Recent Trends in the Development and Application of Nano-Antioxidants for Skin-Related Disease DOI Creative Commons
Yi Xue, Tao Wang, Jipeng Liu

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 27 - 27

Published: Dec. 28, 2024

Skin is a vital barrier for the human body, protecting against external environmental influences and maintaining internal homeostasis. In addition, an imbalance of oxidative stress antioxidant mechanisms can lead to skin-related diseases. Thus, treating diseases, therapy may be important strategy alleviate these symptoms. However, traditional drug therapies have limitations in conditions, such as lack lasting effect insufficient skin permeability. Recently, nano-antioxidants, with their good permeability, sustained-release ability, multifunctionality, other beneficial characteristics, showed advances exploration diseases from research on safe clinical practice. Hereby, we review latest advancements nano-antioxidants We categorize into four main groups: inflammatory damage caused by ultraviolet rays, wound healing, conditions. Additionally, summarize prospects potential future directions nano-antioxidant drugs

Language: Английский

Iron chelators loaded on myocardiocyte mitochondria-targeted nanozyme system for treating myocardial ischemia-reperfusion injury in mouse models DOI Creative Commons
Ke Zhu, Kun Wang,

Rongting Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 15, 2025

Ferroptosis plays a critical role in myocardial ischemia-reperfusion injury (MIRI), posing significant clinical challenge. Nanoenzymes like cerium oxide (CeO2) hold promise for mitigating oxidative damage and inhibiting ferroptosis, but their delivery efficiency biological activity require optimization. This study aims to develop targeted nanozyme system MIRI treatment by integrating CeO2 with mesoporous polydopamine (mPDA) dexrazoxane (DXZ) achieve synergistic therapeutic effects. A biomineralization technique was used synthesize nanoparticles (2–3 nm) within mPDA, forming ~ 130 nm composite (Ce@mPDA). Surface modifications cardiac homing peptide (CHP) triphenylphosphine (TPP) enabled hierarchical targeting injured myocardium mitochondria. DXZ-loaded Ce@mPDA-C/P (D/Ce@mPDA-C/P) were evaluated vitro mouse model effects on stress, apoptosis, inflammation, function. D/Ce@mPDA-C/P exhibited robust ROS scavenging, sustained DXZ release, efficient mitochondrial targeting. The significantly reduced upregulated GPX4 expression, inhibited modulated the inflammatory microenvironment. Long-term studies demonstrated reductions fibrosis improvements function, including enhanced fractional shortening ejection fraction. effectively combines antioxidant properties of iron-chelating DXZ, providing promising strategy MIRI. approach may expand use advance nanomedicine-based interventions repair.

Language: Английский

Citations

1
Progress on mitochondria and hair follicle development in androgenetic alopecia: relationships and therapeutic perspectives DOI Creative Commons

Tingru Dong,

Yujie Li,

Shiyu Jin

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 4, 2025

Hair loss has long been a significant concern for many individuals. Recent studies have indicated that mitochondria play more crucial role in hair than previously recognized. This review summarizes the connection between mitochondrial dysfunction and follicle development, outlines links diseases related to disorders issues, highlights influence of on androgenetic alopecia. We discuss cellular signaling mechanisms associated with examine how dysfunction, such as insufficient energy supply, irregularities, protein/gene abnormalities, programmed cell death, can hinder normal proliferation, differentiation, growth cells. Furthermore, we current treatment approaches potential innovative therapies, including mitochondrion-targeting drugs advanced techniques directly target cells, providing fresh insights into maintaining health managing disorders. this explores future therapeutic strategies proposes research could lead groundbreaking treatments loss, thus optimism new avenues individuals experiencing loss. not only underscores central importance but also emphasizes advancing field.

Language: Английский

Citations

0
Application of Cerium Oxide Nanozymes (CeONZs) in Human Pluripotent Stem Cell-Derived Cardiomyocytes DOI

Chengwen Hang,

Huixin Guo,

Mohamed S. Moawad

et al.

Methods in molecular biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advances in the Treatment of Spinal Cord Injury with Nanozymes DOI
Zuohong Chen, Yili Wang,

Shaofang Zhang

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Spinal cord injury (SCI) with increasing incidence can lead to severe disability. The pathological process involves complex mechanisms such as oxidative stress, inflammation, and neuron apoptosis. Current treatment strategies focusing on the relief of stress inflammation have achieved good effects, while many problems challenges remain side effect short half-life therapeutic agents. Nanozymes exhibiting biocatalytic activities sustainably scavenge free radicals, inhibit neuroinflammation, protect neurons. With high stability in physiological conditions cost-effectiveness, nanozymes provide a new strategy for SCI treatment. In this Review, we outline advances their enzyme-mimicking highlight progress intervention SCI-adopting nanozymes. We also propose future directions clinical translation nanozyme against SCI.

Language: Английский

Citations

0
Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair DOI Creative Commons
Xiaohui Ju, Eliška Javorková, Jan Michalička

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Corneal repair using mesenchymal stem cell therapy faces challenges due to long-term survival issues. Here, we design cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for treating corneal damage in a synergistic combination cells. Powered by glucose, CeSAN-bots exhibit enhanced diffusion and active motion the cascade reaction catalyzed oxide. demonstrate two-fold increase cellular uptake efficiency into cells compared passive uptake. possess intrinsic antioxidant immunomodulatory properties, promoting regeneration. Validation mouse alkali burn model reveals an improvement clarity restoration when are incorporated CeSAN-bots. This work presents strategy developing glucose-driven, enzyme-free, ultrasmall promising applications targeted intracellular delivery diverse biological environments.

Language: Английский

Citations

0
Zinc oxide and its engineered derivative nanomaterials: Insight into energy, environmental, medical, agricultural, and food applications DOI
Gemechu Fikadu Aaga

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: unknown, P. 101051 - 101051

Published: Nov. 1, 2024

Language: Английский

Citations

1
A Nattokinase‐Loaded Nanozyme for Alleviating Acute Myocardial Infarction via Thrombolysis and Antioxidation DOI Open Access
Yingchao Shi, Chuan‐Fen Liu, Yuesheng Gui

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Acute myocardial infarction (MI) induced by thrombus formation is a prevalent cardiovascular disorder, and thrombolytic therapy continues to be principal treatment modality. Prior research indicates substantial association among MI, thrombosis, the activation of oxidative stress pathways. The effectiveness current drugs relatively constrained, need for innovative versatile medications remains critical. Nattokinase (NK) naturally-occurring enzyme known its characteristics. Nonetheless, nattokinase's limited stability susceptibility inactivation in biological systems have impeded clinical utility. This study designs manganese oxide nanozyme (MnOx) loaded with NK (MnOx@NK), which exhibits both antioxidant function. administration MnOx@NK through tail vein injection significantly restores vascular function further reduces injury mouse model infarction, demonstrating pronounced protective effect against stress. These findings indicate that nattokinase-loaded nanozymes can promising approach treating acute providing new strategy application.

Language: Английский

Citations

0
Recent Trends in the Development and Application of Nano-Antioxidants for Skin-Related Disease DOI Creative Commons
Yi Xue, Tao Wang, Jipeng Liu

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 27 - 27

Published: Dec. 28, 2024

Skin is a vital barrier for the human body, protecting against external environmental influences and maintaining internal homeostasis. In addition, an imbalance of oxidative stress antioxidant mechanisms can lead to skin-related diseases. Thus, treating diseases, therapy may be important strategy alleviate these symptoms. However, traditional drug therapies have limitations in conditions, such as lack lasting effect insufficient skin permeability. Recently, nano-antioxidants, with their good permeability, sustained-release ability, multifunctionality, other beneficial characteristics, showed advances exploration diseases from research on safe clinical practice. Hereby, we review latest advancements nano-antioxidants We categorize into four main groups: inflammatory damage caused by ultraviolet rays, wound healing, conditions. Additionally, summarize prospects potential future directions nano-antioxidant drugs

Language: Английский

Citations

0