BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences DOI
Sanad M. El-Khatib,

Arya R. Vagadia,

Anh C. D. Le

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive dysfunction (RICD). RICD significantly impacts quality life cancer survivors, highlighting an unmet medical need. Previous human studies revealed a marked reduction in plasma brain-derived neurotrophic factor (BDNF) post-chronic chemotherapy, linking this decline to substantial among survivors. Moreover, riluzole (RZ)-mediated increased BDNF

Language: Английский

Cognitive dysfunction induced by cranial radiotherapy: mechanisms and therapeutic methods DOI Creative Commons
Xuejiao Li, Zhongxiang Ding

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: unknown, P. 111106 - 111106

Published: Oct. 1, 2024

Language: Английский

Citations

1
BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences DOI Creative Commons
Sanad M. El-Khatib,

Arya R. Vagadia,

Anh C. D. Le

et al.

Acta Neuropathologica Communications, Journal Year: 2024, Volume and Issue: 12(1)

Published: Dec. 18, 2024

Language: Английский

Citations

1
SCF/C-kit drives spermatogenesis disorder induced by abscopal effects of cranial irradiation in mice DOI Creative Commons
Ling Guo,

Tongzhou Qin,

Xing Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116504 - 116504

Published: May 24, 2024

Cranial radiotherapy is a major treatment for leukemia and brain tumors. Our previous study found abscopal effects of cranial irradiation could cause spermatogenesis disorder in mice. However, the exact mechanisms are not yet fully understood. In study, adult male C57BL/6 mice were administrated with 20 Gy X-ray (5 per day 4 days consecutively) sacrificed at 1, 2 weeks. Tandem Mass Tag (TMT) quantitative proteomics testis was combined bioinformatics analysis to identify key molecules signal pathways related weeks after irradiation. GO showed that closely oxidative stress inflammation. Severe occurred testis, serum brain, while serious inflammation also serum. Additionally, sex hormones hypothalamic-pituitary-gonadal (HPG) axis disrupted. PI3K/Akt pathway activated which upstream molecule SCF/C-Kit significantly elevated. Furthermore, proliferation differentiation ability spermatogonial stem cells (SSCs) altered. These findings suggest can through brain-blood-testicular cascade stress, secretory dysfunction HPG axis, SCF/C-kit drive this process activating pathway.

Language: Английский

Citations

0
Adjunctive clozapine with bright light mitigates cognitive deficits by synaptic plasticity and neurogenesis in sub-chronic MK-801 treated mice DOI
Lizhi Zhang,

Yiying Zhou,

Yanhong Xie

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: 243, P. 173821 - 173821

Published: July 11, 2024

Language: Английский

Citations

0
BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences DOI
Sanad M. El-Khatib,

Arya R. Vagadia,

Anh C. D. Le

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive dysfunction (RICD). RICD significantly impacts quality life cancer survivors, highlighting an unmet medical need. Previous human studies revealed a marked reduction in plasma brain-derived neurotrophic factor (BDNF) post-chronic chemotherapy, linking this decline to substantial among survivors. Moreover, riluzole (RZ)-mediated increased BDNF

Language: Английский

Citations

0