Diabetes
and
diabetes-induced
micro
macrovascular
complications
are
major
causes
of
healthcare
problems.
The
extracellular
vesicles
produced
by
all
cells
from
organisms.
They
shown
to
have
properties
the
producer
also
reflect
host
physiology
pathology.
Since
EVs
represent
cellular
state
they
excellent
biomarkers.
In
this
review,
we
will
focus
on
Neuro
Vascular
Unit
eye
as
well
extraocular
in
onset
progression
diabetic
retinopathy.
A
brief
account
use
these
nanovesicles
personalised
medicine
is
given.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(12), P. 6640 - 6640
Published: June 17, 2024
Alzheimer's
disease
(AD)
and
type
2
diabetes
mellitus
(T2DM)
are
two
common
diseases
that
affect
the
elderly
population
worldwide.
The
identification
of
genes
associated
with
AD
T2DM
holds
promise
for
potential
biomarkers
intriguing
pathogenesis
these
complicated
diseases.
This
study
utilized
a
comprehensive
approach
by
integrating
transcriptome
data
from
multiple
cohorts,
encompassing
both
T2DM.
analysis
incorporated
various
types,
including
blood
tissue
samples
as
well
single-cell
datasets,
allowing
detailed
assessment
gene
expression
patterns.
From
brain
region-specific
analysis,
PIP4K2A,
which
encodes
phosphatidylinositol-5-phosphate
4-kinase
alpha,
was
found
to
be
expressed
mainly
in
oligodendrocytes
compared
other
cell
types.
Elevated
levels
PIP4K2A
patients'
were
key
cellular
processes
such
vesicle-mediated
transport,
negative
regulation
autophagosome
assembly,
cytosolic
transport.
PIP4K2A's
roles
offers
valuable
insights
into
development
diagnosis
therapy,
especially
complication
Diabetes
and
diabetes-induced
micro
macrovascular
complications
are
major
causes
of
healthcare
problems.
The
extracellular
vesicles
produced
by
all
cells
from
organisms.
They
shown
to
have
properties
the
producer
also
reflect
host
physiology
pathology.
Since
EVs
represent
cellular
state
they
excellent
biomarkers.
In
this
review,
we
will
focus
on
Neuro
Vascular
Unit
eye
as
well
extraocular
in
onset
progression
diabetic
retinopathy.
A
brief
account
use
these
nanovesicles
personalised
medicine
is
given.
