Lab on a Chip, Journal Year: 2024, Volume and Issue: 25(6), P. 1404 - 1415
Published: Dec. 28, 2024
A 3D-printed optical-electrochemical microfluidic device able to automatically flow and measure dissolved oxygen in physiologically relevant levels.
Language: Английский
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Aug. 3, 2024
Within the scope of this investigation, we carried out experiments to investigate potential Vision Transformer (ViT) in field medical image analysis. The diagnosis osteoporosis through inspection X-ray radio-images is a substantial classification problem that were able address with assistance models. In order provide basis for comparison, conducted parallel analysis which sought solve same by employing traditional convolutional neural networks (CNNs), are well-known and commonly used techniques solution categorization issues. findings our research led us conclude ViT capable achieving superior outcomes compared CNN. Furthermore, provided methods have access sufficient quantity training data, probability increases both arrive at more appropriate solutions critical
Language: Английский
Citations
19
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125186 - 125186
Published: Jan. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Language: Английский
Citations
7
Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: Jan. 31, 2025
Language: Английский
Citations
5
European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117357 - 117357
Published: Feb. 5, 2025
Language: Английский
Citations
5
Deleted Journal, Journal Year: 2024, Volume and Issue: 6(8)
Published: July 29, 2024
Abstract Arteriosclerosis (AS) presents a significant global health challenge, demanding innovative therapeutic strategies. This review explores the potential of nanoparticles (NPs) and mesenchymal stem cells (MSCs) as promising modalities for treating AS. NPs enable targeted drug delivery, while MSCs possess immunomodulatory regenerative capabilities. We discuss recent advances in NP-based delivery systems tailored AS treatment highlight MSCs’ roles modulating inflammation promoting vascular repair. Additionally, we examine synergistic effects combining enhanced outcomes. Furthermore, this paper provides insights into targeting endothelial cells, T-cells, macrophages, lipid levels, plaques using MSCs. It also reviews various types metal-based non-metallic utilized therapy. comprehensive overview underscores synergies between cardiovascular disease therapy, emphasizing need further research to fully realize their implications. Graphical
Language: Английский
Citations
13
Biomedical Physics & Engineering Express, Journal Year: 2024, Volume and Issue: 10(5), P. 052002 - 052002
Published: Aug. 14, 2024
Abstract Purpose . This review aims to highlight current improvements in microfluidic devices designed for digestive cancer simulation. The emphasizes the use of multicellular 3D tissue engineering models understand complicated biology tumor microenvironment (TME) and progression. purpose is develop oncology research improve patients’ lives. Methods analyzes recent on mimicking cancer. It uses tissue-engineered devices, notably organs a chip (OOC), simulate human organ function lab. Cell cultivation modern three-dimensional hydrogel platforms allows precise geometry, biological components, physiological qualities. novel methodologies, key findings, technical progress explain this field’s advances. Results study discusses advances Micro systems with are emphasized. These capture complex biochemical gradients, niche variables, dynamic cell–cell interactions (TME). reveal stomach progression by duplicating TME. Recent discoveries technology have improved our understanding gut biology, as shown review. Conclusion Microfluidic play crucial role modeling furthering research. could transform drug development treatment revealing provides complete summary suggests future field professionals. review’s major goal further medical
Language: Английский
Citations
13
Critical Reviews in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25
Published: Sept. 17, 2024
This comprehensive review delves into the advancements and challenges in biosensing, with a strong emphasis on transformative potential of CRISPR technology for early rapid detection infectious diseases. It underscores versatility CRISPR/Cas systems, highlighting their ability to detect both nucleic acids non-nucleic acid targets, seamless integration isothermal amplification techniques. The provides thorough examination latest developments CRISPR-based biosensors, detailing unique properties such as high specificity programmability, which make them particularly effective detecting disease-associated acids. While focuses due its critical role diagnosing diseases, it also explores broader applications thereby acknowledging technology's potential. Additionally, identifies existing challenges, need improved signal real-world applicability, offers future perspectives aimed at overcoming these hurdles. ultimate goal is advance development highly sensitive specific biosensors that can be used widely improving human health, point-of-care settings resource-limited environments.
Language: Английский
Citations
13
Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123120 - 123120
Published: Oct. 1, 2024
Language: Английский
Citations
8
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Dec. 12, 2024
Mortality and morbidity from cardiovascular diseases are common worldwide. In order to improve survival quality of life for this patient population, extensive efforts being made establish effective therapeutic modalities. New treatment options needed, it seems. addition treating diseases, cell therapy is one the most promising medical platforms. One approaches in area stem therapy. biology, multipotent cells pluripotent divided into two types. There evidence that could be used as a approach based on multiple lines evidence. The effectiveness therapies humans has been studied several clinical trials. spite challenges associated with therapy, appears resolving them may lead disease patients. This an approach. By mounting these biological scaffolds, their effect can enhanced.
Language: Английский
Citations
7
Analytical Methods, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review explores emerging CRISPR-microfluidic platforms enhancing precision, speed, and portability for point-of-care diagnostics. Innovations like SHINE, CARMEN, ITP, DNAiTECH, Dμchip, FAST, MAPnavi highlight their potential.
Language: Английский
Citations
0