Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: June 8, 2020

On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking pandemic of acute respiratory syndrome humans (COVID-19). the 24th April 2020, number COVID-19 deaths world, according to COVID-Case Tracker by Johns Hopkins University, was 195,313, and confirmed cases 2,783,512. The represents massive impact on human health, causing sudden lifestyle changes, through social distancing isolation at home, with economic consequences. Optimizing public health during this requires not only knowledge from medical biological sciences, but also all sciences related lifestyle, behavioural studies, including dietary habits lifestyle.Our study aimed investigate immediate eating changes among Italian population aged ≥ 12 years. comprised structured questionnaire packet that inquired demographic information (age, gender, place residence, current employment); anthropometric data (reported weight height); (adherence Mediterranean diet, daily intake certain foods, food frequency, meals/day); (grocery shopping, habit smoking, sleep quality physical activity). survey conducted 5th 2020.A total 3533 respondents have been included study, between 86 years (76.1% females). perception gain observed 48.6% population; 3.3% smokers decided quit smoking; slight increased activity has reported, especially for bodyweight training, 38.3% respondents; group 18-30 resulted having higher adherence diet when compared younger elderly (p < 0.001; p 0.001, respectively); 15% turned farmers or organic, purchasing fruits vegetables, North Center Italy, where BMI values were lower.In we provided first time Diet pattern lockdown. However, as is ongoing, our need be investigated future more extensive studies.

Language: Английский

---

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

Molecular Cell, Journal Year: 2020, Volume and Issue: 78(6), P. 1019 - 1033

Published: June 1, 2020

Language: Английский

---

Dietary modifications for enhanced cancer therapy

Nature, Journal Year: 2020, Volume and Issue: 579(7800), P. 507 - 517

Published: March 25, 2020

Language: Английский

---

Obesity: A preventable, treatable, but relapsing disease

Nutrition, Journal Year: 2019, Volume and Issue: 71, P. 110615 - 110615

Published: Oct. 17, 2019

Language: Английский

---

Analysis of the Impact of the Confinement Resulting from COVID-19 on the Lifestyle and Psychological Wellbeing of Spanish Pregnant Women: An Internet-Based Cross-Sectional Survey

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(16), P. 5933 - 5933

Published: Aug. 15, 2020

(1) Background: This study aimed to analyze the impact of confinement due COVID-19 pandemics on eating, exercise, and quality-of-life habits pregnant women. (2) Methods: was an internet-based cross-sectional survey which collected information about adherence Mediterranean diet, physical health-related quality life (HRQoL), perceived obstacles (in terms preparation for delivery, medical appointments) women before after confinement. The conducted in 18-31 May 2020. (3) Results: A total 90 participated this study. There a significant decrease levels activity (p < 0.01) as well HRQoL 0.005). number hours spent sitting increased by 50% 0.001), 52.2% were unable attend delivery sessions because these had been cancelled. However, there no differences eating pattern = 0.672). Conclusions: These results suggest need implement specific online programs promote exercise reduce stress, thus improving population, should similar confinements occur again any reason future.

Language: Английский

---

Role of Personalized Nutrition in Chronic-Degenerative Diseases

Nutrients, Journal Year: 2019, Volume and Issue: 11(8), P. 1707 - 1707

Published: July 24, 2019

Human nutrition is a branch of medicine based on foods biochemical interactions with the human body. The phenotypic transition from health to disease status can be attributed changes in genes and/or protein expression. For this reason, new discipline has been developed called “-omic science”. In review, we analyzed role “-omics sciences” (nutrigenetics, nutrigenomics, proteomics and metabolomics) as possible therapeutic tool chronic degenerative diseases. particular, focused nutrigenetics relationship between eating habits, DNA sequence onset nutrition-related Moreover, examined nutrigenomics effect nutrients gene We perused metabolomics personalized nutrition. scenario, also how dysbiosis gut microbiota influence progression influencing regulating activity, both directly indirectly, paves way for that plays key prevention treatment

Language: Английский

---

Advancing to the era of cancer immunotherapy

Cancer Communications, Journal Year: 2021, Volume and Issue: 41(9), P. 803 - 829

Published: June 24, 2021

Cancer greatly affects the quality of life humans worldwide and number patients suffering from it is continuously increasing. Over last century, numerous treatments have been developed to improve survival cancer but substantial progress still needs be made before can truly cured. In recent years, antitumor immunity has become most debated topic in research booming development immunotherapy led a new epoch therapy. this review, we describe relationships between tumors immune system, rise immunotherapy. Then, summarize characteristics tumor-associated immunotherapeutic strategies with various molecular mechanisms by showing typical molecules whose antibodies are broadly used clinic those that under investigation. We also discuss important elements individual cells whole human body, including cellular mutations modulation, metabolic reprogramming, microbiome, contexture. addition, present observations technical advancements both diagnostic therapeutic methods aimed at Lastly, controversies challenges negatively impact patient outcomes.

Language: Английский

---

The Mediterranean Diet: An Update of the Clinical Trials

Nutrients, Journal Year: 2022, Volume and Issue: 14(14), P. 2956 - 2956

Published: July 19, 2022

The Mediterranean Diet (MedDiet) is a term used to identify dietary pattern originating from the unique multi-millennial interplay between natural food resources and eating practices of people living in basin. Scientific evidence has described healthy properties MedDiet its beneficial role several pathological conditions. Nevertheless, current socio-economic trends have moved away this lifestyle. Thus, clinical biological supporting benefits needed overcome these limitations. Clinical nutrition research examines effects interventions on or health-related outcomes determined study population. produced by studies useful for guidance public health messaging. We provided an update trials registered database clinicaltrials.gov evaluating specific diseases. Our findings revealed increased number last decade found that most disease-related focused cardiovascular diseases, metabolic cancer. majority MedDiet’s could be primarily related anti-inflammatory anti-oxidant as well effectiveness controlling waist circumference obesity. Moreover, strict long-lasting adherence components (e.g., olive oil polyphenols) seem emerge insights interventional improvements. These present further into how it strengthen overall health.

Language: Английский

---

High-salt diet mediates interplay between NK cells and gut microbiota to induce potent tumor immunity

Science Advances, Journal Year: 2021, Volume and Issue: 7(37)

Published: Sept. 10, 2021

High-salt diet (HSD) modulates effector and regulatory T cell functions promotes tissue inflammation in autoimmune diseases. However, effects of HSD its association with gut microbiota tumor immunity remain undefined. Here, we report that induces natural killer (NK) cell–mediated by inhibiting PD-1 expression while enhancing IFNγ serum hippurate. Salt enhanced when combined a suboptimal dose anti-PD1 antibody. While HSD-induced was blunted upon depletion, fecal transplantation (FMT) from mice restored the associated NK functions. increased abundance Bifidobacterium caused permeability leading to intratumor localization Bifidobacterium, which regression. Intratumoral injections activated cells, inhibited growth. These results indicate microbiome cell–dependent potential translational perspective.

Language: Английский

---

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 11, 2024

Abstract Diet, serving as a vital source of nutrients, exerts profound influence on human health and disease progression. Recently, dietary interventions have emerged promising adjunctive treatment strategies not only for cancer but also neurodegenerative diseases, autoimmune cardiovascular metabolic disorders. These demonstrated substantial potential in modulating metabolism, trajectory, therapeutic responses. Metabolic reprogramming is hallmark malignant progression, deeper understanding this phenomenon tumors its effects immune regulation significant challenge that impedes eradication. Dietary intake, key environmental factor, can tumor metabolism. Emerging evidence indicates might affect the nutrient availability tumors, thereby increasing efficacy treatments. However, intricate interplay between pathogenesis other diseases complex. Despite encouraging results, mechanisms underlying diet-based remain largely unexplored, often resulting underutilization management. In review, we aim to illuminate various interventions, including calorie restriction, fasting-mimicking diet, ketogenic protein restriction high-salt high-fat high-fiber aforementioned diseases. We explore multifaceted impacts these encompassing their immunomodulatory effects, biological impacts, molecular mechanisms. This review offers valuable insights into application therapies

Language: Английский

---