing cancer therapy DOI

Xiaodan Jia,

Yue Wang, Yue Qiao

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.

Language: Английский

Citations

9
Surface Functionalization of Nanocarriers with Anti-EGFR Ligands for Cancer Active Targeting DOI Creative Commons

Alessandra Spada,

Sandrine Gerber‐Lemaire

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(3), P. 158 - 158

Published: Jan. 21, 2025

Active cancer targeting consists of the selective recognition overexpressed biomarkers on cell surfaces or within tumor microenvironment, enabled by ligands conjugated to drug carriers. Nanoparticle (NP)-based systems are highly relevant for such an approach due their large surface area which is amenable a variety chemical modifications. Over past decades, several studies have debated efficiency passive targeting, highlighting active as more specific and approach. The choice conjugation chemistry attaching nanocarriers critical ensure stable robust system. Among panel biomarkers, epidermal growth factor receptor (EGFR) stands one most frequently receptors in different types. design development with surface-bound anti-EGFR vital targeted therapy, relying facilitated capture EGFR-overexpressing cells enabling receptor-mediated endocytosis improve accumulation microenvironment. In this review, we examine examples recent significant explore various strategies NP functionalization biomolecules small molecular ligands. addition, also describe some common characterization techniques confirm analyze patterns.

Language: Английский

Citations

1
Nanoparticle accumulation and penetration in 3D tumor models: the effect of size, shape, and surface charge DOI Creative Commons
Pierre Cybulski, María Loreto Bravo, Jim Jui‐Kai Chen

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 24, 2025

Preclinical studies have demonstrated that nanoparticles (NPs) hold significant potential for advancing cancer therapy by enhancing therapeutic efficacy while reducing side effects. Their effectiveness in solid tumors is, however, often constrained insufficient accumulation and penetration. Understanding how the physicochemical properties of NPs – such as size, shape, surface charge influence their interaction with cells within tumor is critical optimizing NP design. In this study, we addressed challenge inconsistent behavior systematically evaluating uptake both 2D 3D models, penetration spheroids. Our results showed larger exhibited higher internalization rates models but limited Furthermore, negatively charged consistently achieved superior deeper than neutral positively NPs. Spherical outperformed rod-shaped These findings underscore importance carefully tailoring to complex microenvironment improved outcomes real tumors.

Language: Английский

Citations

1
Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases DOI Creative Commons
Adriana Jiménez, Enrique Estudillo, Mara A. Guzmán‐Ruiz

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 281 - 281

Published: Feb. 20, 2025

The blood–brain barrier (BBB) is a critical structure that maintains brain homeostasis by selectively regulating nutrient influx and waste efflux. Not surprisingly, it often compromised in neurodegenerative diseases. In addition to its involvement these pathologies, the BBB also represents significant challenge for drug delivery into central nervous system. Nanoparticles (NPs) have been widely explored as carriers capable of overcoming this effectively transporting therapies brain. However, their potential directly address ameliorate dysfunction has received limited attention. review, we examine how NPs enhance across treat diseases explore emerging strategies restore integrity vital structure.

Language: Английский

Citations

1
Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy DOI
Chan Ho Kim, Kyu Eun Lee, Hyewon Ko

et al.

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1088 - 1112

Published: Jan. 29, 2024

Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as promising approach for counteracting evasive tactics of cancer cells. This study delves into innovative realm stimuli-responsive polymeric nanomedicines in context immunotherapy. By capitalizing on intricate landscape tumor microenvironment (TME), which orchestrates suppression and progression, offer tailored strategy enhance therapeutic interventions. The aberrant features TME, include factors such low pH, inflammation, oxidative stress, enzyme overexpression, serve triggers intelligent delivery systems facilitated by functional polymers. dynamic potential overcome challenges faced traditional nanoparticle-based immunotherapy techniques, presenting platform precisely optimize drug within locale. As synergistic interaction between TME unfolds, novel horizon emerges advance efficacy while mitigating its associated limitations.

Language: Английский

Citations

8