Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 18, 2024
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disorder
characterized
by
painful
swelling
and
inflammation,
arising
from
the
immune
system
attacking
on
healthy
cells.
However,
arthritic
sites
often
experience
increased
lymph
flow,
hastening
drug
clearance
potentially
reducing
treatment
effectiveness.
To
address
this
challenge,
in
situ
size
amplification
has
been
proposed
to
reduce
lymphatic
thereby
enhance
therapy.
This
developed
based
a
conjugate
of
dexamethasone
(Dex)
polysialic
acid
(PSA),
linked
via
acid-sensitive
linker,
supplemented
with
bis-5-hydroxytryptamine
(Bis-5HT)
PSA
backbone.
Under
physiological
conditions,
autonomously
assembles
into
stable
nanoparticles
(PD5NPs),
facilitating
prolonged
circulation
targeted
delivery
inflamed
joints.
Upon
arrival
at
joints,
Bis-5HT
reacts
elevated
myeloperoxidase
(MPO)
levels
oxidative
stress,
prompting
particle
aggregation
in-situ
amplification.
nanocarrier
effectively
reduces
serves
as
reservoirs
for
sustained
Dex
release
acidic
pH
environments
within
sites,
thus
continuously
alleviating
RA
symptoms.
Moreover,
investigation
underlying
mechanism
elucidates
how
influences
transportation
PD5NPs
joints
vessels.
Our
study
offers
valuable
insights
optimizing
nanomedicine
performance
vivo
augmenting
therapeutic
efficacy.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: April 15, 2025
The
lymphatic
system
plays
a
critical
role
in
maintaining
fluid
balance
and
immune
regulation.
Lymphedema,
other
disorders,
highlight
the
need
for
advanced
therapeutic
approaches,
including
tissue
engineering.
This
review
examines
latest
developments
artificial
engineering,
focusing
on
scaffold
materials,
lymphangiogenic
factors,
regenerative
strategies
to
replicate
intricacy
of
vessels
nodes.
We
conducted
thorough
literature
current
practices
applications
Findings
show
that
biomaterials
such
as
hydrogels,
decellularized
matrices,
synthetic
polymers
provide
effective
scaffolds
endothelial
cell
proliferation
lymphangiogenesis.
Advances
growth
factor
delivery
stem-cell
based
therapies
have
further
enhanced
viability
engineered
tissues.
Despite
promising
progress,
challenges
achieving
functional
replication
structures
clinical
translation
research
remain.
Ongoing
must
address
biocompatibility,
optimized
targeting,
scalable
production
advance
options
disorders.
underscores
potential
transformative
patient
outcomes
through
innovative
bioengineering
solutions.
Coatings,
Journal Year:
2023,
Volume and Issue:
13(11), P. 1830 - 1830
Published: Oct. 25, 2023
This
review
discusses
relevant
topics
concerning
the
understanding
of
characterization
antimicrobial
coatings
due
to
powerful
nanoparticles
in
their
composition.
These
are
utilized
surface
modification
yarns
and
materials
designed
for
use
medical
dental
applications.
Various
physical
chemical
methods
employed
create
these
coatings,
ensuring
development
efficient,
homogeneous,
uniform
layers
on
diverse
surfaces
materials.
The
primary
objective
is
confer
and/or
antiviral
properties
upon
For
be
effective,
they
must
incorporate
active
compounds
that
can
combat
a
wide
array
microorganisms,
including
those
have
developed
resistance
antibiotics.
Examples
such
include
metallic
as
silver,
copper,
gold,
well
metal
oxides
zinc,
titanium,
aluminum.
Upon
application
materials,
extensive
testing
procedures
undertaken,
which
will
thoroughly
detailed
this
review.
It
crucial
emphasize
absence
proper
could
lead
standards,
norms,
or
necessary
safeguard
human
health
environment.
Despite
widespread
field,
concerns
been
raised
regarding
potential
toxicity
living
organisms.
Consequently,
paper
provides
comprehensive
overview
current
state-of-the-art
methodologies
characterizing
specifically
focusing
with
varying
roughness
structures.
Additionally,
it
outlines
issues
associated
accumulation
within
body.
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
19(1), P. 59 - 77
Published: Jan. 1, 2024
Sentinel
lymph
node
(SLN)
detection
and
biopsy
is
a
critical
staging
component
for
several
cancers.
Apart
from
established
methods
using
dyes
or
radiolabeled
colloids,
newer
techniques
are
emerging,
like
near-infrared
fluorescent
compounds,
targeted
molecular
radiopharmaceuticals
magnetic
nano-tracers.
In
the
overview
section
of
this
review,
we
categorize
SLN
tracers
based
on
their
principle
use.
We
discuss
merits
existing
provide
glimpse
in-development
formulations.
A
subsequent
clinical
explores
expanded
role
in
management
various
cancers,
citing
current
medical
guidelines
leading
conclusions
long-term
trials.
The
concluding
tries
to
perspective
promising
developments
work
required
bring
them
fruition.
RSC Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
1(1), P. 57 - 67
Published: Jan. 1, 2024
The
overall
results
presented
in
this
work
indicate
the
potential
use
of
ICG-loaded
PEO–PPO
PMs
as
image
probe
agents
to
be
employed
image-guided
surgery,
sentinel
lymph
node
biopsy
and
breast
cancer
diagnostic
imaging.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(29)
Published: Oct. 14, 2024
Abstract
Precise
theranostics
of
tumors
is
intricately
linked
to
the
early
detection
and
monitoring
lymph
nodes
(LN)
metastases,
making
targeted
localization
LNs
essential
for
tumor
identification.
However,
designing
LN‐targeting
probes
remains
a
significant
challenge
due
issues
such
as
lymphatic
uptake,
biocompatibility,
fluorescence
stability.
To
address
these
challenges,
near‐infrared
II
(NIR‐II)
are
developed
through
meticulous
analysis
LN
physiological
structure
passive
targeting
strategy
therapy.
An
LPP‐QDs‐IR‐820
nanocomposite
(NCs)
engineered,
comprising
IR‐820
molecules
ultrabright
PbS@CdS
quantum
dots
(QDs),
which
encapsulated
within
liposome‐SH‐mPEG
2000
polymer
matrix.
These
NCs
demonstrates
remarkable
enrichment,
facilitating
real‐time
tracking
via
electrostatic
repulsion
extracellular
matrix
effects.
Importantly,
exhibit
negligible
in
vivo
toxicity
high
biocompatibility.
The
intense
NIR‐II
emissions
QDs
confer
upon
yield
(6%).
cervical
their
deep
microvessels
clearly
observed
imaging.
Moreover,
photothermal
properties
enable
achieve
conversion
efficiency
36.56%,
leading
effective
therapy
mice.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(9), P. 5752 - 5763
Published: Aug. 23, 2024
Although
nanoparticle-based
lymphatic
drug
delivery
systems
promise
better
treatment
of
cancer,
infectious
disease,
and
immune
their
clinical
translations
are
limited
by
low
efficiencies
unclear
transport
mechanisms.
Here,
we
employed
a
three-dimensional
(3D)
lymphatics-on-a-chip
featuring
an
engineered
vessel
(LV)
capable
draining
interstitial
fluids
including
nanoparticles.
We
tested
drainage
different
sizes
(30,
50,
70
nm)
PLGA-b-PEG
nanoparticles
(NPs)
using
the
device.
In
this
study,
discovered
that
smaller
NPs
(30
50
transported
faster
than
larger
(70
through
space,
as
expected,
but
were
captured
endothelial
cells
(LECs)
accumulated
within
cytosol,
delaying
NP
into
lumen,
which
was
not
observed
in
NPs.
To
examine
mechanisms
size-dependent
transports,
four
inhibitors,
dynasore,
nystatin,
amiloride,
adrenomedullin,
to
selectively
block
dynamin-,
caveolin-,
macropinocytosis-mediated
endocytosis-,
cell
junction-mediated
paracellular
transport.
Inhibiting
dynamin
dynasore
enhanced
minimizing
cytosolic
accumulation,
showed
no
effect
on
Interestingly,
inhibition
caveolin
nystatin
decreased
without
affecting
transport,
indicating
distinct
endocytosis
used
Macropinocytosis
amiloride
did
change
all
NPs;
however,
adrenomedullin
blocked
sizes.
further
revealed
Rab7-positive
late-stage
endosomes
delay
drainage,
reversed
inhibition,
suggesting
Rab7
is
potential
target
enhance
Together,
our
3D
model
unveils
delivery.
Nano Convergence,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Dec. 11, 2024
The
lymphatic
system
plays
a
crucial
role
in
maintaining
physiological
homeostasis
and
regulating
immune
responses.
Traditional
imaging
modalities
such
as
magnetic
resonance
imaging,
computerized
tomography,
positron
emission
tomography
have
been
widely
used
to
diagnose
disorders
the
system,
including
lymphedema,
lymphangioma,
metastasis,
Castleman
disease.
Nano-fluorescence
technology
has
distinct
advantages-including
naked-eye
visibility,
operational
simplicity,
portability
of
laser,
real-time
visibility-and
serves
an
innovative
alternative
traditional
techniques.
This
review
explores
recent
advancements
nano-fluorescence
aimed
at
enhancing
resolution
structure,
function,
immunity.
After
delineating
fundamental
characteristics
systems,
it
elaborates
on
development
various
systems
(including
nanoparticles
incorporating
fluorescent
dyes
those
with
intrinsic
fluorescence)
while
addressing
key
challenges
photobleaching,
limited
tissue
penetration,
biocompatibility,
signal
interference
from
biomolecules.
Furthermore,
this
highlights
clinical
applications
its
potential
integration
into
standard
diagnostic
protocols.
Ongoing
nanoparticle
underscore
revolutionize
diagnosis
treatment
