American Journal of Men s Health,
Journal Year:
2024,
Volume and Issue:
18(6)
Published: Nov. 1, 2024
Antioxidants
act
by
preventing
excessive
oxidative
stress
within
the
developing
sperm
cells.
Hookah
smoking
has
been
implicated
in
inducing
which
may
be
a
risk
factor
for
male
infertility.
This
study
aims
to
bridge
this
knowledge
gap
evaluating
effect
of
hookah
on
quality
and
expression
nuclear
erythroid
2-related
2
(
NRF2)
Cytochrome
P450
family
24
subfamily
A
member
1
CYP24A1)
genes
are
involved
antioxidant
response.
Young
fertile
men
reproductive
age
were
categorized
into
smokers
n
=
32)
non-smokers
(n=52).
Sperm
parameters
(concentration,
volume,
motility,
morphology)
as
well
gene
NRF2
CYP24A1
evaluated
each
sample.
There
was
no
meaningful
change
case
group
compared
with
controls.
The
mRNA
levels
significantly
higher
controls
p
0.01),
while
did
not
between
groups.
remarkable
increase
might
cellular
defense
mechanism,
indicating
activation
response
counteract
potential
caused
use.
However,
further
research
is
needed
understand
functional
consequences
upregulation.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 993 - 993
Published: Jan. 24, 2025
Telomeres
protect
chromosome
ends
from
damage,
but
they
shorten
with
each
cell
division
due
to
the
limitations
of
DNA
replication
and
are
further
affected
by
oxidative
stress.
This
shortening
is
a
key
feature
aging,
telomerase,
an
enzyme
that
extends
telomeres,
helps
mitigate
this
process.
Aging
also
associated
mitochondrial
dysfunction,
leading
increased
reactive
oxygen
species
(ROS)
exacerbate
cellular
damage
promote
apoptosis.
Elevated
ROS
levels
can
telomeres
oxidizing
guanine
disrupting
their
regulation.
Conversely,
telomere
impacts
function,
activation
telomerase
has
been
shown
reverse
decline.
A
critical
link
between
dysfunction
response,
which
activates
tumor
suppressor
protein
p53,
resulting
in
reduced
biogenesis
metabolic
disruptions.
highlights
bidirectional
relationship
maintenance
function.
review
explores
complex
interactions
mitochondria
across
various
types,
fibroblasts
sperm
cells,
shedding
light
on
interconnected
mechanisms
underlying
aging
Aging Cell,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 4, 2025
ABSTRACT
Recent
studies
have
shown
that
disruptions
in
the
nicotinamide
adenine
dinucleotide
(NAD
+
)
de
novo
synthesis
pathway
accelerate
ovarian
aging,
yet
its
role
spermatogenesis
remains
largely
unknown.
In
this
study,
we
investigated
impact
of
NAD
on
by
generating
Qprt
‐deficient
mice
using
CRISPR‐Cas9
to
target
quinolinate
phosphoribosyl
transferase
(
),
a
key
enzyme
predominantly
expressed
spermatocytes.
Our
results
revealed
deletion
did
not
affect
levels
or
testes
3‐month‐old
mice.
However,
from
6
months
age
onward,
exhibited
significantly
reduced
compared
wild‐type
(WT)
controls,
along
with
notable
decrease
germ
cell
numbers
and
increased
apoptosis.
Additionally,
these
demonstrated
mitochondrial
dysfunction
spermatocytes,
impaired
progression
through
prophase
I
meiosis,
defective
double‐strand
break
(DSB)
repair,
abnormal
meiotic
sex
chromosome
inactivation.
Importantly,
supplementation
precursor
riboside
(NR)
restored
rescued
spermatogenic
defects.
These
findings
underscore
critical
maintaining
homeostasis
highlight
importance
recombination
inactivation
spermatogenesis.
Asian Journal of Andrology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Abstract
Extensive
studies
have
identified
potential
adverse
effects
on
semen
quality
of
obesity,
based
body
mass
index,
but
the
association
between
fat
distribution,
a
more
relevant
indicator
for
and
remains
less
clear.
We
conducted
longitudinal
study
4304
sperm
donors
from
Guangdong
Provincial
Human
Sperm
Bank
(Guangzhou,
China)
during
2017–2021.
A
composition
analyzer
was
used
to
measure
total
local
percentage
each
participant.
Generalized
estimating
equations
were
employed
assess
count,
motility,
morphology.
estimated
that
10%
increase
in
(estimated
change
[95%
confidence
interval,
95%
CI])
significantly
associated
with
0.18
×
10
6
(0.09
–0.27
)
ml
12.21
(4.52
–19.91
reduction
volume
respectively.
Categorical
analyses
exposure-response
curves
showed
distribution
count
stronger
at
higher
percentages.
In
addition,
still
held
among
normal
weight
overweight
participants.
observed
similar
associations
upper
limb,
trunk,
lower
limb
fact
distributions.
conclusion,
we
found
(especially
volume)
even
men
weight.
These
findings
provide
useful
clues
exploring
as
risk
factor
decline
add
evidence
improving
those
who
are
expected
conceive.
Journal of Pharmacy and Nutrition Sciences,
Journal Year:
2025,
Volume and Issue:
15, P. 1 - 14
Published: Feb. 20, 2025
Turmeric,
derived
from
the
rhizome
of
Curcuma
longa,
is
a
widely
utilized
spice.
It
characterized
by
warm
and
slightly
bitter
flavor,
often
employed
to
enhance
taste
color
curry
powders.
The
active
compound,
curcumin
has
been
subject
extensive
research
due
its
anti-inflammatory,
antioxidant,
potential
anticancer
properties,
among
others.
This
review
explores
therapeutic
curcumin,
ingredient
in
turmeric,
for
male
reproductive
health,
going
beyond
culinary
uses.
articles
used
this
narrative
were
obtained
some
search
engines
including
National
Library
Medicine
(PubMed),
Science
Alert,
Google
Scholar,
Excerta
Medical
database
(EMBASE)
Cumulated
Index
Nursing
Allied
Health
Literature
(CINAHL).
summarizes
current
scientific
evidence
regarding
curcumin's
effects
on
various
aspects
fertility,
sperm
quality.
also
highlights
anti-apoptotic
properties
how
these
contribute
benefits
addressing
issues.
Evidence
overview
existing
literature
suggests
supplementation
alleviating
infertility.
An
avenue
future
investigations
into
role
maintaining
improving
health
human
open.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 478 - 478
Published: March 25, 2025
Oxidative
stress
is
a
significant
factor
that
contributes
to
male
infertility
and
sperm
dysfunction.
In
this
condition,
an
increase
in
ROS
production
exceeds
the
body's
antioxidant
defenses,
resulting
decline
spermatozoa
quality
fertilizing
capacity.
Furthermore,
excessive
has
been
linked
promotion
of
genomic
damage,
lipid
peroxidation,
inflammation,
altered
enzyme
activity,
ultimately,
irreversible
alterations,
cell
death,
seminal
parameters
associated
with
infertility.
It
established
physical
activity
(PA),
acting
on
inflammatory
improving
defense,
can
alleviate
negative
effects
caused
by
free
radicals,
offering
numerous
health
benefits
positively
influencing
quality.
The
objective
review
highlight
mechanisms
production,
physiological
pathophysiological
roles
relation
reproductive
system,
recent
knowledge
impact
some
protocols
PA
these
systems
molecular
involved.
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(4), P. 267 - 267
Published: April 11, 2025
Inflammation,
infections,
and
oxidative
stress
(OS)
all
have
an
impact
on
male
infertility,
which
is
a
complicated,
multifaceted
illness.
OS
affects
motility
fertilization
capability.
It
accomplishes
this
through
damaging
sperm
DNA,
oxidizing
proteins,
triggering
lipid
peroxidation.
These
effects
occur
due
to
imbalance
between
reactive
oxygen
species
(ROS)
antioxidant
defenses.
This
review
aims
evaluate
the
of
inflammation
infertility
by
assessing
recent
literature.
Pro-inflammatory
cytokines,
like
TNF-α
IL-6,
interfere
with
spermatogenesis
promote
damage.
Additionally,
infections
caused
pathogens
Escherichia
coli
Chlamydia
trachomatis
alter
reproductive
microenvironment,
leading
dysfunction
inflammation.
Early
detection
targeted
treatment
are
essential
intricate
interactions
among
these
elements.
Microbiota-modulating
techniques,
antimicrobial
therapies,
anti-inflammatory
drugs,
antioxidants
therapeutic
approaches
that
may
help
reduce
damage
enhance
fertility.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 488 - 488
Published: April 18, 2025
A
randomized,
placebo-controlled,
quadruple-blind
trial
was
performed
to
evaluate
the
effect
of
oral
administration
antioxidant
combination
Spermotrend®
for
three
months
on
semen
quality
in
infertile
men
with
at
least
one
abnormal
variable
analysis.
Eighty
were
randomized
between
2019
and
2022,
receiving
either
(n
=
40,
spermotrend-group)
or
placebo
placebo-group).
Although
a
total
80
patients
enrolled
study,
final
data
is
only
from
70
patients.
The
primary
outcome
measure
sperm
motility
(rapid
progressive,
motility).
values
secondary
outcomes
treatment
initiation
completion
compared
within
groups.
Moreover,
their
changes
placebo-
spermotrend-groups.
Sperm
rapid
progressive
significantly
increased
treated
(+1.0%,
95%
CI:
0.0
+2.0,
p
0.04),
while
this
increase
not
observed
placebo-group.
(+3.0%,
+15.1,
0.02),
Similarly,
DFI
decreased
by
(−3.2%,
−5.8
−0.5,
0.02).
However,
no
statistically
significant
differences
pre-
post-treatment
spermotrend-
placebo-group
regarding
motility,
concentration,
normal
morphology,
DFI,
formation
8-OH-dG.
appears
exert
limited
benefit
Biology,
Journal Year:
2025,
Volume and Issue:
14(5), P. 491 - 491
Published: May 1, 2025
Male
infertility
is
a
growing
global
concern,
with
asthenozoospermia
being
an
important
contributing
factor.
Mitochondrial
dysfunction
and
changes
in
the
metabolism
of
nitric
oxide
(NO)
are
key
determinants
reduced
sperm
motility.
This
study
investigates
effects
photobiomodulation
(PBM)
visible
near-infrared
(NIR)
laser
light
on
asthenozoospermic
patients,
focusing
mitochondrial
energetic
status,
oxidative
stress,
NO
dynamics.
Semen
samples
were
irradiated
at
450
nm,
635
810
940
1064
nm
different
power
levels
(0.25,
0.50,
1.00,
2.00
W)
for
60
s
spot
area
1
cm2.
ATP
AMP
levels,
stress
markers,
concentrations
assessed
10
min
after
irradiation,
ATP/AMP
ratio
calculated
as
index
cellular
energy
balance.
The
results
show
that
PBM
modulates
status
spermatozoa
way
dependent
wavelength
dose.
Irradiation
produced
most
marked
improvement
whereas
exposure
led
to
significant
decrease
levels.
showed
biphasic
response,
correlated
range
nm.
induced
higher
production
respect
other
wavelengths.
Our
findings
suggest
mainly
involves
photoreceptors
potentially
heme
flavin
groups
synthases,
facilitating
electron
transitions,
enhancing
effectiveness
phosphorylation,
optimizing
enzymatic
activity.
At
longer
wavelengths
(940
nm),
interactions
water
lipids
may
introduce
additional
variables
affect
membrane
fluidity
function
differently
from
shorter
