Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Cancer Biology & Therapy, Journal Year: 2025, Volume and Issue: 26(1)
Published: Jan. 26, 2025
Adaptive immune resistance in cancer describes the various mechanisms by which tumors adapt to evade anti-tumor responses. IFN-γ induction of programmed death-ligand 1 (PD-L1) was first defined and validated adaptive mechanism. The endoplasmic reticulum (ER) is central as modulatory secreted integral membrane proteins are dependent on ER. Sigma1 a unique ligand-regulated scaffolding protein enriched ER cells. PD-L1 an glycoprotein that translated into processed through cellular secretory pathway. At cell surface, checkpoint molecule binds PD-1 activated T-cells blocks immunity. can also be incorporated cell-derived extracellular vesicles (EVs), EV-associated inactivate within tumor microenvironment. Here, we demonstrate selective small inhibitor block mediated part altering incorporation EVs. inhibition blocked post-translational maturation downstream IFN-γ/STAT1 signaling. Subsequently, EVs released response stimulation were significantly less potent suppressors T-cell activation. These results suggest reducing derived suppressive EVs, may promote antitumor modulation presents novel approach regulating microenvironment content production Altogether, these data support notion play role
Language: Английский
Citations
2
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117897 - 117897
Published: Feb. 7, 2025
Language: Английский
Citations
2
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: March 1, 2024
Abstract Exosomes are nanoscale extracellular vesicles present in bodily fluids that mediate intercellular communication by transferring bioactive molecules, thereby regulating a range of physiological and pathological processes. can be secreted from nearly all cell types, the biological function exosomes is heterogeneous depends on donor type state. Recent research has revealed levels released endosomal system increase cells undergoing programmed death. These play crucial roles diseases, such as inflammation, tumors, autoimmune diseases. However, there currently lack systematic differences biogenesis, secretion mechanisms, composition under different death modalities. This review underscores potential vital mediators processes, highlighting interconnection between exosome biosynthesis regulatory mechanisms governing Furthermore, we accentuate prospect leveraging for development innovative biomarkers therapeutic strategies across various
Language: Английский
Citations
12
European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177236 - 177236
Published: Jan. 1, 2025
Language: Английский
Citations
1
Proteoglycan Research, Journal Year: 2025, Volume and Issue: 3(1)
Published: Jan. 1, 2025
ABSTRACT Alterations in glycoconjugate profiles are thought to promote changes cell‐to‐cell and cell‐to‐intracellular extracellular scaffold interactions human disease. The nearly unlimited number of “glycoforms” that may exist nature difficult study due glycosylation modifications being associated with non‐genome coded posttranscription post‐translation processes. Specific products generated by dependent on concentration sub‐cellular locations glycan synthesis processing enzymes. An indirect “high‐throughput” approach is characterize enzymes (hydrolases transferases) single cell sequencing all types tissue diseases. We previously identified TMEM230 as an endoplasmic reticulum (ER) protein regulates NOTCH glycoprotein receptor ligand signaling zebrafish blood vessel formation destructive remodeling capacities diverse including fibroblast, phagocytic immune system cells patients cancer or granulomatous systemic vasculitis autoimmune disorder. represents a paradigm mediated signal transduction supports the role modifications. ER initiates earliest steps synthesis, sorting, trafficking. As remodeling, Notch hallmarks disorders, we investigated whether aberrant expression was also rheumatoid arthritis (RA). In this current study, analysis supported downregulated synovial RA while were predominantly upregulated. contrast, upregulated high‐grade compared low‐grade gliomas it N‐linked (GlcNAc), glycosaminoglycan expression. Our collective results support glycan/glycoconjugate aggressive gliomas. therefore be therapeutic target marker for clinical treatment induced autoimmunity disorders cancer.
Language: Английский
Citations
1
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217639 - 217639
Published: March 1, 2025
Language: Английский
Citations
1
Journal of Biological Engineering, Journal Year: 2024, Volume and Issue: 18(1)
Published: June 6, 2024
Exosomes are nanovesicles with multiple components used in several applications. Mesenchymal stem cells (MSCs) well known for their great potential clinical MSC-derived exosomes (MSC-Exos) have been shown to mediate tissue regeneration various diseases, including neurological, autoimmune, and inflammatory cancer, ischemic heart disease, lung injury, liver fibrosis. They can modulate the immune response by interacting effector presence of anti-inflammatory compounds involved intercellular communication through types cargo. This review summarizes MSC-Exos-mediated cardiovascular, liver, kidney, articular cartilage, oral In addition, we discuss challenges prospects MSC-Exos regeneration.
Language: Английский
Citations
7
Cancers, Journal Year: 2024, Volume and Issue: 16(14), P. 2574 - 2574
Published: July 18, 2024
Extracellular vesicles, or EVs, are membrane-bound nanocompartments produced by tumor cells. EVs carry proteins and nucleic acids from host cells to target cells, where they can transfer lipids, proteomes, genetic material change the function of serve as reservoirs for mobile cellular signals. The collection using less invasive processes has piqued interest many researchers. Exosomes substances that suppress immune system. If results exosome screening negative, immunotherapy will be beneficial GC patients. In this study, we provide an update on based ongoing review papers clinical trials.
Language: Английский
Citations
5
MedComm, Journal Year: 2024, Volume and Issue: 5(12)
Published: Nov. 28, 2024
Abstract Extracellular vesicles (EVs) composed of various biologically active constituents, such as proteins, nucleic acids, lipids, and metabolites, have emerged a noteworthy mode intercellular communication. There are several categories EVs, including exosomes, microvesicles, apoptotic bodies, which largely differ in their mechanisms formation secretion. The amount evidence indicated that changes the EV quantity composition play role multiple aspects cancer development, transfer oncogenic signals, angiogenesis, metabolism remodeling, immunosuppressive effects. As isolation technology characteristics recognition improve, EVs becoming more commonly used early diagnosis evaluation treatment effectiveness for cancers. Actually, sparked clinical interest potential use delivery vehicles or vaccines innovative antitumor techniques. This review will focus on function biological molecules contained linked to progression participation intricate interrelationship within tumor microenvironment. Furthermore, efficacy an EV‐based liquid biopsy cargo be explored. Finally, we explicitly delineate limitations anticancer therapies provide overview trials aimed at improving development.
Language: Английский
Citations
4
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Non-small cell lung cancer (NSCLC) frequently metastasizes to the brain, significantly worsened prognoses. This study aimed develop an interpretable model for predicting survival in NSCLC patients with brain metastases (BM) integrating radiomic features and RNA sequencing data. 292 samples are collected analyzed utilizing T1/T2 MRIs. Bidirectional stepwise logistic regression is employed identify significant variables, facilitating construction of a prognostic model, which benchmarked against four machine learning algorithms. BM tissue processed extraction sequencing. The optimal achieved AUC 0.96 C-index 0.89 train set 0.84 0.78 test set, indicating strong predictive performance generalizability. Patients from Xiangya Hospital stratified into high-risk (n = 11) low-risk 30) groups. revealed enrichment immune-related pathways, particularly interferon (IFN) pathway group. Immune infiltration analysis identified presence CD8+-T cells, IFNγ-6/-18 group, suggesting immunologically favorable tumor microenvironment. These findings highlight potential combining data improved predictions personalized treatment strategies NSCLC.
Language: Английский
Citations
0