Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Microneedle
patches
have
emerged
as
a
promising
approach
for
diabetic
wound
healing
by
enabling
the
targeted
delivery
of
therapeutic
agents
such
stem
cells
and
their
derived
exosomes,
well
localized
bioactive
moieties.
These
offer
non-invasive
efficient
method
administering
payloads
directly
to
site
wound,
bypassing
systemic
circulation
minimizing
potential
side
effects.
The
holds
immense
promoting
tissue
regeneration
accelerating
in
patients.
Similarly,
cell-derived
which
are
known
regenerative
anti-inflammatory
properties,
can
enhance
process.
Furthermore,
microneedle
enable
precise
controlled
release
moieties,
growth
factors
cytokines,
site,
creating
conducive
microenvironment
repair
regeneration.
challenges
associated
with
multifaceted.
Biocompatibility
issues,
variability
skin
characteristics
among
patients,
regulatory
hurdles,
scalability,
cost
considerations,
long-term
stability,
patient
acceptance
compliance
all
present
significant
barriers
widespread
adoption
optimization
technology
clinical
practice.
Overcoming
these
will
require
collaborative
efforts
from
various
stakeholders
advance
field
address
critical
gaps
research
development.
Ongoing
focuses
on
enhancing
biocompatibility
mechanical
properties
materials,
developing
customizable
technologies
personalized
treatment
approaches,
integrating
advanced
functionalities
sensors
real-time
monitoring,
improving
engagement
adherence
through
education
support
mechanisms.
advancements
improve
management
providing
tailored
therapies
that
promote
faster
reduce
complications.
This
review
explores
current
landscape
context
management,
highlighting
both
need
be
addressed
future
perspectives
this
innovative
modality.
Burns & Trauma,
Journal Year:
2025,
Volume and Issue:
13
Published: Jan. 1, 2025
Abstract
Diabetic
wounds
present
a
significant
challenge
in
clinical
treatment
and
are
characterized
by
chronic
inflammation,
oxidative
stress,
impaired
angiogenesis,
peripheral
neuropathy,
heightened
risk
of
infection
during
the
healing
process.
By
creating
small
channels
surface
skin,
microneedle
technology
offers
minimally
invasive
efficient
approach
for
drug
delivery
treatment.
This
article
begins
outlining
biological
foundation
normal
skin
wound
unique
pathophysiological
mechanisms
diabetic
wounds.
It
then
delves
into
various
types,
materials,
preparation
processes
microneedles.
The
focus
is
on
application
multifunctional
microneedles
treatment,
highlighting
their
antibacterial,
anti-inflammatory,
immunomodulatory,
antioxidant,
angiogenic
neural
repair
properties.
These
demonstrate
synergistic
therapeutic
effects
directly
influencing
microenvironment,
ultimately
accelerating
advancement
not
only
holds
promise
enhancing
outcomes
but
also
new
strategies
addressing
other
Microbial Biotechnology,
Journal Year:
2024,
Volume and Issue:
17(10)
Published: Oct. 1, 2024
Infected
wounds
can
result
in
complex
clinical
complications
and
delayed
healing,
presenting
a
significant
global
public
health
challenge.
This
study
explored
the
effects
of
topical
application
two
probiotics,
Lactobacillus
rhamnosus
GG
(LGG)
Bifidobacterium
animalis
subsp.
lactis
BB-12,
on
microenvironment
infected
their
impact
wound
healing.
LGG
BB-12
were
applied
separately
topically
Staphylococcus
aureus
(S.
aureus)-infected
skin
rat
model
daily
basis.
Both
probiotics
significantly
accelerated
demonstrated
by
enhanced
granulation
tissue
formation
increased
collagen
deposition,
with
showing
superior
efficacy.
both
effectively
inhibited
neutrophil
infiltration
decreased
expression
pro-inflammatory
cytokines
tumor
necrosis
factor-α
(TNF-α)
interleukin-6
(IL-6).
Notably,
markedly
reduced
IL-6
levels,
while
lowered
TNF-α,
transforming
growth
factor-β
(TGF-β)
vascular
endothelial
factor
(VEGF).
Additionally,
promoted
macrophage
polarization
towards
anti-inflammatory
M2
phenotype.
Microbiota
analysis
revealed
that
abundance
pathogenic
bacteria
(e.g.
Proteus)
proportion
beneficial
Corynebacterium).
Particularly,
was
more
effective
reducing
abundance,
whereas
excelled
promoting
Corynebacterium
growth.
These
findings
suggest
ability
to
modulate
microenvironment,
enhance
healing
provide
valuable
insights
for
management
wounds.
IP Journal of Surgery and Allied Sciences,
Journal Year:
2025,
Volume and Issue:
6(4), P. 131 - 134
Published: Jan. 15, 2025
Despite
insulin's
well-documented
benefits
in
wound
healing
over
the
last
70
years,
challenges
remain
regarding
optimal
method
of
administration.
While
systemic
insulin
therapy
has
significant
side
effects,
topical
faces
with
consistent
delivery.
This
study
aims
to
test
hypothesis
that
local
injections
can
provide
sustained
high
concentrations
wounds,
promoting
minimal
impact,
combining
both
and
therapies.
investigates
effect
on
healing,
focusing
enhancing
process
a
non-healing
diabetic
foot
ulcer.
The
objective
is
determine
whether
at
site
accelerate
by
key
processes
like
keratinocyte
migration,
differentiation,
angiogenesis.
Conducted
tertiary
care
center
South
India,
this
involved
69-year-old
male
patient
ulcer
lateral
aspect
left
due
Charcot's
joint.
area
was
treated
mixture
Insulin
Isophane
Human
(70/30)
4-unit
10
ml
saline
ratio
per
cm².
treatment
followed
two-layer
regenerative
scaffold
dressing
Negative
Pressure
Wound
Therapy
(NPWT)
support
recovery.
application
significantly
enhanced
These
effects
led
noticeable
reduction
time
required
for
closure
improved
tissue
regeneration.
use
effectively
improves
targeting
such
as
inflammation,
re-epithelialization,
underscores
potential
promising
therapeutic
agent
chronic
management.
Further
research
recommended
validate
these
findings
explore
its
across
diverse
types.
