Hydrogen Sulfide (H2S) Generated in the Colon Induces Neuropathic Pain by Activating Spinal NMDA Receptors in a Rodent Model of Chronic Constriction Injury

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Jan. 30, 2025

Language: Английский

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Vagus nerve stimulation inhibits PANoptosis and promotes neurofunctional recovery of cerebral ischemic stroke in a Sirt1-dependent manner

Neurochemistry International, Journal Year: 2025, Volume and Issue: 184, P. 105950 - 105950

Published: Feb. 18, 2025

Language: Английский

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IRF1 and IL1A associated with PANoptosis serve as potential immune signatures for lung ischemia reperfusion injury following lung transplantation

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112739 - 112739

Published: July 28, 2024

Language: Английский

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Targeting the sigma-1 receptor with pridopidine induces functional neurorestoration in spinal cord ischemia-reperfusion injury

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

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Matrine alleviates Staphylococcus aureus-induced acute lung injury in mice by inhibiting MLKL and NLRP3-mediated inflammatory activity

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 993, P. 177385 - 177385

Published: Feb. 14, 2025

Language: Английский

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Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167782 - 167782

Published: March 1, 2025

Language: Английский

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Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Spinal cord ischemia-reperfusion injury (SCIRI) leads to severe neurological deficits, with pyroptosis emerging as a key driver of inflammation and neuronal death. Recent studies suggest that methyltransferase-like 3 (METTL3), critical RNA methyltransferase, may regulate the nucleotide-binding oligomerized structural domain-like receptor protein (NLRP3) inflammasome activation via N6-Methyladenosine (m6A) modification, yet direct evidence in SCIRI remains limited. This review synthesizes current knowledge on METTL3-NLRP3 axis pyroptosis, explores its therapeutic potential, identifies research gaps for future investigation.

Language: Английский

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Hydrogen Sulfide Sustained Release Donor Alleviates Spinal Cord Ischemia–Reperfusion‐Induced Neuron Death by Inhibiting Ferritinophagy‐Mediated Ferroptosis

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)

Published: March 1, 2025

ABSTRACT Aims Spinal cord ischemia–reperfusion injury (SCIRI) is a disastrous complication that cannot be completely prevented in thoracoabdominal aneurysm surgery, leading to sensory and motor dysfunction even paraparesis, causing tremendous socioeconomic burden. Ferritinophagy form of autophagic ferroptosis, which contributor SCIRI. Hydrogen sulfide (H 2 S) has been reported neuroprotective various diseases. However, it remains unclear whether H S alleviates SCIRI‐induced neural death via regulating ferritinophagy‐mediated ferroptosis. The aim this study was explore their relationship interaction Results results demonstrate Nissl bodies function were obviously lost SCIRI rats. Meanwhile, led significant increase DHE‐positive neurons, TUNEL‐positive LC3‐positive ferritin‐positive downregulation GPx4, Slc7a11, p62, ferritin expression, upregulation LC3 II/I NCOA4 expression. Additionally, there the level MDA, GSH, Fe 2+ . Finally, we found could significantly relieve neuronal loss rats by inhibiting ferritinophagy Conclusion Ferroptosis play crucial role etiopathogenesis SCIRI, exerts neuroprotection

Language: Английский

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Molecular mechanism of PANoptosis and programmed cell death in neurological diseases

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106907 - 106907

Published: April 1, 2025

PANoptosis represents a highly coordinated inflammatory programmed cell death governed by the assembly and activation of PANoptosome, which strategically integrate core molecular elements from pyroptosis, apoptosis, necroptosis. The triple-component pathways set themselves apart alternative regulated mechanisms through their unique capacity to concurrently process signals derived multiple death-signaling modalities, thereby coordinating multifaceted cellular defense system against diverse pathological insults. Pathogen-associated patterns synergistically interact with cytokine storms, oncogenic stress active PANoptosis, establishing this pathway as critical nexus in pathogenesis tumor immunomodulation. This crosstalk highlights promising therapeutic target for managing immune-related disorders malignant transformation. Emerging evidence links neuroinflammatory dysregulated between (apoptosis, necroptosis, pyroptosis) accidental necrosis, driving neuronal loss neural damage. Single-cell transcriptomics reveals spatially resolved signatures Alzheimer's hippocampal microenvironments sclerosis demyelinating plaques, distinct clusters correlating quantifiable metrics. PANoptosis-targeted therapies show preclinical promise alleviating neurovascular dysfunction while preserving physiological microglial surveillance functions. Accumulating linking (particularly PANoptosis) neurological underscores urgency deciphering its developing precision modulators next-generation therapies. review systematically deciphers PANoptosome associated cascades, evaluates roles multiscale regulatory networks, proposes frameworks advance neurology.

Language: Английский

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Identification of PANoptosis related biomarkers to predict hepatic ischemia‒reperfusion injury after liver transplantation

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 2, 2025

Language: Английский

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