International Immunopharmacology, Journal Year: 2025, Volume and Issue: 157, P. 114782 - 114782
Published: May 6, 2025
Language: Английский
Advanced technology in neuroscience ., Journal Year: 2025, Volume and Issue: 2(1), P. 27 - 33
Published: Feb. 6, 2025
Exosomes is an important tool for intercellular communication, and have gained prominence in medical research recent years. These tiny vesicles can deliver biomolecules such as proteins, lipids, RNA between cells thus play a role variety of biological processes. In addition, exosomes from different cellular sources or with extramembranous factors components show significant differences their functions. The surface modification plays crucial function activity, which compensate the limitations natural exosomes; thus, development technology has led to new possibilities application field medicine. are used carriers drug delivery, structure also enhances loading optimizes delivery process. Therefore, this review attempts summarize functions applications precision medicine by chemical modification, genetic engineering, synthetic methods. medicine, information through targeted encapsulation proteins information, thereby enhancing selectivity receptor cells, increasing concentration drugs lesion site, reducing toxicity side effects, maximizing therapeutic effect. conclusion, not only expands scope but provides ideas methods future clinical treatment.
Language: Английский
Citations
1
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189300 - 189300
Published: March 1, 2025
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1482 - 1482
Published: April 12, 2024
RNA interference is a powerful gene-silencing tool with potential clinical applications. However, its therapeutic use challenging because suitable carriers are unavailable. Exosomes stable small endogenous vesicles that can transport functional molecules to target cells, making them ideal interfering (siRNA) carriers. Herein, we elucidated the of patient-derived exosomes as an siRNA carrier for ovarian cancer (OC) treatment. The were extracted from culture medium primary fibroblasts collected omentum patients OC during surgery. MET proto-oncogene, receptor tyrosine kinase (MET) was selected gene silencing, c-Met siRNAs synthesized and loaded into (Met-siExosomes) via electroporation, treatment effect Met-siExosomes assessed in vitro vivo. downregulated protein levels inhibited cell proliferation, migration, invasion. In xenograft experiments using SKOV3-13 ES-2 selectively peritoneally disseminated tumors. Intraperitoneal suppressed downstream targets cells prolonged mouse survival. successfully delivered intraperitoneally As routinely undergo omentectomy abundant be easily omentum, may represent promising treat OC.
Language: Английский
Citations
8
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 18, 2024
Abstract Chimeric antigen receptor (CAR)-T cell adoptive immunotherapy is a promising cancer treatment that uses genetically engineered T cells to attack tumors. However, this therapy can have some adverse effects. CAR-T cell-derived exosomes are potential alternative may overcome limitations. Exosomes small vesicles released by and carry variety of molecules, including proteins, RNA, DNA. They play an important role in intercellular communication be used deliver therapeutic agents cells. The application could make more clinically controllable effective. cell-free, which means they less likely cause reactions than combination effective way treat either alone. where cannot reach. appropriate both cellular exosomal platforms practicable for cancer. This offer safe cancers.
Language: Английский
Citations
8
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 31, 2024
The malignant form of melanoma is one the deadliest human cancers that accounts for almost all skin tumor-related fatalities in its later stages. Achieving an exhaustive understanding reliable cancer-specific markers and molecular pathways can provide numerous practical techniques direct way toward development rational curative medicines to increase lifespan patients. Immunotherapy has significantly enhanced treatment metastatic late-stage melanoma, resulting incredible positive responses therapy. Despite increasing occurrence median survival rate patients with advanced, inoperable terminal disease increased from around six months years. current knowledge tumor microenvironment (TME) interaction immune system resulted swift growth innovative immunotherapy treatments. Exosomes are small extracellular vesicles (EVs), ranging 30 150 nm size, majority cells released them. possess natural advantages such as high compatibility living organisms low potential causing reactions, making them delivering therapeutic agents like chemotherapy drugs, nucleic acids, proteins. This review highlights recent advancements using exosomes approach providing medications melanoma.
Language: Английский
Citations
8
Cells, Journal Year: 2024, Volume and Issue: 13(8), P. 670 - 670
Published: April 12, 2024
Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS), Huntington’s (HD), stroke, and aneurysms, are characterized by the abnormal accumulation aggregation of disease-causing proteins in brain spinal cord. Recent research suggests that linked to these conditions can be secreted transferred among cells using exosomes. The transmission protein buildup gradual degeneration brains impacted individuals might supported Furthermore, it has been reported neuroprotective functions also attributed exosomes neurodegenerative diseases. potential may play a role preventing formation aggregates associated with disease. present review summarizes roles diseases well elucidating their therapeutic AD, PD, ALS, HD, aneurysms. By two aspects exosomes, valuable insights into targets for treating provided.
Language: Английский
Citations
6
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 13, 2024
Immune dysfunction in early pregnancy including overactivation of cytotoxic CD16
Language: Английский
Citations
6
International Journal of Cancer, Journal Year: 2024, Volume and Issue: 155(1), P. 7 - 18
Published: March 27, 2024
Abstract Immune checkpoint inhibitors (ICIs) have been extensively used in immunological therapy primarily due to their ability prolong patient survival. Although ICIs achieved success cancer treatment, the resistance of should not be overlooked. Ferroptosis is a newly found cell death mode characterized by accumulation reactive oxygen species (ROS), glutathione (GSH) depletion, and peroxidase 4 (GPX4) inactivation, which has demonstrated beneficial immunotherapy combining ferroptosis exploit new immunotherapies may reverse resistance. Exosomes act as mediators cell‐to‐cell communication that regulate influence through secretion biological molecules. Thus, utilizing exosomes target opened up exciting possibilities for reversing In this review, we summarize mechanisms improving how adjusting iron metabolism, blocking ROS accumulation, controlling defense systems, influencing classic signaling pathways engineered improve efficiency.
Language: Английский
Citations
5
Extracellular Vesicle, Journal Year: 2024, Volume and Issue: 3, P. 100044 - 100044
Published: May 13, 2024
Spinal cord injury (SCI) is the damage to spinal causing paralysis below site compromised patient life quality. Exosomes are nanosized vesicles released during physiological or pathological processes. They present a promising avenue for therapeutic drug delivery due their tissue specificity and biocompatibility, offering enhanced efficacy with reduced accumulation-based toxicity. In SCI, exosomes target inflammation, apoptosis, microglial polarization, autophagy, contributing interventions. This article comprehensively explores pathophysiology of diverse exosome synthesis processes, limitations challenges overcome, potential from various cellular sources in SCI treatment.
Language: Английский
Citations
4
Life Sciences, Journal Year: 2024, Volume and Issue: 350, P. 122747 - 122747
Published: May 24, 2024
Language: Английский
Citations
4