Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 26, 2025
Abstract
The
clinical
progress
of
tumor
nucleotide
vaccines
is
limited
due
to
insufficient
recognition
and
killing
cells
with
low
antigen
expression
by
cytotoxic
T
lymphocytes
(CTL).
Here,
natural
cholesterol
analogs
are
screened
assemble
self‐adjuvant
lipid
nanoparticles
(LNPs)
for
antigens
tagging
dendritic
(DC)
activation.
First,
a
library
ginsenosides
collected,
then
according
their
anti‐tumor
immunity.
Then,
ginsenoside‐Rg3
based‐LNPs
loaded
(Rg3‐LNPs)
identified
as
the
optimal
formulation
investigating
physicochemical
biological
properties.
Finally,
Rg3‐LNPs
granulocyte‐macrophage
colony‐stimulating
factor
(GM‐CSF)
co‐loaded
into
macroporous
hydrogel
long‐term
immune
response.
could
accumulate
both
tumors
LNs.
targeted
high
glucose
transporter‐1
via
targeting
ligand
Rg3,
anchored
on
cell
surface,
thus
promoting
CTL
cells;
can
LNs
promote
DC
activation
presentation,
stimulating
Besides,
an
adjuvant,
cooperated
GM‐CSF
remodel
microenvironment,
cells.
Collectively,
this
work
highlights
importance
in
vaccine
has
great
value
immune‐escaping
tumors.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Sept. 2, 2023
Immunotherapy
has
recently
emerged
as
a
treatment
strategy
which
stimulates
the
human
immune
system
to
kill
tumor
cells.
Tumor
immunotherapy
is
based
on
editing,
enhances
antigenicity
of
cells
and
increases
tumoricidal
effect
It
also
suppresses
immunosuppressive
molecules,
activates
or
restores
function,
anti-tumor
responses,
inhibits
growth
f
cell.
This
offers
possibility
reducing
mortality
in
triple-negative
breast
cancer
(TNBC).Immunotherapy
approaches
for
TNBC
have
been
diversified
recent
years,
with
breakthroughs
this
entity.
Research
checkpoint
inhibitors
(ICIs)
made
it
possible
identify
different
molecular
subtypes
formulate
individualized
schedules.
review
highlights
unique
microenvironment
integrates
analyzes
advances
ICI
therapy.
discusses
strategies
combination
ICIs
chemotherapy,
radiation
therapy,
targeted
emerging
methods
such
nanotechnology,
ribonucleic
acid
vaccines,
gene
Currently,
numerous
ongoing
completed
clinical
trials
are
exploring
utilization
conjunction
existing
modalities
TNBC.
The
objective
these
investigations
assess
effectiveness
various
combined
determine
most
effective
regimens
patients
TNBC.This
provides
insights
into
used
overcome
drug
resistance
immunotherapy,
explores
directions
development
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 20, 2024
Triple
negative
breast
cancer
(TNBC)
featuring
high
relapses
and
metastasis
shows
limited
clinical
therapeutic
efficiency
with
chemotherapy
for
the
extremely
complex
tumor
microenvironment,
especially
angiogenesis
immunosuppression.
Combination
of
antiangiogenesis
immunotherapy
holds
promise
effective
inhibition
proliferation
invasion,
while
it
remains
challenging
specific
targeting
drug
delivery
to
tumors
metastatic
lesions.
Here,
a
multifunctional
biomimetic
liposome
loading
Gambogic
acid
(G/R-MLP)
is
developed
using
Ginsenoside
Rg3
(Rg3)
substitute
cholesterol
cell
membrane
coating,
which
designed
increase
long-circulating
action
by
low
immunogenicity
specifically
deliver
gambogic
(GA)
site
lesions
homologous
glucose
transporter
targeting.
After
G/R-MLP
accumulates
in
primary
nodules,
synergistically
enhances
antitumor
efficacy
GA,
effectively
suppressing
growth
lung
killing
cells,
inhibiting
migration
achieving
improving
immunity.
All
all,
strategy
combining
chemotherapy,
antiangiogenesis,
improves
prolonged
survival,
providing
new
perspective
treatment
TNBC.
Drug Discovery Today,
Journal Year:
2023,
Volume and Issue:
29(1), P. 103851 - 103851
Published: Dec. 12, 2023
Breast
cancer
is
the
most
common
and
malignant
tumor
among
women.
Chitosan
(CS)-based
nanoparticles
have
been
introduced
into
breast
therapy
as
a
way
to
increase
targeted
delivery
of
drugs
genes
site.
CS
nanostructures
suppress
tumorigenesis
by
enhancing
both
cargo
(drug
gene)
its
accumulation
in
cells.
The
cells
internalize
CS-based
through
endocytosis.
Moreover,
chitosan
nanocarriers
can
also
induce
phototherapy-mediated
ablation.
Smart
multifunctional
types
nanoparticles,
including
pH-,
light-
redox-responsive
be
used
improve
potential
for
removal.
In
addition,
acceleration
immunotherapy
has
achieved,
there
develop
CS-nanoparticle
hydrogels
that
tumorigenesis.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: Aug. 1, 2023
Abstract
Immune
checkpoint
inhibitors
(ICIs)
have
shown
remarkable
success
in
cancer
treatment.
However,
patients
without
sufficient
antitumor
immunity,
numerous
data
indicate
that
blocking
the
negative
signals
elicited
by
immune
checkpoints
is
ineffective.
Drugs
stimulate
activation‐related
pathways
are
emerging
as
another
route
for
improving
immunotherapy.
In
addition,
development
of
nanotechnology
presents
a
promising
platform
tissue
and
cell
type‐specific
delivery
improved
uptake
immunomodulatory
agents,
ultimately
leading
to
enhanced
immunotherapy
reduced
side
effects.
this
review,
we
summarize
discuss
latest
developments
nanoparticles
(NPs)
immuno‐oncology
therapy
with
focus
on
lipid‐based
NPs
(lipid‐NPs),
including
characteristics
advantages
various
types.
Using
agonists
targeting
stimulation
interferon
genes
(STING)
transmembrane
protein
an
exemplar,
review
potential
lipid‐NPs
augment
STING
agonist
therapy.
Furthermore,
present
recent
findings
underlying
mechanisms
how
pathway
activation
fosters
immunity
regulates
tumor
microenvironment
provide
summary
distinct
preclinical
studies
clinical
trials.
Ultimately,
conduct
critical
assessment
obstacles
future
directions
utilization
enhance
Cancer Communications,
Journal Year:
2024,
Volume and Issue:
44(3), P. 384 - 407
Published: Feb. 26, 2024
Liver
cancer
is
a
malignancy
with
high
morbidity
and
mortality
rates.
Serpin
family
E
member
2
(SERPINE2)
has
been
reported
to
play
key
role
in
the
metastasis
of
many
tumors.
In
this
study,
we
aimed
investigate
potential
mechanism
SERPINE2
liver
metastasis.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 4, 2025
The
tumor
microenvironment
(TME)
is
a
complex
and
dynamic
ecosystem
that
plays
critical
role
in
cancer
progression.
It
comprises
various
cell
types,
including
immune
cells,
stromal
cells.
Among
these,
cancer-associated
fibroblasts
(CAFs)
represent
heterogeneous
population
with
diverse
origins,
phenotypes,
functions.
Activated
CAFs
secrete
multiple
factors
promote
growth,
migration,
angiogenesis,
contribute
to
chemoresistance.
Additionally,
extracellular
matrix
(ECM)
components,
such
as
collagen,
which
form
physical
barrier
hinders
the
penetration
of
chemotherapeutic
immunotherapeutic
agents.
This
ECM
also
influences
infiltration,
impeding
their
ability
effectively
target
As
result,
modulating
activity
has
emerged
promising
strategy
enhance
efficacy
immunotherapy.
Nano-delivery
systems,
constructed
from
nanomaterials
high
targeting
specificity
biocompatibility,
offer
compelling
approach
deliver
therapeutic
agents
or
immunomodulatory
directly
CAFs.
modulation
can
alter
CAF
function,
reduce
tumor-promoting
effects,
thereby
improve
outcomes
review
provides
an
in-depth
exploration
functions,
interactions
within
TME,
particularly
context
suppression.
Furthermore,
it
discusses
potential
applications
functional
nanocarrifers
enhancing
effectiveness
immunotherapy,
highlighting
significant
progress
nanotechnology
this
area.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
167, P. 115622 - 115622
Published: Sept. 30, 2023
The
tumor
microenvironment
(TME),
the
"soil"
on
which
cells
grow,
has
an
important
role
in
regulating
proliferation
and
metastasis
of
as
well
their
response
to
treatment.
Cancer-associated
fibroblasts
(CAFs),
most
abundant
stromal
TME,
can
not
only
directly
alter
immunosuppressive
effect
TME
through
own
metabolism,
but
also
influence
aggregation
function
immune
by
secreting
a
large
number
cytokines
chemokines,
reducing
body's
surveillance
making
them
more
prone
escape.
Our
study
provides
comprehensive
review
fibroblast
chemotaxis,
malignant
transformation,
metabolic
characteristics,
interactions
with
cells.
In
addition,
current
small
molecule
drugs
targeting
CAFs
have
been
summarized,
including
both
natural
molecules
targeted
for
clinical
therapeutic
applications.
A
complete
from
perspective
is
presented,
implications
improving
efficiency
immunotherapy
fibroblasts.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 7415 - 7471
Published: July 1, 2024
Abstract:
Cancer,
as
the
foremost
challenge
among
human
diseases,
has
plagued
medical
professionals
for
many
years.
While
there
have
been
numerous
treatment
approaches
in
clinical
practice,
they
often
cause
additional
harm
to
patients.
The
emergence
of
nanotechnology
brought
new
directions
cancer
treatment,
which
can
deliver
anticancer
drugs
specifically
tumor
areas.
This
article
first
introduces
application
scenarios
nanotherapies
and
strategies
nanomedicine.
Then,
noteworthy
characteristics
exhibited
by
biopolymer
materials
were
described,
make
biopolymers
stand
out
polymeric
nanomedicine
delivery.
Next,
we
focus
on
summarizing
state-of-art
studies
five
categories
proteins
(Albumin,
Gelatin,
Silk
fibroin,
Zein,
Ferritin),
nine
varieties
polysaccharides
(Chitosan,
Starch,
Hyaluronic
acid,
Dextran,
cellulose,
Fucoidan,
Carrageenan,
Lignin,
Pectin)
liposomes
field
drug
Finally,
also
provide
a
summary
advantages
limitations
these
biopolymers,
discuss
prevailing
impediments
their
application,
detail
prospective
research
directions.
review
not
only
helps
readers
understand
current
development
status
nano
delivery
systems
based
but
is
helpful
properties
various
find
suitable
solutions
this
through
comparative
reading.
Keywords:
delivery,
nanoformulations,
polymer,
proteins,
