Redox-manipulating nanocarriers for anticancer drug delivery: a systematic review

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 28, 2024

Language: Английский

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Protective effect of carbon dots as antioxidants on intestinal inflammation by regulating oxidative stress and gut microbiota in nematodes and mouse models

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111871 - 111871

Published: March 16, 2024

Language: Английский

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Probiotic nanocomposite materials with excellent resistance, inflammatory targeting, and multiple efficacies for enhanced treatment of colitis in mice

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 8, 2025

The occurrence of inflammatory bowel disease (IBD) is relevant to impaired intestinal mucosal barrier and disordered gut microbiota, subsequently leading excessive production reactive oxygen species (ROS) elevated levels factors. Traditional therapies focus on inhibiting inflammation, but the vast majority involve non-targeted systemic administration, whose long-term use may result in potential side effects. Oral microbial therapy has exhibited great application prospects currently IBD treatment; however, its progress been slowed by issues with deficient bioavailability, poor targeting colitis, low therapeutic efficacy. Consequently, it exceedingly desirable develop a strategy which probiotics can be endowed additional anti-inflammatory antioxidant properties, as well enhanced inflamed intestine. Herein, we present an innovative for encapsulating probiotic Bacillus coagulans spores rosmarinic acid (RA) silk fibroin (SF). Probiotics spore morphology possessed strong gastrointestinal environmental resistance; RA alleviated oxidative damage scavenging ROS inhibited responses; SF assisted release colonize We demonstrated efficacy composite materials colitis mouse model, significantly series symptoms, cytokine storms, restored balance downregulated inflammation-related signaling pathways. are optimistic that utilization nanocoating modify will open up novel avenues future IBD.

Language: Английский

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Recent advances in the treatment of gout with NLRP3 inflammasome inhibitors

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 112, P. 117874 - 117874

Published: Aug. 16, 2024

Language: Английский

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Orally biomimetic metal-phenolic nanozyme with quadruple safeguards for intestinal homeostasis to ameliorate ulcerative colitis

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 6, 2024

Ulcerative colitis (UC) is defined by persistent inflammatory processes within the gastrointestinal tract of uncertain etiology. Current therapeutic approaches are limited in their ability to address oxidative stress, inflammation, barrier function restoration, and modulation gut microbiota a coordinated manner maintain intestinal homeostasis.

Language: Английский

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Targeting programmed cell death in inflammatory bowel disease through natural products: New insights from molecular mechanisms to targeted therapies

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 5, 2024

Abstract Inflammatory bowel disease (IBD) is an autoimmune disorder primarily characterized by intestinal inflammation and recurrent ulceration, leading to a compromised barrier inflammatory infiltration. This disorder's pathogenesis mainly attributed extensive damage or death of epithelial cells, along with abnormal activation impaired regulation immune cells the release various factors, which contribute environment in intestines. Thus, maintaining homeostasis hinges on balancing survival functionality cell types. Programmed (PCD) pathways, including apoptosis, pyroptosis, autophagy, ferroptosis, necroptosis, neutrophil extracellular traps, are integral IBD mediating cells. Natural products derived from plants, fruits, vegetables have shown potential regulating PCD, offering preventive therapeutic avenues for IBD. article reviews role natural treatment focusing targeting PCD opening new clinical management.

Language: Английский

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RNF128 deficiency in macrophages promotes colonic inflammation by suppressing the autophagic degradation of S100A8

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 15, 2025

Abstract Macrophages play important roles in maintaining intestinal homeostasis and the pathogenesis of inflammatory bowel diseases (IBDs). However, underlying mechanisms that govern macrophage-mediated inflammation are still largely unknown. In this study, we report RNF128 is downregulated proinflammatory macrophages. deficiency leads to elevated levels effector cytokines vitro accelerates progression IBD mouse models. Bone marrow transplantation experiments revealed bone cells contributes worsening DSS-induced colitis. Mechanistically, interacts with destabilizes S100A8 by promoting its autophagic degradation, which mediated cargo receptor Tollip. Moreover, administration an neutralizing antibody mitigated development colitis improved survival DSS-treated Rnf128 −/− mice. Overall, our study underscores anti-inflammatory role macrophages during highlights potential targeting RNF128-Tollip-S100A8 axis attenuate for treatment

Language: Английский

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Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.

Language: Английский

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Immunotherapy strategy for treating inflammatory bowel disease based on a nanozyme/total glucosides of paeony hybrid materials

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 1, 2025

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory condition that has long plagued patients. Herein, an innovative oral treatment strategy for IBD proposed, which utilizes calcium alginate hydrogel as carrier to deliver Co3O4 nanocages loaded with total glucosides of paeony (TGP) into the body. This design ingeniously exploits protective properties outer layer ensure enzyme not prematurely degraded when passing through acidic gastric juice. However, upon reaching inflamed intestinal site, overexpressed H2O2 there mixes specific solution, causing degrade and release Co3O4@TGP. These negatively charged nanozymes can precisely recognize accumulate in colonic tissue, achieving targeted therapy their unique charge characteristics. More importantly, itself possesses excellent catalytic activity, effectively consuming excess at site inflammation degrading 10 nm small particles process, while simultaneously releasing TGP. Together, they exert dual effects scavenging reactive oxygen species (ROS) anti-inflammation. Its therapeutic mechanism involves fine regulation expression key proteins such TLR7, MYD88, GAPDH, well effective inhibition NF-κB signaling pathway. series actions only reduces various pro-inflammatory cytokines (such TNF-α, IL-18, IL-1β, IL-6, HMGB1) but also promotes production anti-inflammatory cytokine IL-10, thereby maintaining integrity barrier. research achievement opens up novel path colitis.

Language: Английский

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Tumor‐Associated Macrophages: Key Players in the Non‐Small Cell Lung Cancer Tumor Microenvironment

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(3)

Published: Feb. 1, 2025

ABSTRACT Background Lung cancer is among the most common and deadliest malignant tumors worldwide. It often detected at late stages, resulting in unfavorable outcomes, with tumor cell heterogeneity medication resistance. Tumor‐associated macrophages are key cells contributing to progression. They categorized into two primary phenotypes: Proinflammatory (M1) anti‐inflammatory (M2) which involved onset progression of NSCLC. The role cytokines secreted by lung described, effects various substances such as RNA or protein on differentiation polarization phenotypes highlighted characterize impact immune state therapeutic effect treatments patient prognosis. Researchers have primarily aimed investigate innovative carriers strategies based modify microenvironment. Objectives These approaches integrated other treatments, particularly immunotherapy, enhance efficacy. Methods A comprehensive review was carried out systematically synthesizing existing literature PubMed, using combination keywords “TAMs”, “NSCLC”, “Drug resistance”, “therapy”. available studies were screened for selection quality relevance. Conclusions TAMs promote invasion, growth, metastasis promoting angiogenesis EMT. In addition, they contribute development drug resistance immunosuppressive microenvironment establishment. factors TAM can weaken activity cells, inhibit their killing tumors, leading suppression hindering effectiveness treatment. Therefore, a target immunotherapy. Various being explored, including reducing recruitment influencing treat treatment systems achieve precise delivery drugs gene interfering molecules without causing side effects.

Language: Английский

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