Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101874 - 101874
Published: Nov. 24, 2024
Language: Английский
Published: July 22, 2024
Since its conception with the smallpox vaccination, worldwide-used vaccines have thwarted multiple pandemics including recent COVID-19 outbreak. Insightful studies uncovered complexities of different functional networks CD4 T cells [T helper 1 (Th1); Th2, Th17] and CD8 (T cytotoxic; Tc) as well B (BIgM, BIgG, BIgA BIgE) subsets during response to vaccination. Both cell forge central, peripheral tissue-resident It also became apparent that each vaccination formed network regulatory subsets, namely CD4+CD25+Foxp3+ (Treg) interleukin-10 (IL-10)-producing CD4+Foxp3− (Tr1) many others, are shaping quality/quantity vaccine-specific IgM, IgG, IgA antibody production. These components especially critical for immunocompromised patients, such older individuals allograft recipients, their may be ineffective or less effective. This review focuses on presenting how pre- post-vaccination Treg/Tr1 levels influence efficacy. Experimental clinical work revealed involvement evoked immune mechanisms in diminishing vaccine-induced cellular/humoral responses. Alternative steps considered improve by increasing a dose, changing delivery route and/or repeated booster doses vaccines. Vaccination combined anti-CD25 (IL-2Ra chain) anti-PD-1 (programmed death protein) monoclonal (mAb) decrease Tregs boost T/B response. All these data strategies immunizations presented discussed, aiming efficacy humans organ transplant patients.
Language: Английский
Citations
1
Published: Aug. 6, 2024
The immune response is crucial in Pregnancy Loss (RPL), which affects 1-2% of women. In RPL, peripheral blood lymphocytes and local cells are activated with a concomitant decrease the leukocyte tolerogenic uterus decidua. IL-17 plays an essential role T cell activation, weakening responses cells. report aims to analyze genetic polymorphism, circulating lymphocyte populations, reaction upon priming, amount cytokine serum, number T-reg group 50 RPL normal women from admixed Venezuelan population. No differences were observed polymorphisms rs2275913 rs763780. A significant (P<0.001) was patients compared controls IL-17+ populations CD3+, CD8+, CD56+, CD4CD25 FoxP3, but not CD4IL17+ priming significantly decreased all subpopulations as controls. It concluded that despite increase IL-17A serum patients, stimulation (p<0.001). polymorphism suggest biological factors influence levels must be carefully studied.
Language: Английский
Citations
1
Immuno, Journal Year: 2024, Volume and Issue: 4(4), P. 301 - 311
Published: Sept. 26, 2024
In recurrent pregnancy loss (RPL), peripheral and local immune cells are activated, decreasing the leukocyte tolerogenic response in uterus decidua. The aim was to examine role of IL-17 RPL critically. study included genetic polymorphism, analysis number circulating lymphocyte populations, before after cell priming, serum cytokine quantification, assessment T-reg a group 50 normal women from admixed Venezuelan population. found no differences polymorphisms rs2275913 rs763780. However, when IL-17+ populations controls patients were compared, significant increase observed CD3+ CD4+ (p < 0.001), while contrary recorded CD8+ CD56+ cells. Upon all significantly decreased 0.001) compared controls. IL-17A may be due population, exhaustion activation could responsible for CD4CD25 FoxP3+ reduced activated HLADR+ increased patients. absence polymorphism suggests that biological factors influence levels This finding has implications understanding potential treatment RPL.
Language: Английский
Citations
1
Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4134 - 4134
Published: Nov. 29, 2024
The etiology of gallbladder cancer (GBC) is multifactorial, with chronic inflammation resulting from infections, autoimmune diseases, and lifestyle factors playing a pivotal role. Vitamin D deficiency (VDD) has been implicated in the pathogenesis disorders various malignancies, including GBC. Research on diseases highlights anti-inflammatory properties vitamin D, suggesting its potential to mitigate disease progression. In oncology, VDD similarly linked increased inflammation, which may contribute both initiation progression cancer. A critical component carcinogenesis, as well immunomodulatory effects conditions, balance between T-helper 17 (Th17) cells regulatory T (Treg) cells. We hypothesize that inhibit epithelial–mesenchymal transition (EMT) GBC by modulating spatial distribution tumor-infiltrating cells, particularly through regulation Th17/Treg at tumor margins. This imbalance act mechanistic link carcinogenesis. Investigating role an mediator VDD-induced EMT not only provides deeper insights into but also sheds light broader mechanisms relevant development other solid organ cancers, given expanding recognition roles biology.
Language: Английский
Citations
1
Cytokine, Journal Year: 2024, Volume and Issue: 181, P. 156681 - 156681
Published: July 3, 2024
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 27, 2024
Background To effectively control tuberculosis (TB), it is crucial to distinguish between active TB disease and latent infection (LTBI) provide appropriate treatment. However, no such tests are currently available. Immune responses associated with LTBI dynamic exhibit distinct patterns. Comparing these differences for developing new diagnostic methods understanding the etiology of TB. This study aimed investigate relationship pro- anti-inflammatory CD4+ cytokine production following stimulation two types latency-associated Mycobacterium (M.tb) antigens allow differentiation LTBI. Methods Cryopreserved PBMCs from patients or were stimulated overnight replication-related antigen [ESAT-6/CFP-10 (E/C)] [heparin-binding hemagglutinin (HBHA) alpha-crystallin-like protein (Acr)]. Responses analyzed using multiparameter flow cytometry: (n=15), (n=15) ELISA: (n=26) (n=27). Results central memory T cells (Tcm) specific E/C effector Acr HBHA higher in than patients. IFN-γ+Tcm IL-17+ Tem was group (p= 0.012 p=0.029 respectively), but IL-10+ Tcm 0.029) stimulation. Additionally, HBHA, IL-10 significantly elevated compared those ( p = 0.0038), while cell IL-17 IFN-γ 0.0076, < 0.0001, respectively). also induced more CCR6+IL-17+CD4Tcells IL-17+FoxP3+CD25+CD4Tcells P =0.026 P=0.04, levels IFN-γ+IL-10+CD4+ (Pp=0.03) IFN-γ+IL-17+ (p=0.04). HBHA-specific measured ELISA showed participants (P=0.004) (P=0.04). Conclusion Stimulation measurement IFN-γ, IL-10, could potentially differentiate The characteristics cytokine-expressing by differed
Language: Английский
Citations
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Dermatology and Therapy, Journal Year: 2024, Volume and Issue: 14(10), P. 2827 - 2839
Published: Sept. 16, 2024
Psoriasis, a chronic, immune-mediated, inflammatory disease, affects 2‒3% of the population. Tyrosine kinase 2 (TYK2) mediates cytokine signaling involved in adaptive [interleukin (IL)-12, IL-23] and innate (type-I interferons) immune responses; IL-23-driven T-helper (Th)17 pathways play key role chronic inflammation psoriasis. In phase trial, deucravacitinib, an oral, selective, allosteric TYK2 inhibitor, reduced IL-23/Th17 type-I interferon pathway expression skin patients with moderate to severe plaque psoriasis, reductions that were accompanied by clinical improvement psoriatic lesions.
Language: Английский
Citations
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Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101874 - 101874
Published: Nov. 24, 2024
Language: Английский
Citations
0