A review on reactive oxygen species (ROS)-inducing nanoparticles activated by uni- or multi-modal dynamic treatment for oncotherapy

Nanoscale, Journal Year: 2023, Volume and Issue: 15(28), P. 11813 - 11833

Published: Jan. 1, 2023

The multi-modal therapy has superior anti-tumor efficacy to the uni-modal using nanoparticles inducing reactive oxygen species (ROS). multi-component nature of cold atmospheric plasma (CAP) enables excitation with a single treatment.

Language: Английский

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Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102386 - 102386

Published: July 13, 2024

Language: Английский

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Defect Engineering of Biodegradable Sulfide Nanocage Sonozyme Systems Enables Robust Immunotherapy Against Metastatic Cancers

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Abstract It is important but challenging to innovate inorganic sonosensitizers with controlled biodegradability and enhanced sonodynamic chemodynamic activities harness remodel the immunosuppressive tumor microenvironment (TME) for awakening robust immune responses against metastatic cancers. Herein rational design defect engineering strategy of a pH‐responsive biodegradable sonozyme system in sulfide nanocages augmented cancer immunotherapy reported. A series highly defective Co 9 S 8‐x elevated sulfur‐vacancy (V ) levels are fabricated systematically explore V ‐dependent properties by regulating weight ratio sulfur cobalt source. The bandgap substantially reduced from 2.06 1.54 eV, atomic 2+ 3+ increased 1.53 1.97. Therefore, sonodynamic, chemodynamic, antitumor dramatically system. slow degradation slightly acid TME size targeting infiltration, while exerting slight influence on performance. As result, satisfactory therapeutic effects eradication primary, distant, tumors can be achieved. This work highlights potential strategies combating

Language: Английский

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Newly developed gas-assisted sonodynamic therapy in cancer treatment

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 13(7), P. 2926 - 2954

Published: Dec. 31, 2022

Sonodynamic therapy (SDT) is an emerging noninvasive treatment modality that utilizes low-frequency and low-intensity ultrasound (US) to trigger sensitizers kill tumor cells with reactive oxygen species (ROS). Although SDT has attracted much attention for its properties including high specificity deep tissue penetration, anticancer efficacy still far from satisfactory. As a result, new strategies such as gas-assisted have been proposed further promote the effectiveness of SDT. In this review, mechanisms are first summarized. Then, applications cancer introduced categorized by gas types. Next, therapeutic systems can realize real-time imaging presented. Finally, challenges perspectives future clinical discussed.

Language: Английский

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Stimuli-responsive nanozymes for biomedical applications

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(17), P. 5769 - 5780

Published: Jan. 1, 2023

Stimuli-responsive nanozymes with stimuli-switchable catalytic activities or stimuli-responsive release behaviors have unique applications in the fields of tumor therapy, antibacterial biosensing and anti-inflammatory therapy.

Language: Английский

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