Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 8 - 8

Published: Jan. 1, 2025

Each year, the number of cases strokes and deaths due to this is increasing around world. This could be work stress, lifestyles, unhealthy food habits, several other reasons. Currently, there are traditional methods like thrombolysis mechanical thrombectomy for managing strokes. The current approach has limitations, delayed diagnosis, limited therapeutic delivery, risks secondary injuries. So, a need some effective reliable management strokes, which help in early diagnosis followed by treatment Nanotechnology played an immense role recently, it emerged as transformative solution offering innovative diagnostic tools strategies. Nanoparticles (NPs) belonging classes, including metallic (metallic metal oxide), organic (lipids, liposome), carbon, can cross blood–brain barrier may exhibit potential various Moreover, these NPs have exhibited promise improving imaging specificity delivery precise drug real-time monitoring efficacy. Nanomaterials cerium oxide (CeO2) liposome-encapsulated agents neuroprotective properties that reduce oxidative stress promote neuroregeneration. In present article, authors emphasized significant advancements nanomedicine stroke, NPs-based systems, neuroregenerative therapies, multimodal advancements.

Language: Английский

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The Effect of Adipose-Derived Stem Cell (ADSC)-Exos on the Healing of Autologous Skin Grafts in Miniature Pigs

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 479 - 479

Published: Jan. 8, 2025

The skin functions as the body's primary defense barrier; when compromised, it can lead to dehydration, infection, shock, or potentially life-threatening conditions. Miniature pigs exhibit characteristics and healing processes highly analogous humans. Mesenchymal stem cells contribute injury repair through a paracrine mechanism involving exosomes. This research examines whether adipose-derived MSC exosomes effectively enhance following autologous grafting in miniature pigs. It also compares roles distinctions of ADSCs ADSC-Exos inflammatory responses tissue regeneration. study found significantly reduced levels oxidative stress products pro-inflammatory factors, while antioxidant anti-inflammatory pro-regenerative factors were elevated, anti-regenerative factor decreased. Moreover, expression key markers-namely, PI3K, Akt, mTOR-in regeneration-associated signaling pathway increased. alterations these indicators indicate that regulate promote provides novel theoretical foundation for implementation acellular therapy clinical settings.

Language: Английский

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Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Ischemic Stroke: A Meta-Analysis of Preclinical Studies

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111219 - 111219

Published: Jan. 1, 2025

Ischemic stroke (IS) remains a significant global health burden, necessitating the development of novel therapeutic strategies. This study aims to systematically evaluate effects mesenchymal stem cell-derived exosomes (MSC-Exos) on IS outcomes in rodent models. A comprehensive literature search was conducted across multiple databases identify studies investigating MSC-Exos models IS. Following rigorous inclusion and exclusion criteria, 73 high-quality were selected for meta-analysis. Primary included reductions infarct volume/ratio improvements functional recovery scores. Data extraction analysis performed using RevMan 5.3 software. Pooled data indicated that administration significantly reduced size improved scores Treatment within 24hours beyond induction both demonstrated substantial compared controls. Furthermore, MSC-Exos-treated groups exhibited marked recovery, as assessed by various neurobehavioral tests. The meta-analysis showed no publication bias, heterogeneity levels acceptable. reveal potential IS, with evidence supporting their efficacy reducing enhancing preclinical These findings pave way further research clinical translation.

Language: Английский

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Calycosin Inhibit PANoptosis and Alleviate Brain Damage: A Bioinformatics and Experimental Verification Approach

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

PANoptosis is a newly identified form of cell death that encompasses pyroptosis, apoptosis, and necroptosis. Numerous studies have highlighted the significance in brain ischemia-reperfusion (I/R) injury. Calycosin, natural product with diverse biological activities, has demonstrated significant reduction neuronal caused by ischemic injury modulating multiple pathways. In order to investigate potential mechanisms underlying neuroprotective role calycosin alleviating PANoptosis-induced damage stroke therapy, we used mouse hippocampal line HT22 stimulate ischemia vitro through Oxygen Glucose Deprivation/Reperfusion (OGD/R) established molecular docking assess binding affinity Calycosin key targets dynamics simulations (MDS) study stability ligand-protein complex. The results demonstrate could improve growth HT22, leading enhanced viability, reduced lactate dehydrogenase leakage, decreased apoptosis after OGD/R. It also regulated expression PANoptosis-related genes such as NLRP3, GSDMD, MLKL, RIPK1 increased Bcl-2/Bax ratio, effectively reducing cellular providing protection. Molecular MDS strong activity between targets. Furthermore, successfully passed drug similarity (DS) evaluation exhibited favorable absorption, distribution, metabolism, excretion, toxicity (ADMET) properties activity. conclusion, alleviate inhibiting PANoptosis, inflammation improving Thus, it serve therapy for stroke.

Language: Английский

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Research progress of traditional Chinese medicine in the treatment of ischemic stroke by regulating mitochondrial dysfunction

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123045 - 123045

Published: Sept. 7, 2024

Language: Английский

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Exosomes in Central Nervous System Diseases: A Comprehensive Review of Emerging Research and Clinical Frontiers

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1519 - 1519

Published: Nov. 27, 2024

Exosomes, nano-sized lipid bilayer vesicles, have garnered significant attention as mediators of cell communication, particularly within the central nervous system (CNS). Their unique properties, including high stability, low immunogenicity, and ability to traverse blood-brain barrier (BBB), position them promising tools for understanding addressing CNS diseases. This comprehensive review delves into biogenesis, composition, functions, isolation exosomes, with a particular focus on their roles in cerebrovascular diseases, neurodegenerative disorders, tumors. Exosomes are involved key pathophysiological processes CNS, angiogenesis, inflammation, apoptosis, cellular microenvironment modification. They demonstrate promise mitigating ischemic injury, regulating inflammatory responses, providing neuroprotection across various conditions. Furthermore, exosomes carry distinct biomolecules, offering novel method early diagnosis monitoring Despite potential, challenges such complex extraction processes, heterogeneity exosomal contents, targeted delivery limitations hinder clinical application. Nevertheless, hold advancing our diseases developing therapeutic strategies. manuscript significantly contributes field by highlighting exosomes’ potential underscoring value strategies mediating communication.

Language: Английский

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Unveiling synergies: Integrating TCM herbal medicine and acupuncture with conventional approaches in stroke management

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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