Antibiotics and Bacterial Resistance—A Short Story of an Endless Arms Race

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5777 - 5777

Published: March 17, 2023

Despite the undisputed development of medicine, antibiotics still serve as first-choice drugs for patients with infectious disorders. The widespread use results from a wide spectrum their actions encompassing mechanisms responsible for: inhibition bacterial cell wall biosynthesis, disruption membrane integrity, suppression nucleic acids and/or proteins synthesis, well disturbances metabolic processes. However, availability antibiotics, accompanied by overprescription, acts double-edged sword, since overuse misuse leads to growing number multidrug-resistant microbes. This, in turn, has recently emerged global public health challenge facing both clinicians and patients. In addition intrinsic resistance, bacteria can acquire resistance particular antimicrobial agents through transfer genetic material conferring resistance. Amongst most common strategies are: drug target site changes, increased permeability antibiotic inactivation, efflux pumps. A better understanding interplay between defense against is crucial developing new or combinations. Herein, we provide brief overview current nanomedicine-based that aim improve efficacy antibiotics.

Language: Английский

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Antimicrobial Drug Resistance in Poultry Production: Current Status and Innovative Strategies for Bacterial Control

Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 953 - 953

Published: April 6, 2023

The world population’s significant increase has promoted a higher consumption of poultry products, which must meet the specified demand while maintaining their quality and safety. It is well known that conventional antimicrobials (antibiotics) have been used in livestock production, including poultry, as preventive measure against or for treatment infectious bacterial diseases. Unfortunately, use misuse these compounds led to development dissemination antimicrobial drug resistance, currently serious public health concern. Multidrug-resistant bacteria are on rise, being responsible infections humans animals; hence, goal this review discuss consequences resistance focusing current status agroeconomic sector. Novel control strategies under investigation application industry also described. These innovative approaches include peptides, bacteriophages, probiotics nanoparticles. Challenges related methods discussed.

Language: Английский

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Alternatives Therapeutic Approaches to Conventional Antibiotics: Advantages, Limitations and Potential Application in Medicine

Antibiotics, Journal Year: 2022, Volume and Issue: 11(12), P. 1826 - 1826

Published: Dec. 16, 2022

Resistance to antimicrobials and particularly multidrug resistance is one of the greatest challenges in health system nowadays. The continual increase rates antimicrobial worldwide boosted by ongoing COVID-19 pandemic poses a major public threat. Different approaches have been employed minimize effect control this threat, but question still lingers as their safety efficiency. In context, new anti-infectious against are being examined. Use antibiotics combination with β-lactamase inhibitors, phage therapy, peptides, nanoparticles, antisense therapeutics considered such promising approach for overcoming bacterial resistance. review, we provide insights into these emerging alternative therapies that currently evaluated which may be developed future break progression We focus on advantages limitations potential application medicine. further highlight importance therapy approach, wherein two or more used order effectively combat infectious disease increasing access quality healthcare. These advances could give an alternate solution overcome drug eventually hope useful information clinicians who seeking solutions problems caused

Language: Английский

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Bioinspired silver nanoparticle-based nanocomposites for effective control of plant pathogens: A review

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168318 - 168318

Published: Nov. 11, 2023

Language: Английский

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Methicillin Resistant Staphylococcus aureus: Molecular Mechanisms Underlying Drug Resistance Development and Novel Strategies to Combat

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 7641 - 7662

Published: Dec. 1, 2023

Antimicrobial resistance (AMR) represents a major threat to global health. Infection caused by Methicillin-resistant Staphylococcus aureus (MRSA) is one of the well-recognized public health problem globally. In some regions, as many 90% S. infections are reported be MRSA, which cannot treated with standard antibiotics. WHO reports indicated that MRSA circulating in every province worldwide, significantly increasing risk death 64% compared drug-sensitive forms infection attributed its antibiotic resistance. The emergence and spread antibiotic-resistant strains have contributed increased prevalence both healthcare community settings. methicillin due expression penicillin-binding protein 2a (PBP2a), renders it impervious action β-lactam antibiotics including methicillin. other through production beta-lactamases. Although treatment options for limited, there promising alternatives combat infections. Innovative therapeutic strategies wide range activity modes yet explored. review highlights challenges posed elucidates mechanisms underlying development, explores mitigation strategies. Furthermore, focuses on alternative therapies such bacteriophages, immunotherapy, nanobiotics, antimicrobial peptides, emphasizing their synergistic effects efficacy against MRSA. By examining these approaches, this provides insights into potential tackling combatting escalating AMR. Ultimately, multifaceted approach encompassing conventional novel interventions imperative mitigate impact ensure sustainable future healthcare.

Language: Английский

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Nanotheranostics to target antibiotic-resistant bacteria: Strategies and applications

OpenNano, Journal Year: 2023, Volume and Issue: 11, P. 100138 - 100138

Published: March 5, 2023

Various health agencies, such as the European Medical Agency (EMA), Centers for Disease Control and Prevention (CDC), World Health Organization (WHO), timely cited upsurge of antibiotic resistance a severe threat to public global economy. Importantly, there is rise in nosocomial infections among covid-19 patients in-hospitalized with delineating disorder. Most are related bacteria residing biofilm, which commonly formed on material surfaces. In biofilms, microcolonies various live syntropy; therefore, their require higher dosage or cocktail broad-spectrum antibiotics, aggravating severity resistance. Notably, lack intrinsic antibacterial properties commercial-grade materials desires develop newer functionalized prevent biofilm formation To devise strategies, prepared at nanoscale demonstrated reasonable enhanced activity antimicrobial agents (that encapsulated/chemically onto surface). this manuscript, we compiled nanosized materials, specifying role targeting specific strains bacteria. We also enlisted examples nanomaterials, nanodevice, nanomachines, nano-camouflaging, nano-antibiotics bactericidal possible clinical implications.

Language: Английский

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Catalyzing innovation: Exploring iron oxide nanoparticles - Origins, advancements, and future application horizons

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 507, P. 215750 - 215750

Published: Feb. 29, 2024

Language: Английский

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Mode of Action of Biogenic Silver, Zinc, Copper, Titanium and Cobalt Nanoparticles Against Antibiotics Resistant Pathogens

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(4), P. 1417 - 1451

Published: Jan. 9, 2024

Language: Английский

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CRISPR-Microfluidics Nexus: Advancing Biomedical Applications for Understanding and Detection

Sensors and Actuators A Physical, Journal Year: 2024, Volume and Issue: 376, P. 115625 - 115625

Published: June 24, 2024

The integration of CRISPR technology with microfluidic-based biosensors has greatly expanded its applications in medicine and molecular biology. This combination offers enhanced sensitivity selectivity medical diagnostics. CRISPR-powered microfluidics enables the accurate quantification DNA RNA associated diseases such as cancer, viral infections, bacterial diseases. precise targeting capabilities allow for detection specific genetic sequences, aiding early diagnosis, disease monitoring, treatment assessment. improves specificity by leveraging programmable nature coupling it signal readouts. However, challenges assay optimization, standardization, device fabrication need to be addressed. Additionally, complexity presents potential limitations terms off-target effects unintended modifications. Overall, holds tremendous diagnostics, but further research development are required fully exploit benefits clinical settings.

Language: Английский

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Synergizing Nanomaterials and Artificial Intelligence in Advanced Optical Biosensors for Precision Antimicrobial Resistance Diagnosis

ACS Synthetic Biology, Journal Year: 2024, Volume and Issue: 13(6), P. 1600 - 1620

Published: June 6, 2024

Antimicrobial resistance (AMR) poses a critical global One Health concern, ensuing from unintentional and continuous exposure to antibiotics, as well challenges in accurate contagion diagnostics. Addressing AMR requires strategic approach that emphasizes early stage prevention through screening clinical, environmental, farming, livestock settings identify nonvulnerable antimicrobial agents the associated genes. Conventional diagnostics, like antibiotic susceptibility testing, possess drawbacks, including high costs, time-consuming processes, significant manpower requirements, underscoring need for intelligent, prompt, on-site diagnostic techniques. Nanoenabled artificial intelligence (AI)-supported smart optical biosensors present potential solution by facilitating rapid point-of-care detection with real-time, sensitive, portable capabilities. This Review comprehensively explores various types of nanobiosensors, such surface plasmon resonance sensors, whispering-gallery mode coherence tomography, interference reflection imaging surface-enhanced Raman spectroscopy, fluorescence microring tweezer biosensors, By harnessing unique advantages these nanoenabled revolutionary paradigm shift diagnostics can be achieved, characterized results, sensitivity, portability, integration Internet-of-Things (IoT) technologies. Moreover, enable personalized monitoring detection, significantly reducing turnaround time eliminating human resources needed sample preservation transportation. Their holistic environmental surveillance further enhances capabilities diverse settings, leading improved modern-age healthcare practices more effective management treatments. Embracing advanced tools promises bolster capacity combat safeguard Health.

Language: Английский

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