Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 393 - 415
Published: Jan. 1, 2025
Language: Английский
Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)
Published: Jan. 4, 2024
Language: Английский
Citations
204
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1829 - 1829
Published: June 26, 2023
Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, well spatial structure which mimics the extracellular matrix. However, use of nanofibers achieve controlled loading release still presents many challenges, with ongoing research exploring how load drugs onto nanofiber without loss activity control in specific spatiotemporal manner. This comprehensive study systematically reviews applications recent advances related drug-laden skin-wound management. First, we introduce commonly used methods preparation, electrostatic spinning, sol-gel, molecular self-assembly, thermally induced phase separation, 3D-printing techniques. Next, summarize polymers preparation utilizing scaffolds. We then review application drug-loaded considering different stages healing acts. Finally, briefly describe stimulus-responsive schemes scaffolds, other exciting systems.
Language: Английский
Citations
72
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129999 - 129999
Published: Feb. 7, 2024
Language: Английский
Citations
45
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 210, P. 115342 - 115342
Published: May 24, 2024
Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, recognition immune system integral role in wound healing has significantly grown, instigating an approach shift towards immunological processes. Thus, this review explores process, highlighting engagement system, delving into behaviors innate adaptive cells chronic scenarios. Moreover, article investigates biomaterial-based strategies modulation elucidating how adjustment their physicochemical properties or synergistic combination with other agents drugs, proteins mesenchymal stromal can effectively modulate different cells. Finally various based on synthetic biological nanostructures, including extracellular vesicles, finely tune natural immunomodulators therapeutic nanocarriers promising biophysical properties.
Language: Английский
Citations
26
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)
Published: Jan. 31, 2024
Abstract The skin serves as the body's outermost barrier and is largest organ, providing protection not only to body but also various internal organs. Owing continuous exposure external factors, it susceptible damage that can range from simple severe, including serious types of wounds such burns or chronic wounds. Macrophages play a crucial role in entire wound‐healing process contribute significantly regeneration. Initially, M1 macrophages infiltrate phagocytose bacteria, debris, dead cells fresh As tissue repair activated, M2 are promoted, reducing inflammation facilitating restoration dermis epidermis regenerate tissue. This suggests extracellular matrix (ECM) promotes cell adhesion, proliferation, migrationand macrophage polarization. Among numerous strategies, electrospinning versatile technique for obtaining ECM‐mimicking structures with anisotropic isotropic topologies micro/nanofibers. Various electrospun biomaterials influence polarization based on their topologies. Moreover, these fibers possess high surface‐area‐to‐volume ratio, promoting effective exchange vital nutrients oxygen, which viability Micro/nanofibers diverse physical chemical properties be tailored polarize toward regeneration wound healing, depending specific requirements. review describes significance micro/nanostructures activating healing.
Language: Английский
Citations
22
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: April 25, 2024
Angiogenesis is a prominent component during the highly regulated process of wound healing. The application exogenous vascular endothelial growth factor (VEGF) has shown considerable potential in facilitating angiogenesis. However, its effectiveness often curtailed due to chronic inflammation and severe oxidative stress diabetic wounds. Herein, an inflammation-responsive hydrogel incorporating Prussian blue nanoparticles (PBNPs) designed augment angiogenic efficacy VEGF. Specifically, rapid release PBNPs from under inflammatory conditions effectively alleviates wound, therefore reprogramming immune microenvironment preserve bioactivity VEGF for enhanced In vitro vivo studies reveal that co-loaded biocompatible possesses effective anti-inflammatory properties, thereby angiogenesis accelerate healing type 2 mouse model.
Language: Английский
Citations
22
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 15, 2025
Nanotechnology has experienced significant advancements, attracting considerable attention in various biomedical applications. This innovative study synthesizes and characterizes Ge/PLA/AuNCs (gelatin/PLA/gold nanocomposites) using Syzygium cumini extract to evaluate their The UV–Visible spectroscopy results an absorption peak at 534 nm were primarily confirmed by synthesis. FTIR spectrum showed functional groups the XRD patterns crystalline shape structure of nanocomposites. FESEM HRTEM a oval with average particle size 21 nm. Ge/PLA/AuNC's remarkable antioxidant activity, as evidenced DPPH (70.84 ± 1.64%), ABTS activity (86.17 1.96%), reducing power (78.42 1.48%) concentration 100 μg/mL was observed. zone inhibition against Staphylococcus aureus (19.45 0.89 mm) Echericia coli (20.83 0.97 revealed excellent antibacterial Ge/PLA/AuNCs. anti-diabetic supported α-amylase (82.56 1.49%) α-glucosidase (80.27 1.57%). anti-Alzheimer AChE (76.37 1.18%) BChE (85.94 1.38%) enzymes. In vivo studies zebrafish embryos that have biocompatibility nontoxicity. SH-SY5Y cell line demonstrated improved viability (95.27 1.62%) enhanced neuronal growth following treatment. conclusion, present highlights cost-effective non-toxic properties Furthermore, it presents attractive promising approach for future
Language: Английский
Citations
2
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121923 - 121923
Published: Feb. 6, 2024
Language: Английский
Citations
11
Giant, Journal Year: 2024, Volume and Issue: 18, P. 100251 - 100251
Published: March 6, 2024
The treatment of diabetic wounds is a major challenge faced by the medical system, and there growing interest in developing innovative therapies to accelerate wound healing. Regenerative medicine with cells has shown promising potential skin repair, regenerative properties primarily attributed paracrine effects secreted products, including exosomes. Compared cell-based approaches, using exosomes as cell-free therapy for chronic several advantages. Exosomes can regulate intercellular communication releasing their contents, mRNA, miRNA, lipids, proteins, which further promote are well explored biomedical application owing advantages such biocompatibility low immunogenicity. However, common method exosome administration through injection, but due rapid clearance rate body, maintaining necessary therapeutic concentration around challenging. Therefore, it develop new biocompatible scaffold carrier extracellular vesicles, allowing them sustain at non-healing sites continuously Engineered kinds modified internal treated molecules, surface decoration or delivered engineered platform. In addition, some researchers have processed exosomes, known decoration, delivery platforms. regular greater promoting this review, we summarize molecular mechanisms from different sources varying modifications Advantages limitations repair were also discussed. Finally, highlight challenges future development directions translating our knowledge into clinical practice.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2938 - 2938
Published: March 2, 2024
Poly(propylene carbonate) (PPC) is an emerging “carbon fixation” polymer that holds the potential to become a “biomaterial of choice” in healthcare owing its good biocompatibility, tunable biodegradability and safe degradation products. However, commercialization wide application PPC as biomedical material are still hindered by narrow processing temperature range, poor mechanical properties hydrophobic nature. Over recent decades, several physical, chemical biological modifications have been achieved introducing biocompatible polymers, inorganic ions or small molecules, which can endow with better cytocompatibility desirable biodegradability, thus enable various applications. Indeed, variety PPC-based degradable materials used medical applications including masks, surgical gowns, drug carriers, wound dressings, implants scaffolds. In this review, molecular structure, catalysts for synthesis, discussed. Recent biomaterials highlighted summarized.
Language: Английский
Citations
10