European Journal of Neuroscience,
Journal Year:
2023,
Volume and Issue:
58(1), P. 2194 - 2214
Published: May 11, 2023
Abstract
It
has
been
confirmed
that
BTB
domain
and
CNC
homologue
1
(BACH1)
are
involved
in
ferroptosis‐related
diseases.
However,
the
function
of
BACH1
cerebral
ischemia–reperfusion
injury
(CIRI)‐induced
ferroptosis
remains
to
be
largely
unrevealed.
First,
analysis
differentially
expressed
genes
CIRI
based
on
GEO
dataset
GSE119121
revealed
was
upregulated
CIRI.
level
prominently
increased
middle
artery
occlusion
(MCAO)/reperfusion
model
oxygen–glucose
deprivation/reoxygenation
cell
model.
Further,
knock‐down
markedly
reduced
iron
ion
concentration,
ROS
production,
4‐HNE
lipid
peroxidation
levels
facilitated
GSH
content,
viability
protein
GPX4
SLC7A11,
while
an
pcDNA‐KDM4C
or
pcDNA‐COX2
combined
with
siRNA
could
not
enhance
this
effect.
Mechanistically,
bound
KDM4C
promoter
transcriptionally
activate
its
expression.
Besides,
occupy
locus
COX2
gene,
promoting
expression
by
eliminating
H3K9me3.
Overexpression
overturned
effects
inhibition.
In
vivo
findings
displayed
brain
infraction,
pathological
damage
neuronal
loss
rate
MCAO
mice
were
conspicuously
decreased
after
knock‐down.
This
study
reveals
encourages
neuroblastoma
cells
mouse
tissues
activating
KDM4C‐mediated
demethylation.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: June 10, 2024
This
comprehensive
review
inspects
the
therapeutic
potential
of
mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
across
multiple
organ
systems.
Examining
their
impact
on
integumentary,
respiratory,
cardiovascular,
urinary,
and
skeletal
systems,
study
highlights
versatility
MSC-EVs
in
addressing
diverse
medical
conditions.
Key
pathways,
such
as
Nrf2/HO-1,
consistently
emerge
central
mediators
antioxidative
anti-inflammatory
effects.
From
expediting
diabetic
wound
healing
to
mitigating
oxidative
stress-induced
skin
injuries,
alleviating
acute
lung
even
offering
solutions
for
conditions
like
myocardial
infarction
renal
ischemia-reperfusion
injury,
demonstrate
promising
efficacy.
Their
adaptability
different
administration
routes
identifying
specific
factors
opens
avenues
innovative
regenerative
strategies.
positions
candidates
future
clinical
applications,
providing
a
overview
medicine.
International Immunopharmacology,
Journal Year:
2024,
Volume and Issue:
128, P. 111545 - 111545
Published: Jan. 19, 2024
Liver
ischemia–reperfusion
injury
(IRI)
remains
a
common
issue
and
with
the
increasing
incidence
of
Nonalcoholic
fatty
liver
disease
(NAFLD),
which
are
more
sensitive
to
IRI,
it
is
crucial
explore
possible
strategy
alleviate
steatotic
IRI.
Several
modes
cell
death
involved
in
hepatocytes
immune
cells
during
hepatic
effects
different
inhibitors
including
apoptosis,
necroptosis,
pyroptosis,
ferroptosis
IRI
have
not
been
investigated.
We
established
70%
model
on
mice.
Apoptosis,
pyroptosis
were
used
evaluate
their
injury,
inflammatory
response,
infiltration.
Immunofluorescence
immunohistochemical
results
demonstrated
that
there
progression
liver.
All
four
types
showed
protective
effects,
but
inhibitor
Fer-1
VX765
exerted
better
compared
apoptosis
Z-VAD
necroptosis
Nec-1.
Further,
we
found
occurred
mainly
macrophages
occured
primarily
Ferroptosis
heaptocytes
two
major
inhibiting
these
good
effects.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(17), P. 13336 - 13336
Published: Aug. 28, 2023
As
a
novel
form
of
regulated
cell
death,
ferroptosis
is
characterized
by
intracellular
iron
and
lipid
peroxide
accumulation,
which
different
from
other
death
forms
morphologically,
biochemically,
immunologically.
Ferroptosis
metabolism,
antioxidant
defense
systems
as
well
various
transcription
factors
related
signal
pathways.
Emerging
evidence
has
highlighted
that
associated
with
many
physiological
pathological
processes,
including
cancer,
neurodegeneration
diseases,
cardiovascular
ischemia/reperfusion
injury.
Noncoding
RNAs
are
group
functional
RNA
molecules
not
translated
into
proteins,
can
regulate
gene
expression
in
manners.
An
increasing
number
studies
have
shown
noncoding
RNAs,
especially
miRNAs,
lncRNAs,
circRNAs,
interfere
the
progression
modulating
ferroptosis-related
genes
or
proteins
directly
indirectly.
In
this
review,
we
summarize
basic
mechanisms
regulations
focus
on
recent
mechanism
for
types
ncRNAs
to
conditions,
will
deepen
our
understanding
regulation
provide
new
insights
employing
ferroptosis-associated
therapeutic
strategies.
European Journal of Neuroscience,
Journal Year:
2023,
Volume and Issue:
58(1), P. 2194 - 2214
Published: May 11, 2023
Abstract
It
has
been
confirmed
that
BTB
domain
and
CNC
homologue
1
(BACH1)
are
involved
in
ferroptosis‐related
diseases.
However,
the
function
of
BACH1
cerebral
ischemia–reperfusion
injury
(CIRI)‐induced
ferroptosis
remains
to
be
largely
unrevealed.
First,
analysis
differentially
expressed
genes
CIRI
based
on
GEO
dataset
GSE119121
revealed
was
upregulated
CIRI.
level
prominently
increased
middle
artery
occlusion
(MCAO)/reperfusion
model
oxygen–glucose
deprivation/reoxygenation
cell
model.
Further,
knock‐down
markedly
reduced
iron
ion
concentration,
ROS
production,
4‐HNE
lipid
peroxidation
levels
facilitated
GSH
content,
viability
protein
GPX4
SLC7A11,
while
an
pcDNA‐KDM4C
or
pcDNA‐COX2
combined
with
siRNA
could
not
enhance
this
effect.
Mechanistically,
bound
KDM4C
promoter
transcriptionally
activate
its
expression.
Besides,
occupy
locus
COX2
gene,
promoting
expression
by
eliminating
H3K9me3.
Overexpression
overturned
effects
inhibition.
In
vivo
findings
displayed
brain
infraction,
pathological
damage
neuronal
loss
rate
MCAO
mice
were
conspicuously
decreased
after
knock‐down.
This
study
reveals
encourages
neuroblastoma
cells
mouse
tissues
activating
KDM4C‐mediated
demethylation.
