Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration DOI Creative Commons

Churong Xu,

Fei Wu,

Zhouyi Duan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 3, 2025

Language: Английский

Engineered protein-based materials for tissue repair: A review DOI
Jiayin Feng, Fangyan Wang,

Yunyuan Shao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140674 - 140674

Published: Feb. 3, 2025

Language: Английский

Citations

6
Borate ester-crosslinked polysaccharide hydrogel reinforced by proanthocyanidins for oral ulcer therapy DOI

Yan Ge,

Mingjing Wang, Yang Zhou

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114535 - 114535

Published: Jan. 1, 2025

Language: Английский

Citations

1
Dissolving microneedles: drug delivery and disease treatment DOI

Yanling Zhuo,

F.Z. Wang, Qizhuang Lv

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114571 - 114571

Published: Feb. 1, 2025

Language: Английский

Citations

1
Polyphenol‐Modified Mg−Zn Layered Hydroxide‐Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic Oral Microenvironment DOI Open Access
Haibo Liu, Zhongyi Sun, Lanying Li

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Diabetic oral ulcers pose a significant challenge in healing due to persistent inflammation. Despite local therapeutic interventions remaining the primary mode of treatment, dynamic nature cavity, characterized by continuous muscular activity and salivary secretion, poses barriers sustained drug retention thereby limits efficacy. To address this issue, an approach has been devised that aims facilitate transdermal delivery bioactive components promote diabetic ulcers. A multifunctional soluble microneedle (MN) patch is prepared using γ‐polyglutamic acid (γ‐PGA), which loaded with quercetin (Qu)‐modified Mg−Zn layered hydroxide salt (LHS) nanosheets (LHSQ) anti‐inflammatory, antimicrobial pro‐angiogenic bioactivities combat These findings demonstrate LHSQ‐loaded MN (LHSQ‐MN) patches are capable effectively penetrating mucosa. In rat model ulcers, application LHSQ‐MN found establishment regeneration sites, regulate inflammatory microenvironment damaged tissues, exhibit potent antibacterial effects, expedite reconstitution mucosal epithelium, accelerate ulcer through promotion angiogenesis. outcomes highlight potential as promising strategy for management patients.

Language: Английский

Citations

0
Dual Enzyme-Mimic Popcorn-Shaped Copper–Erbium Nanoalloys for Combating Gram-Negative Pathogens and Promoting Wound Healing DOI
Arbab Ali, Tao Liu, Jiakun Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
A gelatin microneedles featuring antibacterial and reactive oxygen species scavenging properties for treating Vibrio vulnificus-infected wounds DOI

Yuling Shu,

Yi Qi, Yan Zou

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142640 - 142640

Published: March 1, 2025

Language: Английский

Citations

0
Antibacterial antioxidant polyurethane/curcumin patch with anti-swelling ability for tissue adhesion and treatment of oral ulcers DOI
Xiaolei Guo, Lin Yang, Nan Sheng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162131 - 162131

Published: March 1, 2025

Language: Английский

Citations

0
Biomimetic Piezoelectric Periosteum‐Bone Integrated Implant Promotes Bone Defect Repair by Remodeling Osteogenic Microenvironment DOI
Xiaokun Yue,

Xueheng Sun,

Zilin Li

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Bone defects caused by trauma, infection, or tumors pose significant clinical challenges, particularly in large with poor healing outcomes. Traditional repair methods often fail to address the complex regenerative microenvironment. This study introduces a novel biomimetic piezoelectric periosteum‐bone bilayer implant designed remodel osteogenic microenvironment and enhance bone defect repair. The comprises an upper electrospun polyvinylidene fluoride‐curcumin‐loaded magnesium metal–organic framework (PVDF‐MOF/Cur, PMC) periosteum scaffold lower hydroxyapatite@gelatin methacrylate (HA@GelMA) (PMC+HA@GelMA, PMCG). In whole PMCG implant, PMC improves properties of PVDF enables sustained drug release via Mg‐MOF loaded Cur. Meanwhile, HA@GelMA facilitates marrow mesenchymal stem cells differentiation regeneration. Additionally, further accelerates promoting neuronal differentiation, as well enhancing angiogenesis regulating macrophage polarization. Transcriptome sequencing reveals that activates key signaling pathways associated angiogenesis, neurogenesis, inflammation regulation, osteogenesis, including HIF‐1α, PI3K‐Akt, JAK‐STAT, TGF‐β pathways. Thus, this work highlights multifunctional capabilities remodify accelerate repair, which offers promising platform for advancing tissue

Language: Английский

Citations

0
Metal-organic frameworks-molecularly imprinted polymers (MOF-MIP): Synthesis, properties, and applications in detection and control of microorganisms DOI
Yen P. Kong, Yuhan Sun, Z. Ryan Tian

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 252, P. 114670 - 114670

Published: April 6, 2025

Language: Английский

Citations

0
Metal ion crosslinked polysaccharide hydrogels: A review on their potential for therapeutic delivery and tissue engineering DOI

Riya Hazra,

Md Sahil Shanawaz Alam,

Ashim Malakar

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143467 - 143467

Published: April 23, 2025

Language: Английский

Citations

0