A review of carbohydrate polymer-synthesized nanoparticles in cancer immunotherapy: Past, present and future perspectives DOI
Chunyan Wang, Xueyao Zhang,

Qiaobei Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 286, P. 138195 - 138195

Published: Dec. 5, 2024

Language: Английский

Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential DOI
Na Wu, Wenhui Zheng,

Yundong Zhou

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102428 - 102428

Published: July 20, 2024

Language: Английский

Citations

22
Dual Metal Nanoflower Oxygen Pump Microneedles Based on Cuproptosis and STING Pathway Activation for Cancer Immunotherapy DOI Open Access

Jiaojiao Tao,

Yu Dong, Bingjie Wang

et al.

Small, Journal Year: 2025, Volume and Issue: 21(11)

Published: Feb. 14, 2025

Abstract Immunotherapy is a promising new approach for tumor treatment. However, its clinical application hindered by insufficient immunogenicity, hypoxia, and immunosuppressive microenvironment (TME). Here, oxygen pump microneedles (OPMNs) loaded with zinc‐doped copper sulfide nanoflowers (ZCS NFs) PD‐L1 small interfering RNA (siPD‐L1) (OPMNs‐ZCS@siPD‐L1) are developed boosting immunotherapy. OPMN‐ZCS@siPD‐L1 enhances immunogenicity through ZCS NFs inducing cuproptosis, reverses TME siPD‐L1, promotes drug penetration, ameliorates hypoxia bubbles. More importantly, cuproptosis‐induced mitochondrial DNA (mtDNA) together Zn 2+ co‐activate the STING pathway, triggering robust immune response. increases sensitivity to cuproptosis induces immunogenic cell death (ICD) in vivo vitro, which significantly inhibits progression metastasis. The novel strategy of “increasing throttle” (cuproptopsis‐mediated activation & ICD effect) combined “releasing brake” (PD‐L1 inhibition improvement) provides enhancing percutaneous

Language: Английский

Citations

2
Advances in small-molecule fluorescent probes for the study of apoptosis DOI

Ya‐Xi Ye,

Jian-Cheng Pan, Haichao Wang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(18), P. 9133 - 9189

Published: Jan. 1, 2024

Small-molecule fluorescent probes for studying apoptosis.

Language: Английский

Citations

12
Autophagy in cancer immunotherapy: Perspective on immune evasion and cell death interactions DOI
Qiang Yu,

Jiajun Ding,

Shisen Li

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 590, P. 216856 - 216856

Published: April 5, 2024

Language: Английский

Citations

9
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

Citations

9
Hyaluronic acid-mediated targeted nano-modulators for activation of pyroptosis for cancer therapy through multichannel regulation of Ca2+ overload DOI
Linwei Li,

Zihan Xing,

Jinyu Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140116 - 140116

Published: Jan. 20, 2025

Language: Английский

Citations

0
Multifunctional liposome boosts glioma ferroptosis and immunotherapy through reinforcement of chemo-dynamic therapy strategy DOI Creative Commons
Hongwu Chen,

Jiehao Huang,

Huaiming Wang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101521 - 101521

Published: Jan. 1, 2025

Language: Английский

Citations

0
Prodrug-based combinational nanomedicine remodels lipid metabolism for reinforced ferroptosis and immune activation DOI Creative Commons
Ling Lin,

Zaixiang Fang,

Guohao Liu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Activation of pyroptosis and immunogenic cell death by targeted liposomal cisplatin for enhanced chemo-immunotherapy for osteosarcoma DOI

Jingyou Bi,

Yuchen Han,

Xin-Li Han

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 62, P. 102717 - 102717

Published: March 19, 2025

Language: Английский

Citations

0
M1-macrophage membrane-camouflaged nanoframeworks activate multiple immunity via calcium overload and photo-sonosensitization DOI

Y. B. Shen,

Nuo Yu, Wenjing Zhao

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123287 - 123287

Published: March 1, 2025

Language: Английский

Citations

0