Metal-based nanomaterials with enzyme-like characteristics for bacterial rapid detection and control

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215799 - 215799

Published: April 1, 2024

Language: Английский

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Recent Progress and Prospect of Metal–Organic Framework-Based Nanozymes in Biomedical Application

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(3), P. 244 - 244

Published: Jan. 23, 2024

A nanozyme is a nanoscale material having enzyme-like properties. It exhibits several superior properties, including low preparation cost, robust catalytic activity, and long-term storage at ambient temperatures. Moreover, high stability enables repetitive use in multiple reactions. Hence, it considered potential replacement for natural enzymes. Enormous research interest nanozymes the past two decades has made imperative to look better enzyme-mimicking materials biomedical applications. Given this, on metal–organic frameworks (MOFs) as gained momentum. MOFs are advanced hybrid of inorganic metal ions organic ligands. Their distinct composition, adaptable pore size, structural diversity, ease tunability physicochemical properties enable mimic activities act promising candidates. This review aims discuss recent advances development MOF-based (MOF-NZs) highlight their applications field biomedicine. Firstly, different enzyme-mimetic exhibited by discussed, insights given into various strategies achieve them. Modification functionalization deliberated obtain MOF-NZs with enhanced activity. Subsequently, biosensing therapeutics domain discussed. Finally, concluded giving challenges encountered possible directions overcome them future. With this review, we aim encourage consolidated efforts across enzyme engineering, nanotechnology, science, biomedicine disciplines inspire exciting innovations emerging yet field.

Language: Английский

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Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Language: Английский

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Nanozyme-reinforced hydrogel coatings for prevention of catheter-associated urinary tract infection

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102271 - 102271

Published: April 21, 2024

Language: Английский

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Advancements in nanozymes research for the management of chronic wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299

Published: Nov. 1, 2024

Language: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553

Published: Feb. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Language: Английский

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Research Progress on Antibacterial Applications of Bioactive Materials in Wound Infections: Design, Challenges, and Prospects

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Bacterial wound infections pose a significant threat to global health, exacerbated by the increase in multidrug-resistant bacteria (MDRB) and formation of elastic biofilms. This review explores transformative potential bioactive materials addressing these challenges, focusing on their design, mechanisms action, therapeutic effects. In vivo, are designed respond unique bacterial microenvironment (BME), utilizing enzyme activity, controlled gas release, surface functionalization, immune regulation combat infections. vitro, this provides comprehensive overview latest advances rational design materials, emphasizing synergistic integration structural modifications (such as size morphology) with external physical stimuli light, sound, electricity, magnetism, force) enhance antibacterial performance. Finally, outstanding challenges prospects rapidly evolving field discussed.

Language: Английский

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Stimuli‐Responsive New Horizons for Biomedical Applications: Metal–Organic Framework‐Based Nanozymes

Small Structures, Journal Year: 2024, Volume and Issue: 5(7)

Published: April 26, 2024

Nanozymes, nanomaterials exhibiting enzyme‐mimicking activities, have gained considerable interest in biomedicine due to their stability, adjustability, and cost‐efficiency. Among these, metal–organic framework (MOF)‐based nanozymes distinguish themselves by distinct structure customizable characteristics. Researchers explored MOF‐based as a platform for developing stimuli‐responsive behaviors. This work first presents the categorization of nanozymes, which are designed mimic catalytic functions oxidases, peroxidases, catalase, superoxide dismutase, hydrolases, multifunctional enzymes. Crafting includes customizing reactions particular stimuli, including pH, temperature, light, or biomolecular triggers, ensuring enhanced specificity potency performance amid environmental changes. Moreover, these exhibit immense potential biomedical applications, playing crucial roles therapeutic interventions like cancer therapy tissue regeneration. Finally, article delves into future opportunities challenges within emerging research frontiers. These offer novel avenues advanced strategies, providing prospects innovative applications.

Language: Английский

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Nanozymes meet hydrogels: Fabrication, progressive applications, and perspectives

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 338, P. 103404 - 103404

Published: Jan. 23, 2025

Language: Английский

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Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101522 - 101522

Published: Jan. 25, 2025

Language: Английский

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