Heliyon, Journal Year: 2024, Volume and Issue: 10(19), P. e38831 - e38831
Published: Oct. 1, 2024
Language: Английский
Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(7), P. 3037 - 3055
Published: Jan. 11, 2024
Language: Английский
Citations
19
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(30)
Published: March 14, 2024
Abstract Malignant pleural effusion (MPE) poses a significant challenge in local treatment, primarily attributed to its intricate tumor immune microenvironment. The immunosuppression of natural killer (NK) cells within the microenvironment, exacerbated by selenium (Se) deficiency, constitutes pivotal treatment bottleneck. Building upon prior investigations, this study delves into impact and mechanisms functionalized lentinan nanoparticles (LET‐SeNPs) on NK MPE, presenting novel strategy for lung adenocarcinoma with malignant (MPE‐LA). synergistic application LET‐SeNPs serves replenish Se levels modulate cells, augment their quantity, restore enhance functionality. Additionally, facilitate activation through TrxR1‐IL18RAP‐pSTAT3 pathway, resulting effective cancer cell eradication reduced production. Furthermore, pre‐stimulation LET‐SeNPs, combined CAR‐NK therapy, harnesses innate system, exhibiting potent anti‐tumor effect. This research introduces compelling advance clinical implementation targeted nanomaterials or lead compounds explicit targets mechanisms, thereby enhancing therapy comprehensive diagnosis MPE.
Language: Английский
Citations
17
Journal of Chromatography B, Journal Year: 2025, Volume and Issue: 1252, P. 124448 - 124448
Published: Jan. 2, 2025
Language: Английский
Citations
2
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106060 - 106060
Published: Feb. 1, 2025
Language: Английский
Citations
2
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124535 - 124535
Published: Aug. 1, 2024
The advancements in nanotechnology, pharmaceutical sciences, and healthcare are propelling the field of theranostics, which combines therapy diagnostics, to new heights; emphasizing emergence selenium nanoparticles (SeNPs) as versatile theranostic agents. This comprehensive update offers a holistic perspective on recent developments synthesis applications SeNPs, underscoring their growing importance nanotechnology healthcare. SeNPs have shown significant potential multiple domains, including antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic, wound healing, cytoprotective therapies. review highlights adaptability biocompatibility crucial for advanced disease detection, monitoring, personalized treatment. Special emphasis is placed green techniques, eco-friendly cost-effective benefits biosensing, imaging therapeutic applications. Additionally, appraisal scrutinizes progressive trends smart stimuli-responsive conferring role innovative solutions management diagnostics. Despite promising prophylactic potential, also present several challenges, particularly regarding toxicity concerns. These challenges implications clinical translation thoroughly explored, providing balanced view current state prospects
Language: Английский
Citations
15
Future Pharmacology, Journal Year: 2025, Volume and Issue: 5(1), P. 3 - 3
Published: Jan. 8, 2025
Discovered in mid-1817 by Jöns Jacob Berzelius, selenium, belonging to Group 16 of the periodic table is an essential trace element for human and animal health, due its biocompatibility bioavailability. Additionally, it known having different oxidation states, which allows interact with distinct chemical elements form various compounds. Selenium exhibits two forms, organic inorganic; latter genotoxicity. nanoparticles have been investigated as alternative mitigate toxicity this element. With antidiabetic, antiviral, chemopreventive, antimicrobial properties, SeNPs possess significant biomedical potential can be synthesized using chemical, physical, or green methods, offering new solutions combating microbial resistance other diseases. This review discusses historical discovery preparation versatility combinations synthesis, morphological characteristics, sizes, well impact SeNP applications obtained through approaches against medically relevant microorganisms, particularly those exhibiting conventional antimicrobials.
Language: Английский
Citations
1
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Abstract Designing drugs to intelligently respond different ratio of biological electron donors/receptors in cancer cells and normal is a promising strategy achieve highly effective less toxic chemotherapy. Herein by employing metal center active the selenium‐containing electrophilic drug Ru(phtpy‐NO 2 )(phenSe)Cl ( RuSe ) with strongly polarization characteristics are synthesized which can efficiently shuttle electrons from donors convert oxidative stress. The rate transfer at selenium 1.81 times higher cell environments compared environments. This results being 14.98 more lethal than cells. Experimental demonstrate that transport process carried out via radicals intermediate positively correlated properties atoms. transports bioactive generate large number superoxide anions leading DNA damage decrease mitochondrial membrane potential further activates p53 signaling pathway amplifies cell‐killing effect after transporting electrons. work provides new avenue for design efficient chemotherapeutic agents.
Language: Английский
Citations
1
Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
1
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 276 - 291
Published: May 7, 2024
Human adenovirus (HAdV) can cause severe respiratory infections in immunocompromised patients, but its clinical treatment is seriously limited by side effects of drugs such as poor efficacy, low bioavailability and nephrotoxicity. Trace element selenium (Se) has been found will affect the disease progression pneumonia, antivirus efficacy could be improved speciation optimization. Therefore, herein we performed anti-HAdV different Se that lentinan (LNT)-decorated nanoparticles (SeNPs) exhibited cytotoxicity excellent antiviral activity. Furthermore, SeNPs@LNT reduced HAdV infection-induced mitochondrial damage excessive production reactive oxygen species (ROS). It was also involved repair host cell DNA inhibition viral replication. inhibited HAdV-induced apoptosis mainly modulating p53/Bcl-2 signaling pathway. In vivo, replenished targeting infected site through circulatory system synthesis Glutathione peroxidase 1 (GPx1). More importantly, GPx1 played an antioxidant immunomodulatory role alleviating inflammatory cytokine storm pneumonia Se-deficient mice. Collectively, this study provides a with activity, demonstrate promising pharmaceutical candidate for HAdV.
Language: Английский
Citations
8
Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 40, P. 101399 - 101399
Published: Nov. 4, 2024
Language: Английский
Citations
6