International Journal of Medical Sciences,
Journal Year:
2024,
Volume and Issue:
21(14), P. 2664 - 2682
Published: Jan. 1, 2024
Breast
cancer
(BC)
is
the
most
common
among
women
globally
and
poses
leading
health
threat
to
worldwide,
with
persistently
high
incidence
rates.
Mitophagy
a
selective
autophagy
process
that
specifically
targets
mitochondria
within
cell,
maintaining
cellular
energy
balance
metabolic
by
identifying
degrading
damaged
mitochondria.
Although
there
an
understanding
of
relationship
between
mitophagy
cancer,
specific
mechanisms
remain
unclear
due
complexity
diversity
mitophagy,
suggesting
it
could
be
effective
more
targeted
therapeutic
approach
for
BC.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Oct. 21, 2024
Abstract
Breast
cancer
(BC)
currently
ranks
second
in
the
global
incidence
rate.
Hypoxia
is
a
common
phenomenon
BC.
Under
hypoxic
conditions,
cells
tumor
microenvironment
(TME)
secrete
numerous
extracellular
vesicles
(EVs)
to
achieve
intercellular
communication
and
alter
metabolism
of
primary
metastatic
tumors
that
shape
TME.
In
addition,
emerging
studies
have
indicated
hypoxia
can
promote
resistance
treatment.
Engineered
EVs
are
expected
become
carriers
for
treatment
due
their
high
biocompatibility,
low
immunogenicity,
drug
delivery
efficiency,
ease
modification.
this
review,
we
summarize
mechanisms
TME
distant
metastasis
BC
under
conditions.
Additionally,
highlight
potential
applications
engineered
mitigating
malignant
phenotypes
hypoxia.
International Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
156(5), P. 898 - 913
Published: Oct. 30, 2024
Exosomes
can
be
modified
and
designed
for
various
therapeutic
goals
because
of
their
unique
physical
chemical
characteristics.
Researchers
have
identified
tumor-derived
exosomes
(TEXs)
as
significant
players
in
cancer
by
influencing
tumor
growth,
immune
response
evasion,
angiogeneis,
drug
resistance.
TEXs
promote
the
production
specific
proteins
important
progression.
Due
to
easy
accessibility,
are
being
through
genetic,
delivery,
membrane,
system,
alterations
repurposed
vehicles
delivering
drugs
improve
treatment
outcomes.
In
complex
vivo
environment,
clustered
regularly
interspaced
short
palindromic
repeats
CRISPR-associated
protein
9
(CRISPR/Cas9)
system
encounters
challenges
from
degradation,
neutralization,
responses,
emphasizing
need
strategic
distribution
strategies
effective
genome
editing.
Engineered
present
a
promising
avenue
CRISPR/Cas9
vivo.
this
review,
we
will
explore
different
techniques
enhancing
using
engineering
strategies.
Additionally,
discuss
how
these
incorporated
into
advanced
genetic
systems
like
possible
uses.
Journal of Orthopaedic Surgery and Research,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Aug. 17, 2024
Osteosarcoma
(OS)
is
a
malignant
bone
tumor
that
commonly
occurs
in
children
and
adolescents
under
the
age
of
20.
Dysregulation
microRNAs
(miRNAs)
an
important
factor
occurrence
progression
OS.
MicroRNA
miR-744-5p
aberrantly
expressed
various
tumors.
However,
its
roles
molecular
targets
OS
remain
unclear.
International Journal of Medical Sciences,
Journal Year:
2024,
Volume and Issue:
21(14), P. 2664 - 2682
Published: Jan. 1, 2024
Breast
cancer
(BC)
is
the
most
common
among
women
globally
and
poses
leading
health
threat
to
worldwide,
with
persistently
high
incidence
rates.
Mitophagy
a
selective
autophagy
process
that
specifically
targets
mitochondria
within
cell,
maintaining
cellular
energy
balance
metabolic
by
identifying
degrading
damaged
mitochondria.
Although
there
an
understanding
of
relationship
between
mitophagy
cancer,
specific
mechanisms
remain
unclear
due
complexity
diversity
mitophagy,
suggesting
it
could
be
effective
more
targeted
therapeutic
approach
for
BC.
