Localized Drug Delivery in Different Gastrointestinal Cancers: Navigating Challenges and Advancing Nanotechnological Solutions

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 741 - 770

Published: Jan. 1, 2025

Different types of cancers affect the gastrointestinal tract (GIT), starting from oral cavity and extending to colon. In general, most current research focuses on systemic delivery therapeutic agents, which leads undesired side effects a limited enhancement in outcomes. As result, localized within (GI) is favorable overcoming these limitations. However, via administration faces many challenges related complex structure GIT (varied pH levels transit times) as well harsh environment tumor cells (hypoxia, efflux pumps, acidity). To overcome obstacles, nano-drug systems (NDDs) have been designed proved their potential by exploiting favor offering specific desired target. The review begins with an overview different GI impact globally. Then, it discusses treatment approaches corresponding Additionally, associated drug for are summarized. Finally, detail recent diagnostic applications NDDs that conducted oral, esophageal, gastric, colon, liver cancers, aiming offer valuable insights into future state utilizing local cancers.

Language: Английский

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Membrane drug transporters in cancer: From chemoresistance mechanism to therapeutic strategies

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189272 - 189272

Published: Jan. 23, 2025

Language: Английский

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CD44-Targeted nanoparticles for remodeling the tumor microenvironment in a 3D Macrophage-Embedded ovarian cancer model with stem Cell-Like features

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125483 - 125483

Published: March 1, 2025

Language: Английский

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Ligand-receptor pair-based signature score Derived from On-treatment Tumor Specimens Predicts Immune Checkpoint Blockade Response in Metastatic Melanoma

Published: April 17, 2025

Immune checkpoint blockade (ICB) therapy has transformed the treatment landscape for metastatic melanoma, yet predicting therapeutic response remains a significant challenge. This study hypothesizes that coordinated ligand-receptor (LR) interactions within tumor microenvironment (TME) critically influence ICB efficacy and proposes novel LR pair-based signature score (LRPS) derived from on-treatment samples can predict clinical outcomes. Using transcriptomic data five independent cohorts, we identified seven pairs (FLT3-FLT3LG, LY9-LY9, CD5-CD5, CD40LG-ITGA2B/ITGB3, APP-CD74, TNFRSF17-TNFSF13, FCER2-ITGAV/ITGB3) significantly associated with LRPS demonstrated predictive power, achieving an area under curve (AUC) exceeding 0.8 in four cohorts. Based on signature, subjects were divided into high- low-scores groups using mean score. rates higher high-scoring cohort than low-scoring subjects. Patient high scores tended to have better survival outcomes did those low scores. In conclusion, verified provides theoretical basis applying such signatures responses therapies.

Language: Английский

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Transforming treatment paradigms: Focus on personalized medicine for high‐grade serous ovarian cancer

CA A Cancer Journal for Clinicians, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of cancer, accounting for approximately 70% all cases contributing significantly to high mortality rates associated with this disease. Because asymptomatic nature early stage disease, patients are diagnosed at advanced stages when has already spread into abdominal cavity, requiring complex intensive surgical chemotherapeutic interventions followed by maintenance therapies. Although a minority well defined genetic syndromes, specific risk factors clear etiology in many remain elusive. HGSOC tumors characterized frequency somatic gene copy number alterations, often defects homologous recombination repair DNA. All attempts introduce an effective screening date have been unsuccessful. This review elucidates complexities surrounding encompasses its etiology, epidemiology, classification, pathogenesis, current array treatment strategies. Understanding molecular underpinnings crucial development targeted therapies personalized multimodal approaches centralized therapeutic structures. also examines importance tumor microenvironment. In addition, authors' objective underscore critical placing patient's perspective diversity forefront strategies, thereby fostering genuinely participatory decision‐making process ultimately improving patient quality life.

Language: Английский

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Single-cell RNA sequencing reveals key signaling pathways and biological functions in giant cell tumors of bone

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 19, 2025

Language: Английский

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Human Tendon‐on‐a‐Chip for Modeling the Myofibroblast Microenvironment in Peritendinous Fibrosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Nov. 15, 2024

Understanding the myofibroblast microenvironment is critical to developing therapies for fibrotic diseases. Here development of a novel human tendon-on-a-chip (hToC) reported model this crosstalk in peritendinous adhesions, which currently lacks biological therapies. The hToC facilitates cellular and paracrine interactions between vascular component, contains endothelial cells monocytes, tissue hydrogel component that houses tendon macrophages. It found replicates some aspects vivo inflammatory phenotypes preclinical clinical samples, including activated mTOR signaling, inflammation, contraction induced by activation, cytokines secretion, transendothelial migration monocytes hydrogel. Transcriptional analysis demonstrates significant overlap enriched pathways with tenolysis activation signaling. Rapamycin suppresses inflammation phenotype hToC, provides proof-of-concept its utility as an vitro tool investigating multicellular fibrosis testing therapeutics mitigate it.

Language: Английский

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Gut Microbiota–microRNA Interactions and Obesity Pathophysiology: A Systematic Review of Integrated Studies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12836 - 12836

Published: Nov. 29, 2024

Obesity is the fifth leading cause of death globally and its comorbidities put a high burden on societies disability. In this review, we aim to summarize interactions crosstalk between gut microbiota micro-RNA (miRNA) in obesity. We searched for relevant literature through PubMed, Web Science, Scopus, Science Direct. The study design registered international prospective register systematic reviews (Prospero). According inclusion criteria, eight studies were eligible assessment (two including human subjects six animal subjects). report that miRNA context obesity are diverse some cases tissue specific. However, mediate obesity-associated pathways inflammatory response, oxidative stress, insulin signaling, permeability, lipogenesis. To mention most meaningful results, expression adipose miRNA-378a-3p/5p was associated with

Language: Английский

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Development of resistance to anticancer medications: Challenges and clinical implications

Side effects of drugs annual, Journal Year: 2024, Volume and Issue: unknown, P. 517 - 530

Published: Jan. 1, 2024

Language: Английский

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