Inhalation Anesthetics Play a Janus-Faced Role in Self-Renewal and Differentiation of Stem Cells DOI Creative Commons

Xiaotong Hao,

Yuan Li,

Hairong Gao

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1167 - 1167

Published: Sept. 18, 2024

Inhalation anesthesia stands as a pivotal modality within clinical practices. Beyond its primary anesthetic effects, inhaled anesthetics have non-anesthetic exerting bidirectional influences on the physiological state of body and disease progression. These effects encompass impaired cognitive function, inhibition embryonic development, influence tumor progression, so forth. For many years, were viewed inhibitors stem cell fate regulation. However, there is now growing appreciation that promote biological functions thus are regarded double-edged sword affecting fate. In this review, self-renewal differentiation neural cells (NSCs), (ESCs), cancer (CSCs) summarized. The mechanisms involving cycle, metabolism, stemness, niche also discussed. A comprehensive understanding these will enhance our comprehension how impact human body, promising breakthroughs in development novel strategies for innovative therapy approaches.

Language: Английский

Promising applications of nanotechnology in inhibiting chemo-resistance in solid tumors by targeting epithelial-mesenchymal transition (EMT) DOI Open Access

Mona Tangsiri,

Ali Hheidari,

Mahsa Liaghat

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115973 - 115973

Published: Dec. 7, 2023

The resistance of cancer cells to chemotherapy, also known as chemo-resistance, poses a significant obstacle treatment and can ultimately result in patient mortality. Epithelial-mesenchymal transition (EMT) is one the many factors processes responsible for chemo-resistance. Studies have shown that targeting EMT help overcome nanotechnology nanomedicine emerged promising approaches achieve this goal. This article discusses potential inhibiting proposes viable strategy combat chemo-resistance various solid tumors, including breast cancer, lung pancreatic glioblastoma, ovarian gastric hepatocellular carcinoma. While has results EMT, further research necessary explore its full overcoming discovering more effective methods future.

Language: Английский

Citations

28
Mitochondrial dynamics and mitochondrial autophagy: Molecular structure, orchestrating mechanism and related disorders DOI Creative Commons
Haoran Wang, Wenjun Luo, Haoyu Chen

et al.

Mitochondrion, Journal Year: 2024, Volume and Issue: 75, P. 101847 - 101847

Published: Jan. 19, 2024

Mitochondrial dynamics and autophagy play essential roles in normal cellular physiological activities, while abnormal mitochondrial can cause cancer related disorders. Abnormal usually occur parallel with autophagy. Both have been reported to a synergistic effect therefore complement or inhibit each other. Progress has made understanding the classical PINK1/Parkin pathway dynamical abnormalities. Still, mechanisms regulatory pathways underlying interaction between mitophagy remain unexplored. Like other existing reviews, we review molecular structure of proteins involved autophagy, how their abnormalities lead development diseases. We will also individual effects leading proliferation, differentiation invasion. In addition, explore contribute targeted precise regulation function. Through study mechanisms, as well role early disease development, effective targets for function be proposed enable accurate diagnosis treatment associated

Language: Английский

Citations

17
Nanomedicine as a multimodal therapeutic paradigm against cancer: on the way forward in advancing precision therapy DOI
Puja Sandbhor, Pranoti Palkar, Sakshi Bhat

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(13), P. 6330 - 6364

Published: Jan. 1, 2024

Graphical representation of recent advancements in combinatorial anticancer treatment modalities.

Language: Английский

Citations

17
Macrophage’s role in solid tumors: two edges of a sword DOI Creative Commons

Arian Jahandideh,

Mahsa Yarizadeh,

Maryam Noei-Khesht Masjedi

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 31, 2023

Abstract The tumor microenvironment is overwhelmingly dictated by macrophages, intimately affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis, extracellular matrix reconfiguration, cellular proliferation, metastasis, and immunosuppression. They further exhibit resilience to chemotherapy immunotherapy via meticulous checkpoint blockades. When appropriately stimulated, macrophages can morph into a potent bidirectional component of the immune system, engulfing malignant cells annihilating them cytotoxic substances, thus rendering intriguing candidates for therapeutic targets. As myelomonocytic relentlessly amass within tissues, rise as prime contenders cell therapy upon development chimeric antigen receptor effector cells. Given significant incidence macrophage infiltration correlated an unfavorable prognosis heightened resistance solid we delve intricate role cancer propagation their promising potential confronting four formidable variants—namely, melanoma, colon, glioma, breast cancers.

Language: Английский

Citations

22
Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments DOI Creative Commons
Konstantinos Avgoustakis, Athina Angelopoulou

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 179 - 179

Published: Jan. 26, 2024

Solid tumors are composed of a highly complex and heterogenic microenvironment, with increasing metabolic status. This environment plays crucial role in the clinical therapeutic outcome conventional treatments innovative antitumor nanomedicines. Scientists have devoted great efforts to conquering challenges tumor microenvironment (TME), respect effective drug accumulation activity at site. The main focus is overcome obstacles abnormal vasculature, dense stroma, extracellular matrix, hypoxia, pH gradient acidosis. In this endeavor, nanomedicines that targeting distinct features TME flourished; these aim increase site specificity achieve deep penetration. Recently, research focused on immune reprograming order promote suppression cancer stem cells prevention metastasis. Thereby, several nanomedicine therapeutics which shown promise preclinical studies entered trials or already practice. Various novel strategies were employed trials. Among them, based biomaterials show improving efficacy, reducing side effects, promoting synergistic for responsive targeting. review, we mechanisms response solid tumors. We describe take advantage biomaterials’ properties exploit posed by TME. development such systems has significantly advanced application combinational therapies immunotherapies improved anticancer effectiveness.

Language: Английский

Citations

8
Applicability of Quantum Dots in Breast Cancer Diagnostic and Therapeutic Modalities—A State-of-the-Art Review DOI Creative Commons
Dominika Kunachowicz,

Karolina Kłosowska,

N. Sobczak

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(17), P. 1424 - 1424

Published: Aug. 31, 2024

The increasing incidence of breast cancers (BCs) in the world population and their complexity high metastatic ability are serious concerns for healthcare systems. Despite significant progress medicine made recent decades, efficient treatment invasive still remains challenging. Chemotherapy, a fundamental systemic method, is burdened with severe adverse effects, efficacy limited by resistance development risk disease recurrence. Also, current diagnostic methods have certain drawbacks, attracting attention to idea developing novel, more sensitive detection therapeutic modalities. It seems solution these issues can be provided nanotechnology. Particularly, quantum dots (QDs) been extensively evaluated as potential targeted drug delivery vehicles and, simultaneously, sensing bioimaging probes. These fluorescent nanoparticles offer unlimited possibilities surface modifications, allowing attachment biomolecules, such antibodies or proteins, molecules, among others. In this work, we discuss applicability QDs cancer diagnostics light knowledge. We begin introducing molecular histopathological features BCs, standard regimens, methods. Further, QDs, along uptake, biodistribution patterns, cytotoxicity, described. Based on reports published years, present research possible QD use improving BC chemotherapeutic photosensitizing agents, stages development. also address limitations open questions regarding topic.

Language: Английский

Citations

6
The impact of epithelial-mesenchymal transition (EMT) induced by metabolic processes and intracellular signaling pathways on chemo-resistance, metastasis, and recurrence in solid tumors DOI Creative Commons
Mahsa Liaghat,

Saeid Ferdousmakan,

Seyedeh Haniyeh Mortazavi

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 2, 2024

The intricate cellular process, known as the epithelial-mesenchymal transition (EMT), significantly influences solid tumors development. Changes in cell shape, metabolism, and gene expression linked to EMT facilitate tumor invasion, metastasis, drug resistance, recurrence. So, a better understanding of processes underlying its role growth may lead development novel therapeutic approaches for treatment tumors. This review article focuses on signals that promote intracellular signaling pathways leading EMT, network interactions between cancer metabolism. Furthermore, functions recurrence, metastasis cancers are covered. Lastly, focus networks metabolic alterations brought by will be discussed.

Language: Английский

Citations

4
Deep dissection of stemness-related hierarchies in hepatocellular carcinoma DOI Creative Commons
Rui Liang, Weifeng Hong, Yang Zhang

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 16, 2023

Increasing evidence suggests that hepatocellular carcinoma (HCC) stem cells (LCSCs) play an essential part in HCC recurrence, metastasis, and chemotherapy radiotherapy resistance. Multiple studies have demonstrated stemness-related genes facilitate the progression of tumors. However, mechanism by which contribute to is not well understood. Here, we aim construct a score (SRscores) model for deeper analysis genes, assisting with prognosis individualized treatment patients.Further, found gene LPCAT1 was highly expressed tumor tissues immunohistochemistry, sphere-forming assay revealed knockdown inhibited ability cells.We used TCGA-LIHC dataset screen from MSigDB database. Prognosis, microenvironment, immunological checkpoints, immune dysfunction, rejection, sensitivity, putative biological pathways were examined. Random forest created SRscores model. The anti-PD-1/anti-CTLA4 immunotherapy, mutational burden, medication cancer cell index compared between high- low-risk groups. We also examined risk scores different types using single-cell RNA sequencing data correlated transcription factor activity genes. Finally, tested core marker expression functions.Patients can be divided into two subtypes (Cluster1 Cluster2) based on dataset's identification 11 Additionally, developed subtypes. Cluster2 group lowest had superior survival immunotherapy response than Cluster1 highest SRscores. high significantly more enriched classical low factors are correlated. rat liver promotes sphere formation.A utilized predict patients as their immunotherapy.

Language: Английский

Citations

10
Autophagy induced by metabolic processes leads to solid tumor cell metastatic dormancy and recurrence DOI

Saeid Ferdousmakan,

Dorrin Mansourian,

Fatemeh Sadat Seyedi Asl

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(3)

Published: Feb. 3, 2025

Language: Английский

Citations

0
The Role of the Tumor Microenvironment in Tumor Progression and Response to Therapy DOI

Rafal Salim,

Watheq Mohammed AL-Jewari

Published: Jan. 1, 2025

The tumor microenvironment (TME) has emerged as a significant focus in cancer therapy due to its pivotal role controlling progression and shaping responses conventional treatments. This review explores recent innovations therapies targeting TME, including immunotherapies, antiangiogenic agents, treatments aimed at cancer-associated fibroblasts the extracellular matrix. These interventions, which are either approved for clinical use or undergoing trials, underscore TME's influence on treatment outcomes patient survival. identification of effective therapeutic strategies target TME is imperative mitigating immunosuppression, reactivating T cell functions, enhancing immune system efficacy. Notwithstanding advancements, key gaps persist comprehending intricate interactions within translating experimental findings into success. Future research should prioritize elucidating these enhance efficacy outcomes.

Language: Английский

Citations

0