ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(37), P. 48880 - 48894
Published: Sept. 3, 2024
Myocardial
infarction
(MI)
is
a
serious
cardiovascular
disease
with
high
morbidity
and
mortality
rates,
posing
significant
threat
to
patient's
health
quality
of
life.
Following
MI,
the
damaged
myocardial
tissue
typically
not
fully
repaired,
leading
permanent
impairment
function.
While
traditional
treatments
can
alleviate
symptoms
reduce
pain,
their
ability
repair
heart
muscle
limited.
Functionalized
hydrogels,
broad
category
materials
diverse
functionalities,
enhance
properties
hydrogels
cater
needs
engineering,
drug
delivery,
medical
dressings,
other
applications.
Recently,
functionalized
have
emerged
as
promising
new
therapeutic
approach
for
treatment
MI.
possess
outstanding
biocompatibility,
customizable
mechanical
properties,
drug-release
capabilities.
These
enable
them
offer
scaffold
support,
release,
regeneration
promotion,
making
treating
This
paper
aims
evaluate
advancements
delivery
methods
while
also
discussing
potential
challenges
they
may
pose
future
clinical
use.
Biomaterials Research,
Journal Year:
2024,
Volume and Issue:
28
Published: Jan. 1, 2024
The
improvement
of
the
myocardial
microenvironment
largely
determines
prognosis
infarction
(MI).
After
MI,
early
removal
excessive
reactive
oxygen
species
(ROS)
in
can
alleviate
oxidative
stress
injury
and
promote
M2
phenotype
polarization
macrophages,
which
is
important
for
advocating
repair.
In
this
study,
we
combined
traditional
natural
hydrogel
materials
chitosan
(CS)
gelatin
(Gel)
to
encapsulate
polydopamine-modified
black
phosphorus
nanosheets
(BP@PDA).
We
designed
an
injectable
composite
gel
(CS–Gel–BP@PDA)
with
a
time-released
ability
achieve
situ
sustained-release
BP@PDA
area
MI.
Utilizing
inflammation
inhibition
CS-Gel
itself
high
activity
ROS,
continuous
infarct
repair
were
achieved.
studies
vivo
revealed
that,
compared
saline
group,
CS-Gel-BP@PDA
group
had
alleviated
fibrosis
size
importantly
improved
cardiac
function.
Immunofluorescence
results
showed
that
ROS
level
inflammatory
response
CS–Gel–BP@PDA
decreased.
conclusion,
our
study
demonstrated
ability,
antioxidative
macrophage
modulation
novel
CS-Gel-BP@PDA,
provides
inspiration
therapeutic
modalities
Acta Materia Medica,
Journal Year:
2025,
Volume and Issue:
4(1)
Published: Jan. 1, 2025
Cardiovascular
diseases
(CVDs)
pose
a
significant
threat
to
human
health
due
the
high
mortality
and
morbidity
rates.
Traditional
drugs
often
have
limited
efficacy
inherent
constraints,
such
as
low
bioavailability
notable
side
effects.
As
highly
regarded
therapeutic
strategy,
nanotechnology
offers
new
perspectives
means
for
treating
CVDs.
Nanozyme-based
targeted
specifically
address
biological
processes
in
areas
affected
by
CVDs,
thereby
achieving
precise
treatment.
Compared
traditional
drugs,
nanozymes
offer
advantages,
efficiency,
specificity,
controllability,
fewer
effects,
showing
great
This
paper
first
explores
design
strategies
mechanisms
of
nanozyme-based
therapy,
then
introduces
its
application
key
ischemic
stroke,
myocardial
infarction,
coronary
heart
disease.
Finally,
discusses
challenges
introducing
into
clinical
applications
future
development
prospects
treatment
Biomedical
materials
are
of
great
significance
for
preventing
and
treating
major
diseases
protecting
human
health.
At
present,
more
stringent
requirements
have
been
put
forward
the
preparation
methods
dimension
control
biomedical
based
on
urgent
demand
high-performance
materials,
especially
existence
various
physiological
size
thresholds
in
vitro/in
vivo.
Microfluidic
platforms
break
limitations
traditional
micro-/nanomaterial
synthesis,
which
provide
a
miniaturized
highly
controlled
environment
size-dependent
biomaterials.
In
this
review,
basic
conceptions
technical
characteristics
microfluidics
first
described.
Then
syntheses
with
different
dimensions
(0D,
1D,
2D,
3D)
driven
by
systematically
summarized.
Meanwhile,
applications
microfluidics-driven
including
diagnosis,
anti-inflammatory,
drug
delivery,
antibacterial,
disease
therapy,
discussed.
Furthermore,
challenges
developments
research
field
further
proposed.
This
work
is
expected
to
facilitate
convergence
between
bioscience
engineering
communities
continue
contribute
emerging
field.
Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: July 2, 2024
Abstract
Cardiovascular
disease
(CVD)
remains
the
predominant
cause
of
mortality
and
disability
worldwide.
Against
this
backdrop,
finding
effective
drugs
for
pharmacological
treatment
CVD
has
become
one
most
urgent
challenging
issues
in
medical
research.
Garlic
(
Allium
sativum
L.)
is
oldest
plants
world-renowned
its
dietary
medicinal
values.
Allicin
diallyl
thiosulfinate
)
primary
natural
active
ingredients
garlic,
which
been
proven
to
have
powerful
cardioprotective
effects
mediate
various
pathological
processes
related
CVD,
such
as
inflammatory
factor
secretion,
myocardial
cell
apoptosis,
oxidative
stress,
more.
Therefore,
allicin
holds
a
promising
application
prospect
CVD.
This
review
summarized
biological
functions
potential
mechanisms
including
antioxidation,
anti-inflammation,
anti-apoptosis
effects.
Reckoning
with
these,
we
delved
into
recent
studies
on
allicin’s
concerning
CVDs,
atherosclerosis,
hypertension,
infarction,
arrhythmia,
cardiac
hypertrophy,
heart
failure,
cardiotoxicity.
Further,
considering
tremendous
advancement
nanomedicine,
nanotechnology-based
drug
delivery
systems
show
promise
addressing
limitations
clinical
applications,
improving
solubility,
stability,
bioavailability.
Through
review,
hope
provide
reference
further
research
cardioprotection
development.
Graphical
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 25, 2024
Myocardial
infarction
(MI)
causes
extensive
structural
and
functional
damage
to
the
cardiac
tissue
due
significant
loss
of
cardiomyocytes.
Early
reperfusion
is
standard
treatment
strategy
for
acute
MI,
but
it
associated
with
adverse
effects.
Additionally,
current
therapies
alleviate
pathological
changes
post-MI
are
not
effective.
Subsequent
remodeling
damaged
myocardium
often
results
in
heart
failure.
Oral
drugs
aimed
at
reducing
myocardial
require
repeated
administration
high
doses
maintain
therapeutic
levels.
This
compromises
efficacy
patient
adherence
may
cause
effects,
such
as
hypotension
liver
and/or
kidney
dysfunction.
Hydrogels
have
emerged
an
effective
delivery
platform
orthotopic
MI
their
water
content
excellent
compatibility.
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
24(7)
Published: April 5, 2024
Biomaterials
denoting
self-healing
and
versatile
structural
integrity
are
highly
curious
in
the
biomedicine
segment.
The
injectable
and/or
printable
3D
printing
technology
is
explored
a
few
decades
back,
which
can
alter
their
dimensions
temporarily
under
shear
stress,
showing
potential
healing/recovery
tendency
with
patient-specific
intervention
toward
development
of
personalized
medicine.
Thus,
hydrogels
(IHs)
stunning
developing
paradigm
for
tissue
regeneration.
This
review
comprises
designing
IHs,
rheological
characterization
stability,
several
benchmark
consequences
translation
into
regeneration
specific
types,
applications
IHs
biomedical
such
as
anticancer
immunomodulation,
wound
healing
tissue/bone
regeneration,
antimicrobial
potentials,
drugs,
gene
vaccine
delivery,
ocular
printing,
cosmeceuticals,
photothermal
therapy
well
other
allied
avenues
like
agriculture,
aerospace,
electronic/electrical
industries,
coating
approaches,
patents
associated
therapeutic/nontherapeutic
avenues,
numerous
futuristic
challenges
solutions.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Dec. 18, 2024
The
excessive
release
of
reactive
oxygen
species
(ROS)
after
myocardial
infarction
(MI)
disrupts
the
natural
healing
process,
leading
to
cardiac
fibrosis
and
compromising
patient
prognosis.
However,
clinical
application
many
antioxidant
drugs
for
MI
treatment
is
hindered
by
their
poor
efficacy
inability
specifically
target
heart.
Here
we
developed
a
tannic
acid-modified
MnO2
nanozyme
(named
MnO2@TA),
which
can
achieve
targeting
inhibit
post-MI
enhance
function.
Specifically,
MnO2@TA
nanozyme,
endowed
with
superoxide
dismutase
(SOD)
catalase
(CAT)
activities,
effectively
scavenges
ROS,
suppressing
fibroblast
activation
mitigating
without
affecting
repair.
Notably,
incorporation
TA
improves
nanozyme's
affinity
elastin
collagen-rich
extracellular
matrix
in
tissues,
significantly
increasing
its
retention
uptake
within
heart
thereby
enhancing
anti-fibrotic
efficacy.
In
murine
model,
demonstrates
remarkable
protection
safety,
improving
function
while
attenuating
fibrosis.
This
study
presents
valuable
reference
research
aimed
at
inhibiting
advancing
treatments.
MedComm – Biomaterials and Applications,
Journal Year:
2025,
Volume and Issue:
4(1)
Published: March 1, 2025
ABSTRACT
Cardiac
tissue
engineering
presents
a
viable
strategy
for
the
targeted
therapy
of
myocardial
infarction
(MI),
overcoming
limitations
existing
therapies
in
cardiac
repair
and
regeneration.
This
review
explores
potential
stimuli‐responsive
biomaterials
that
engage
with
environment
by
reacting
to
various
environmental
stimuli
including
pH,
temperature,
enzymes,
ultrasound,
reactive
oxygen
species.
These
materials
enable
precise
drug
delivery,
modulate
cellular
responses,
enhance
Biomaterials
such
as
hydrogels,
polymers,
chitosan,
collagen,
alginate
improve
accuracy
effectiveness
localized
delivery
drugs,
stem
cells,
growth
factors,
thus
improving
precision
efficacy
treatments.
The
looks
at
ability
these
mimic
complex
biochemical
mechanical
cues
healthy
myocardium.
challenges
prospects
clinical
applications
are
discussed,
highlighting
their
transformative
while
outcomes
patients
MI.
