Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 77(1), P. 93 - 113

Published: Aug. 3, 2019

Language: Английский

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Risks to Health and Well-Being From Radio-Frequency Radiation Emitted by Cell Phones and Other Wireless Devices

Frontiers in Public Health, Journal Year: 2019, Volume and Issue: 7

Published: Aug. 13, 2019

Radiation exposure has long been a concern for the public, policy makers and health researchers. Beginning with radar during World War II, human to radio-frequency radiation (RFR) technologies grown more than 100,000-fold over time. In 2011, International Agency Research on Cancer (IARC) reviewed published literature categorized RFR as 'possible' (Group 2B) carcinogen. A broad range of adverse effects associated have reported since IARC review. addition, three large-scale carcinogenicity studies in rodents exposed levels that mimic lifetime exposures shown significantly increased rates Schwannomas malignant gliomas, well chromosomal DNA damage. Of particular are developing brain children. Compared an adult male, cell phone held against head child exposes deeper structures greater doses per unit volume, young, thin skull's bone marrow absorbs roughly 10-fold higher local dose. Recent reports also suggest men who keep phones their trouser pockets lower sperm counts impaired motility morphology, including mitochondrial Based accumulated evidence, we recommend re-evaluate its 2011 classification RFR, WHO complete systematic review multiple other such interim, current knowledge provides justification governments, public authorities, physicians/allied professionals warn population having next body is harmful, support measures reduce all RFR.

Language: Английский

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Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 9288 - 9288

Published: Aug. 18, 2022

Modern humanity wades daily through various radiations, resulting in frequent exposure and causing potentially important biological effects. Among them, the brain is organ most sensitive to electromagnetic radiation (EMR) exposure. Despite numerous correlated studies, critical unknowns surround different parameters used, including operational frequency, power density (i.e., energy dose), irradiation time that could permit reproducibility comparability between analyses. Furthermore, interactions of EMR with systems its precise mechanisms remain poorly characterized. In this review, recent approaches examining effects microwave radiations on brain, specifically learning memory capabilities, as well dysfunction reported literature, are analyzed interpreted provide prospective views for future research directed at novel medical technology developing preventive therapeutic strategies degeneration caused by radiation. Additionally, microwaves possible presented review. Treatment natural products safe techniques reduce harm organs have become essential components life, some promising treat cancers their radioprotective summarized well. This review can serve a platform researchers understand mechanism systems, present scenario, prospects studies effect brain.

Language: Английский

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Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 198 - 198

Published: Feb. 11, 2024

Semen quality represents a compelling factor for fertility, and delineating the normal values has proven difficult. In last four decades, several authors have reported noticeable decline in sperm parameters. Also, studies investigating ‘time to pregnancy’ shown that fecundity begins be reduced when numbers decrease below 30 million, even though according 6th edition of WHO manual, value is currently 16 million/mL or 39 million per ejaculate. There exists sufficient data suggest counts over time, clear reason this adverse trend not well established, but some associations been hypothesised, such as maternal smoking during pregnancy. Additional potential factors yet fully illustrated involve poor diet, increased obesity, exposure environmental toxins. Moreover, change conditions more common endocrine-disrupting chemicals (EDCs), pesticides herbicides, bisphenol A, phthalates, polychlorinated biphenyls, heavy metals, starting from prenatal life continuing into adulthood, may exhibit probable features explaining reduction Therefore, main goal narrative review furnish an overview possible effects EDCs on testicular function spermatogenesis and, also, summarise evidence regarding examine its consequences.

Language: Английский

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Mechanisms of oxidative stress-induced sperm dysfunction

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Oxidative stress plays a pivotal role in male infertility by impairing sperm function through various molecular mechanisms. This review explores the impact of excessive reactive oxygen species (ROS) on spermatozoa, particularly focusing lipid peroxidation, DNA fragmentation, and protein oxidation. Lipid peroxidation damages membranes, reducing fluidity motility. ROS-induced fragmentation compromises genetic integrity, potentially leading to adverse offspring outcomes. Protein oxidation alters key structural proteins, motility ability fertilize an egg. The primary sources oxidative include leukocyte activity, mitochondrial dysfunction, environmental factors such as smoking pollution. Despite presence natural antioxidant defenses, spermatozoa are vulnerable due limited repair highlights importance early intervention therapies lifestyle changes mitigate detrimental effects fertility. Further research is essential enhance therapeutic approaches improve reproductive

Language: Английский

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Exploring the impact of environmental factors on male reproductive health through epigenetics

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: 132, P. 108832 - 108832

Published: Jan. 6, 2025

Language: Английский

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Oxidative-Stress-Mediated Epigenetic Dysregulation in Spermatogenesis: Implications for Male Infertility and Offspring Health

Genes, Journal Year: 2025, Volume and Issue: 16(1), P. 93 - 93

Published: Jan. 17, 2025

Male reproductive health is governed by an intricate interplay of genetic, epigenetic, and environmental factors. Epigenetic mechanisms—encompassing DNA methylation, histone modifications, non-coding RNA activity—are crucial both for spermatogenesis sperm maturation. However, oxidative stress, driven excessive reactive oxygen species, disrupts these processes, leading to impaired function male infertility. This disruption extends epigenetic resulting in abnormal gene expression chromatin remodeling that compromise genomic integrity fertilization potential. Importantly, oxidative-stress-induced alterations can be inherited, affecting the fertility offspring future generations. review investigates how stress influences regulation reproduction modifying RNAs, ultimately compromising spermatogenesis. Additionally, it discusses transgenerational implications disruptions their potential role hereditary infertility disease predisposition. Understanding mechanisms vital developing therapeutic strategies mitigate damage restore homeostasis germline. By integrating insights from molecular, clinical, research, this work emphasizes need targeted interventions enhance prevent adverse outcomes progeny. Furthermore, elucidating dose–response relationships between changes remains a critical research priority, informing personalized diagnostics interventions. In context, studies should adopt standardized markers damage, robust clinical trials, multi-omic approaches capture complexity Such rigorous investigations will reduce risk disorders optimize outcomes.

Language: Английский

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Diet and Nutritional Factors in Male (In)fertility—Underestimated Factors

Journal of Clinical Medicine, Journal Year: 2020, Volume and Issue: 9(5), P. 1400 - 1400

Published: May 9, 2020

In up to 50% of cases, infertility issues stem solely from the male. According some data, quality human semen has deteriorated by 50%-60% over last 40 years. A high-fat diet and obesity, resulting an unhealthy lifestyle, affects structure spermatozoa, but also development offspring their health in later stages life. obese individuals, disorders on hypothalamic-pituitary-gonadal axis are observed, as well elevated oestrogen levels with a simultaneous decrease testosterone, luteinizing hormone (LH), follicle-stimulating (FSH) levels. Healthy dietary models clearly correlate better sperm smaller risk abnormalities parameters such count, concentration motility, lower DNA fragmentation. Apart mineral components zinc selenium, role omega-3 fatty acids antioxidant vitamins should be emphasized, since action will primarily based minimization oxidative stress inflammation process. Additionally, incorporation carnitine supplements coenzyme Q10 therapeutic interventions seems promising. Therefore, it is advisable have varied balanced vegetables fruit, fish seafood, nuts, seeds, whole-grain products, poultry, low-fat dairy products.

Language: Английский

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Reasons for worldwide decline in male fertility

Current Opinion in Urology, Journal Year: 2020, Volume and Issue: 30(3), P. 296 - 301

Published: March 11, 2020

To review the evidence regarding a decrease in worldwide sperm parameters and discuss potential causative factors.The topic of decline is contentious; however, recent high-quality studies have demonstrated that there indeed parameters. Several retrospective basic science shown possible links for this such as obesity, diet, environmental toxins.There exist substantial data to suggest counts over time. Although factors yet be fully elucidated, causes include, increased rates poor exposure toxins. How reflects fertility has determined. As such, further are necessary evaluate whether count correlates with decreased fecundity how identify mitigate factors.

Language: Английский

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Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction

Reproductive Sciences, Journal Year: 2020, Volume and Issue: 29(1), P. 7 - 25

Published: Dec. 7, 2020

Abstract Spermatozoon is a motile cell with special ability to travel through the woman’s reproductive tract and fertilize an oocyte. To reach penetrate oocyte, spermatozoa should possess progressive motility. Therefore, motility important parameter during both natural assisted conception. The global trend of reduction in number healthy ejaculate associated increased risk infertility. developing approaches for maintaining or enhancing human sperm has been area investigation. In this review we discuss physiology sperm, molecular pathways regulating motility, factors affecting role fertility outcomes. addition, various pharmacological agents biomolecules that can enhance vitro vivo conditions improve technology (ART) This article opens dialogs help toxicologists, clinicians, andrologists, embryologists understanding mechanism influencing management strategies treatment

Language: Английский

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