Epigenetics-targeted drugs: current paradigms and future challenges

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Nov. 26, 2024

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone RNA remodeling, and non-coding regulation. These mechanisms their associated enzymes convey genetic information independently of base sequences, playing essential roles in organismal development homeostasis. Conversely, disruptions epigenetic landscapes critically influence the pathogenesis various human diseases. This understanding has laid robust theoretical groundwork for developing drugs that target epigenetics-modifying pathological conditions. Over past two decades, growing array small molecule targeting such as methyltransferase, deacetylase, isocitrate dehydrogenase, enhancer zeste homolog 2, have been thoroughly investigated implemented therapeutic options, particularly oncology. Additionally, numerous epigenetics-targeted are undergoing clinical trials, offering promising prospects benefits. review delineates epigenetics physiological contexts underscores pioneering studies on discovery implementation drugs. include inhibitors, agonists, degraders, multitarget agents, aiming to identify practical challenges avenues future research. Ultimately, this aims deepen epigenetics-oriented strategies further application settings.

Language: Английский

UiO-based platforms in biomedicine: Advanced nanovehicles for effective treatment

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102645 - 102645

Published: March 22, 2025

Language: Английский

Immunoglobulin-binding protein and Toll-like receptors in immune landscape of breast cancer

Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123196 - 123196

Published: Oct. 1, 2024

Language: Английский