Lithium in Cancer Therapy: Friend or Foe?

Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1095 - 1095

Published: Feb. 8, 2023

Lithium, a trace element important for fetal health and development, is considered metal drug with well-established clinical regime, economical production process, mature storage system. Several studies have shown that lithium affects tumor development by regulating inositol monophosphate (IMPase) glycogen synthase kinase-3 (GSK-3). Lithium can also promote proliferation programmed cell death (PCD) in cells through number of new targets, such as the nuclear receptor NR4A1 Hedgehog-Gli. may increase cancer treatment efficacy while reducing side effects, suggesting it be used an adjunctive therapy. In this review, we summarize effects on progression discuss underlying mechanisms. Additionally, lithium’s limitations antitumor applications, including its narrow therapeutic window potential pro-cancer immune

Language: Английский

---

Underlying mechanisms of novel cuproptosis-related dihydrolipoamide branched-chain transacylase E2 (DBT) signature in sunitinib-resistant clear-cell renal cell carcinoma

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Renal cell carcinoma (RCC) is the predominant form of malignant kidney cancer. Sunitinib, a primary treatment for advanced, inoperable, recurrent, or metastatic RCC, has shown effectiveness in some patients but increasingly limited by drug resistance. Recently identified cuproptosis, copper-ion-dependent programmed death, holds promise combating cancer, particularly drug-resistant types. However, its treating resistant RCC remains to be determined. Exploring cuproptosis's regulatory mechanisms could enhance strategies. Our analysis data from GEO and TCGA databases showed that cuproptosis-related gene DBT markedly under expressed tissues, correlating with worse prognosis disease progression. In our study, we investigated copper CRGs ccRCC, noting substantial expression differences, advanced-stage tumors. We established connection between CRG levels patient survival, positioning as potential therapeutic targets ccRCC. cases, found distinct patterns GLS CRGs, linked experiments demonstrated increasing significantly reduces growth spread, underscoring target. This research sheds new light on role ccRCC their impact

Language: Английский

---

Identification of AURKA as a Biomarker Associated with Cuproptosis and Ferroptosis in HNSCC

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4372 - 4372

Published: April 16, 2024

Cuproptosis and ferroptosis represent copper- iron-dependent forms of cell death, respectively, both are known to play pivotal roles in head neck squamous carcinoma (HNSCC). However, few studies have explored the prognostic signatures related cuproptosis HNSCC. Our objective was construct a model based on genes associated with ferroptosis. We randomly assigned 502 HSNCC samples from The Cancer Genome Atlas (TCGA) into training testing sets. Pearson correlation analysis utilized identify cuproptosis-associated set. Cox proportional hazards (COX) regression least absolute shrinkage operator (LASSO) were employed model. performance internally validated using single-factor COX regression, multifactor Kaplan–Meier analysis, principal component (PCA), receiver operating curve (ROC) analysis. Additionally, we obtained 97 Gene Expression Omnibus (GEO) database for external validation. constructed model, 12 genes, proved be an independent predictor HNSCC prognosis. Among these increased expression aurora kinase A (AURKA) has been implicated various cancers. To further investigate, small interfering RNAs (siRNAs) knock down AURKA conducted functional experiments. results demonstrated that knockdown significantly inhibited proliferation migration cells (Cal27 CNE2). Therefore, may serve as potential biomarker

Language: Английский

---

Immunomodulatory metal-based biomaterials for cancer immunotherapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 249 - 268

Published: Sept. 12, 2024

Language: Английский

---

Prognosis and personalized treatment prediction in lung adenocarcinoma: An in silico and in vitro strategy adopting cuproptosis related lncRNA towards precision oncology

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 15, 2023

Background: There is a rapid increase in lung adenocarcinomas (LUAD), and studies suggest associations between cuproptosis the occurrence of various types tumors. However, it remains unclear whether plays role LUAD prognosis. Methods: Dataset TCGA-LUAD was treated as training cohort, while validation cohort consisted merged datasets GSE29013, GSE30219, GSE31210, GSE37745, GSE50081. Ten studied cuproptosis-related genes (CRG) were used to generated CRG clusters cluster-related differential expressed gene (CRG-DEG) clusters. The differently lncRNA that with prognosis ability CRG-DEG put into LASSO regression for signature (CRLncSig). Kaplan-Meier estimator, Cox model, receiver operating characteristic (ROC), time-dependent AUC (tAUC), principal component analysis (PCA), nomogram predictor further deployed confirm model's accuracy. We examined connections other forms regulated cell death, including apoptosis, necroptosis, pyroptosis, ferroptosis. immunotherapy demonstrated by applying eight mainstream immunoinformatic algorithms, TMB, TIDE, immune checkpoints. evaluated potential drugs high risk CRLncSig LUADs. Real-time PCR human tissues performed verify expression pattern, signature's pan-cancer's also assessed. Results: A nine-lncRNA signature, CRLncSig, built owning prognostic power applied cohort. Each confirmed differentially real world real-time PCR. correlated 2,469/3,681 (67.07%) apoptosis-related genes, 13/20 (65.00%) necroptosis-related 35/50 (70.00%) pyroptosis-related 238/380 (62.63%) ferroptosis-related genes. Immunotherapy suggested status, checkpoints, KIR2DL3, IL10, IL2, CD40LG, SELP, BTLA, CD28, linked closely our potentially suitable targets. For those high-risk patients, we found three agents, gemcitabine, daunorubicin, nobiletin. Finally, some lncRNAs play vital cancer need more attention studies. Conclusion: results this study can help determine outcome effectiveness immunotherapy, well better select targets therapeutic agents.

Language: Английский

---