Talanta, Journal Year: 2025, Volume and Issue: 288, P. 127724 - 127724
Published: Feb. 11, 2025
Language: Английский
Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 272, P. 117135 - 117135
Published: Jan. 5, 2025
Language: Английский
Citations
3
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
The development of intelligent nanotheranostic technology that integrates diagnostic and therapeutic functions holds great promise for personalized nanomedicine. However, most the agents exhibit "always-on" properties do not involve an amplification step, which may largely limit imaging contrast restrict efficacy. Herein, we construct a novel platform (Hemin/DHPs/PDA@CuS nanocomposite) by assembling DNA hairpin probes (DHPs) hemin on surface PDA@CuS nanosheets enables amplified fluorescence activatable chemodynamic therapy (CDT) tumors. cancer-relevant APE1 triggers nucleic acid with DHPs to generate signals discriminating cancer cells from normal cells. Meanwhile, excessive G-quadruplex/hemin-based DNAzyme are also activated, they function as Fenton-like catalysts catalyze production highly toxic hydroxyl radicals (•OH) CDT. Moreover, owing excellent photothermal conversion efficiency in near-infrared-II (NIR-II) window, only improves catalytic performance CDT but furnishes PTT. A remarkable antitumor effect is demonstrated both vitro vivo. Therefore, Hemin/DHPs/PDA@CuS nanocomposite expected provide promising avenue precise imaging-guided therapy.
Language: Английский
Citations
0
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
The DNA repair system relies on the coordinated action of multiple enzymes to maintain genomic stability, with apurinic/apyrimidinic endonuclease 1 (APE1) and flap (FEN1) playing pivotal roles in long-patch base excision (LP-BER) pathway. Elevated levels APE1 FEN1 have been associated tumor progression resistance therapy, making them key biomarkers for cancer diagnosis treatment monitoring. Here, we present a sequentially activated AND-logic sensor (D-AF) correlated imaging living cells. operates through sequential process: first recognizes cleaves an apurinic site, initiating structural changes that enable cleave 5' flap, resulting restored fluorescence. We demonstrate use D-AF-based nanosensor situ activities cells monitoring enzyme dynamics during chemotherapy. This platform offers valuable tool investigating mechanisms their treatment.
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1025 - 1025
Published: Feb. 24, 2025
Mitochondria, as vital organelles, play a central role in subcellular research and biomedical innovation. Although functional nucleic acid (FNA) nanostructures have witnessed remarkable progress across numerous biological applications, strategies specifically tailored to target mitochondria for molecular imaging therapeutic interventions remain scarce. This review delves into the latest advancements leveraging FNA mitochondria-specific cancer therapy. Initially, we explore creation of FNA-based biosensors localized mitochondria, enabling real-time detection visualization critical molecules essential mitochondrial function. Subsequently, examine developments aimed at mitochondrial-targeted treatments, including modular nanodevices precise delivery agents programmable disrupting processes. Emphasis is placed on elucidating chemical principles underlying design mitochondrial-specific nanotechnology diverse uses. Lastly, address unresolved challenges outline prospective directions, with goal advancing field encouraging sophisticated tools both academic inquiry clinical applications centered mitochondria.
Language: Английский
Citations
0
Talanta, Journal Year: 2025, Volume and Issue: 288, P. 127724 - 127724
Published: Feb. 11, 2025
Language: Английский
Citations
0