A Comprehensive Analysis of the Cuproptosis-Related Gene GCSH in Pan-Cancer with a Focus on Colorectal Cancer DOI Creative Commons
Xianwen Guo,

Rong-e Lei,

Jiao Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Background GCSH, a gene associated with cuproptosis, has been implicated in various cancers, although its role remains incompletely understood. This study aims to conduct comprehensive analysis of GCSH across multiple cancer types elucidate tumorigenesis. Methods expression was analyzed 33 using data from TCGA database. Associations the tumor microenvironment and prognostic value were evaluated. scRNA-seq colorectal (CRC) used assess different cell types. Clinical CRC tissues, blood samples, lines utilized for validation. Functional assays drug sensitivity tests performed further GCSH. Results varied among notably higher levels CRC. demonstrated significant correlations 22 immune cells cancers. Generally, showed negative correlation scores checkpoint genes. Prognostic revealed that outcomes adrenocortical carcinoma, hepatocellular stomach adenocarcinoma, external cohort results did not consistently support these findings. Validation clinical samples confirmed elevated indicated both cancerous within tissues compared normal tissues. pathway analyses identified key biological roles identified. Conclusions exerts multifaceted specific cancers is significantly The identifies functions suggests potential sensitivities.

Language: Английский

Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases DOI
Zhibo Yang,

Ridong Feng,

Zhao Hai

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(9-10), P. 1330 - 1360

Published: July 16, 2024

Language: Английский

Citations

12
Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy DOI
Yuanying Yang, Chen Dong, Xuehua Ma

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.

Language: Английский

Citations

1
Wilson’s Disease—Crossroads of Genetics, Inflammation and Immunity/Autoimmunity: Clinical and Molecular Issues DOI Open Access
Grażyna Gromadzka,

Julia Czerwińska,

Elżbieta Krzemińska

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 9034 - 9034

Published: Aug. 20, 2024

Wilson's disease (WD) is a rare, autosomal recessive disorder of copper metabolism caused by pathogenic mutations in the

Language: Английский

Citations

5
PER2 interaction with HSP70 promotes cuproptosis in oral squamous carcinoma cells by decreasing AKT stability DOI Creative Commons
Wenguang Yu,

Shilin Yin,

Hong Tang

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 20, 2025

Abstract Oral squamous cell carcinoma (OSCC) has a poor prognosis, with unclear mechanisms posing challenge for the development of effective treatment strategies. Cuproptosis is novel death mode that disrupts mitochondrial metabolism. Clarifying regulate cuproptosis may provide important new insights to guide OSCC treatment. Here, we found biological clock gene Period2 ( PER2 ) was under-expressed in OSCC, consequent inhibition cellular cuproptosis, whereas it overexpression vitro and vivo promoted cuproptosis. Mechanistically, bound heat shock protein 70 (HSP70) through its C-terminal domain, subsequently reducing interaction between HSP70 AKT leading enhanced degradation ubiquitination, promoting cells by inhibiting pathway upregulating DLAT, PDHB, SLC31A1 expression. Activating transcription factor 3 (ATF3) an upstream regulator , binds −807 −796 bp site promoter. Overexpression ATF3 dependent on transcriptional activation promotes cells. The anti-tumor effect inducer 1-targeted upregulation combined copper ionophore elesclomol (ES) be significantly compared monotherapy xenograft model. These findings reveal critical role ATF3-dependent regulation development, suggesting targeted or combination induce as strategy potentially improve prognosis patients.

Language: Английский

Citations

0
Cuproptosis and its potential role in musculoskeletal disease DOI Creative Commons
Zijian Xiang, Heng Mei, Honglin Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 11, 2025

Cuproptosis, a recently identified form of copper-dependent cell death, arises from intracellular copper dyshomeostasis. As an essential trace element, plays critical role in bioenergetic metabolism, redox regulation, and synaptic transmission. However, excessive exerts cytotoxic effects through multiple pathways, including increased reactive oxygen species (ROS) production, apoptotic cascade activation, necrotic membrane rupture, inflammatory responses, mitochondrial dysfunction. Distinct other death mechanisms, cuproptosis is characterized by ion binding to acetylated respiratory chain proteins, leading pathogenic protein aggregation, iron-sulfur cluster depletion, cellular collapse. Emerging evidence underscores aberrant accumulation resultant proteotoxic stress as pivotal contributors the pathogenesis musculoskeletal pathologies, osteoporosis, osteoarthritis, sarcopenia, osteosarcoma, intervertebral disc degeneration, spinal cord injury, biofilm-associated orthopedic infections. Understanding spatiotemporal regulation may provide novel opportunities for advancing diagnostic therapeutic approaches medicine. This review synthesizes current insights into molecular mechanisms cuproptosis, its diseases, potential biomarker-driven interventions.

Language: Английский

Citations

0
Neutrophil extracellular traps in tumor metabolism and microenvironment DOI Creative Commons

Z. Liu,

Yuanyao Dou, Conghua Lu

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 23, 2025

Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array physiological pathological activities, including immune rheumatic diseases damage to target organs. Recently, the connection between NETs cancer has garnered significant attention. Within tumor microenvironment metabolism, exhibit multifaceted roles, such as promoting proliferation migration cells, influencing redox balance, triggering angiogenesis, driving metabolic reprogramming. This review offers comprehensive analysis link emphasizing areas that remain underexplored. include interaction with mitochondria, their effect on states within tumors, involvement reprogramming, contribution angiogenesis tumors. Such insights lay theoretical foundation for deeper understanding role development. Moreover, also delves into potential therapeutic strategies suggests future research directions, offering new perspectives treatment other related diseases.

Language: Английский

Citations

0
Advances in non-apoptotic regulated cell death: implications for malignant tumor treatment DOI Creative Commons
Yizheng Zhang,

Shiqi Yi,

Mingyuan Luan

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 30, 2025

Cell death mechanisms are broadly classified into accidental cell (ACD) and regulated (RCD). ACD such as necrosis, is an uncontrolled, process, while RCD tightly by specific signaling pathways molecular mechanisms. Tumor cells characterized their ability to evade sustain uncontrolled proliferation. The failure of programmed a key contributor tumor initiation, progression, resistance cancer therapies. Traditionally, research has focused primarily on apoptosis the dominant form in cancer. However, emerging evidence highlights importance other non-apoptotic forms RCD, pyroptosis, ferroptosis, necroptosis, parthanatos, tumorigenesis treatment response. These gaining attention for potential roles overcoming therapy resistance. In this review, we will discuss recent advances study malignant tumors explore therapeutic implications, offering insights new targets strategies.

Language: Английский

Citations

0
Cell death in tumor microenvironment: an insight for exploiting novel therapeutic approaches DOI Creative Commons

Wenxin Wang,

Tong Li, Kui Wu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 10, 2025

Abstract Cell death is critical in tumor biology. The common cancer therapies can cause cell and alleviate tumor, while the cells develop a resistance to survive from therapies. Thus, not only observing alternative mechanisms of resistant death, but also understanding intricate dynamics processes within microenvironment (TME), are essential for tailoring effective therapeutic strategies. High-throughput sequencing technologies have revolutionized research by enabling comprehensive molecular profiling. Recent advances single unraveled heterogeneity TME components, shedding light on their complex interactions. In this review, we explored interplay between signaling TME, summarised potential drugs inducing pre-clinical stage, reviewed some studies applying next-generation research, discussed future utilization updated platforms screening novel treatment methods targeted death. conclusion, leveraging multi-omics dissect context holds great promise advancing therapy development.

Language: Английский

Citations

0
Biodegradable ionic nanoregulators for synchronous modulation of copper and iron ion homeostasis in breast cancer therapy DOI

P. Xue,

Huilan Zhuang,

Sijie Shao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162041 - 162041

Published: April 1, 2025

Language: Английский

Citations

0
Cinobufagin treatments suppress tumor growth by enhancing the expression of cuproptosis-related genes in liver cancer DOI
Mandana AmeliMojarad, Melika AmeliMojarad, Parvin Shariati

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Language: Английский

Citations

3