Catalysts,
Journal Year:
2024,
Volume and Issue:
14(6), P. 371 - 371
Published: June 10, 2024
Chitin
and
chitosan,
abundant
biopolymers
derived
from
the
shells
of
crustaceans
cell
walls
fungi,
have
garnered
considerable
attention
in
pharmaceutical
circles
due
to
their
biocompatibility,
biodegradability,
versatile
properties.
Deep
eutectic
solvents
(DESs),
emerging
green
composed
mixtures
hydrogen
bond
acceptors
donors,
offer
promising
avenues
for
enhancing
solubility
functionality
chitin
chitosan
formulations.
This
review
delves
into
potential
utilizing
DESs
as
highlighting
efficiency
dissolving
these
polymers,
which
facilitates
production
novel
drug
delivery
systems,
wound
dressings,
tissue
engineering
scaffolds,
antimicrobial
agents.
The
distinctive
physicochemical
properties
DESs,
including
low
toxicity,
volatility,
adaptable
solvation
power,
enable
customization
chitosan-based
materials
meet
specific
requirements.
Moreover,
environmentally
friendly
nature
aligns
with
growing
demand
sustainable
eco-friendly
processes
manufacturing.
revision
underscores
recent
advances
illustrating
role
evolving
applications
laying
groundwork
development
innovative
systems
biomedical
enhanced
efficacy
safety
profiles.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: May 28, 2024
The
repair
of
irregular
bone
tissue
suffers
severe
clinical
problems
due
to
the
scarcity
an
appropriate
therapeutic
carrier
that
can
match
dynamic
and
complex
damage.
Fortunately,
stimuli-responsive
in
situ
hydrogel
systems
are
triggered
by
a
special
microenvironment
could
be
ideal
method
regenerating
because
injectability,
gelatin,
spatiotemporally
tunable
drug
release.
Herein,
we
introduce
two
main
stimulus-response
approaches,
exogenous
endogenous,
forming
hydrogels
engineering.
First,
summarize
specific
distinct
responses
extensive
range
external
stimuli
(e.g.,
ultraviolet,
near-infrared,
ultrasound,
etc.)
form
created
from
biocompatible
materials
modified
various
functional
groups
or
hybrid
nanoparticles.
Furthermore,
“smart”
hydrogels,
which
respond
endogenous
physiological
environmental
temperature,
pH,
enzyme,
etc.),
achieve
gelation
one
injection
vivo
without
additional
intervention.
Moreover,
mild
chemistry
response-mediated
also
offer
fascinating
prospects
engineering,
such
as
Diels–Alder,
Michael
addition,
thiol-Michael
Schiff
reactions,
etc.
recent
developments
challenges
smart
their
application
administration
engineering
discussed
this
review.
It
is
anticipated
advanced
strategies
innovative
ideas
will
exploited
field
increase
quality
life
for
patients
with
