From pancreas to lungs: The role of immune cells in severe acute pancreatitis and acute lung injury

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(7)

Published: July 1, 2024

Abstract Background Severe acute pancreatitis (SAP) is a potentially lethal inflammatory condition that usually linked to multiple organ failure. When it comes SAP, the lung main frequently involved. Many SAP patients experience respiratory failure following an injury (ALI). Clinicians provide insufficient care for compounded ALI since underlying pathophysiology unknown. The mortality rate of severely impacted by it. Objective study aims insight into immune cells, specifically their roles and modifications during ALI, through comprehensive literature review. emphasis on cells as therapeutic approach treating ALI. Findings Immune play important role in complicated ofSAP maintaining right balance pro‐ anti‐inflammatory responses. Immunomodulatory drugs now market have low thepeutic efficacy because they selectively target one cell while ignoring interactions. Accurate management dysregulated responses necessary. A critical initial step precisely characterizing activity Conclusion Given increasing incidence immunotherapy emerging potential treatment option these patients. Interactions among improve our understanding intricacy concurrent Acquiring expertise domains will stimulate development innovative immunomodulation therapies outlook with

Language: Английский

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Extracellular Vesicle-based Delivery of Paclitaxel to Lung Cancer Cells: Uptake, Anticancer Effects, Autophagy and Mitophagy Pathways

Archives of Medical Research, Journal Year: 2025, Volume and Issue: 56(4), P. 103194 - 103194

Published: Feb. 7, 2025

Language: Английский

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Engineered exosomes: a promising drug delivery platform with therapeutic potential

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: May 9, 2025

Exosomes, small membranous vesicles naturally secreted by living cells, have garnered attention for their role in intercellular communication and therapeutic potential. Their low immunogenicity, high biocompatibility, efficient biological barrier penetration make them promising drug delivery vehicles. This review spans research developments from 2010 to 2025, covering the engineering of exosomes optimize cargo loading targeting specificity. We discuss applications treating cardiovascular diseases, liver fibrosis, immune neurological alongside ongoing clinical trials industry progress. Future challenges include scalability, standardization, minimizing off-target effects. propose strategies address these hurdles, such as bioengineering techniques improved isolation methods. By synthesizing current knowledge outlining future directions, this aims guide researchers toward harnessing disease treatment.

Language: Английский

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Z jedrsko magnetno resonanco v strukturno raznolikost DNK

Alternator, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 6, 2024

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