International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(9), P. 5142 - 5142
Published: May 5, 2022
The
skin,
oral
cavity,
digestive
and
reproductive
tracts
of
the
human
body
harbor
symbiotic
commensal
microorganisms
living
harmoniously
with
host.
cavity
houses
one
most
heterogeneous
microbial
communities
found
in
organism,
ranking
second
terms
species
diversity
complexity
only
to
gastrointestinal
microbiota
including
bacteria,
archaea,
fungi,
viruses.
accumulation
plaque
may
lead,
susceptible
individuals,
a
complex
host-mediated
inflammatory
immune
response
representing
primary
etiological
factor
periodontal
damage
that
occurs
periodontitis.
Periodontal
disease
is
chronic
condition
affecting
about
20–50%
people
worldwide
manifesting
clinically
through
detection
gingival
inflammation,
clinical
attachment
loss
(CAL),
radiographic
assessed
resorption
alveolar
bone,
pockets,
bleeding
upon
probing,
teeth
mobility
their
potential
advanced
stages.
This
review
will
evaluate
changes
characterizing
healthy
tissues
those
affected
by
evidence
present
literature.
An
important
focus
be
placed
on
immediate
future
impact
these
modulation
dysbiotic
microbiome
management
disease.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: Feb. 23, 2021
The
past
decade
has
witnessed
groundbreaking
advances
in
the
field
of
microbiome
research.
An
area
where
immense
implications
have
been
demonstrated
is
tumor
biology.
affects
initiation
and
progression
through
direct
effects
on
cells
indirectly
manipulation
immune
system.
It
can
also
determine
response
to
cancer
therapies
predict
disease
survival.
Modulation
be
harnessed
potentiate
efficacy
immunotherapies
decrease
their
toxicity.
In
this
review,
we
comprehensively
dissect
recent
evidence
regarding
interaction
anti-tumor
machinery
outline
critical
questions
which
need
addressed
as
further
explore
dynamic
colloquy.
Diagnostics,
Journal Year:
2021,
Volume and Issue:
11(7), P. 1283 - 1283
Published: July 16, 2021
The
human
oral
microbiome
refers
to
an
ecological
community
of
symbiotic
and
pathogenic
microorganisms
found
in
the
cavity.
cavity
is
environment
that
provides
various
biological
niches,
such
as
teeth,
tongue,
mucosa.
gateway
between
external
body,
maintaining
homeostasis,
protecting
mouth,
preventing
disease.
On
flip
side,
also
plays
important
role
triggering,
development,
progression
systemic
diseases.
In
recent
years,
disease
diagnosis
through
analysis
has
been
realized
with
development
innovative
detection
technology
overwhelmingly
promising
compared
previous
era.
It
patients
diseases
have
variations
their
normal
subjects.
This
narrative
review
insight
into
pathophysiological
influencing
furthers
knowledge
related
produced
over
past
30
years.
A
wide
range
updates
were
provided
latest
help
researchers
clinicians
both
academic
clinical
aspects.
microbial
information
can
be
utilized
non-invasive
develop
a
new
paradigm
precision
medicine,
which
will
benefit
health
era
post-metagenomics.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Aug. 10, 2022
The
incidence
of
hyperuricemia
(HUA)
and
gout
continuously
increases
has
become
a
major
public
health
problem.
gut
microbiota,
which
colonizes
the
human
intestine,
mutually
beneficial
symbiotic
relationship
with
host
plays
vital
role
in
host’s
metabolism
immune
regulation.
Structural
changes
or
imbalance
microbiota
could
cause
metabolic
disorders
participate
synthesis
purine-metabolizing
enzymes
release
inflammatory
cytokines,
is
closely
related
to
occurrence
development
disease
HUA
gout.
as
an
entry
point
explore
pathogenesis
new
research
hotspot.
This
review
summarizes
characteristics
patients
Meanwhile,
influence
different
dietary
structures
on
effect
purine
uric
acid
metabolism,
internal
between
endotoxemia/inflammatory
factors
are
explored.
Moreover,
intervention
effects
probiotics,
prebiotics,
fecal
microbial
transplantation
also
systematically
reviewed
provide
flora
solution
for
prevention
treatment
diseases.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(3), P. 866 - 866
Published: Jan. 30, 2023
Colorectal
cancer
(CRC)
is
the
second-leading
cause
of
cancer-related
deaths
worldwide.
While
CRC
thought
to
be
an
interplay
between
genetic
and
environmental
factors,
several
lines
evidence
suggest
involvement
gut
microbiota
in
promoting
inflammation
tumor
progression.
Gut
refer
~40
trillion
microorganisms
that
inhabit
human
gut.
Advances
next-generation
sequencing
technologies
metagenomics
have
provided
new
insights
into
microbial
ecology
helped
linking
CRC.
Many
studies
carried
out
humans
animal
models
emphasized
role
certain
bacteria,
such
as
Fusobacterium
nucleatum,
enterotoxigenic
Bacteroides
fragilis,
colibactin-producing
Escherichia
coli,
onset
progression
Metagenomic
opened
up
avenues
for
application
diagnosis,
prevention,
treatment
This
review
article
summarizes
development
its
use
a
biomarker
predict
disease
potential
therapeutic
applications.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Feb. 11, 2025
The
oral
microbiome
comprises
over
700
distinct
species,
forming
complex
biofilms
essential
for
maintaining
and
systemic
health.
When
the
microbial
homeostasis
in
periodontium
is
disrupted,
pathogens
within
biofilm
can
cause
periodontitis
peri-implantitis,
inducing
host
immune
responses.
Understanding
role
of
communities
mechanisms
health
disease
crucial
developing
improved
preventive,
diagnostic
therapeutic
strategies.
However,
many
questions
remain
about
how
changes
bacterial
populations
contribute
to
development
progression
these
conditions.
An
electronic
manual
literature
search
was
conducted
using
PubMed,
Excerpta
Medica,
Frontiers
Reports
Wiley
Online
Library
databases
relevant
articles.
Data
from
publications
were
extracted
overall
findings
summarized
a
narrative
manner.
variations
responses
peri-implantitis
are
explored.
Dysbiosis
subgingival
microbiome—characterized
by
an
increase
pathogenic
bacteria
such
as
Porphyromonas
gingivalis
,
Tannerella
forsythia
Aggregatibacter
actinomycetemcomitans
—plays
pivotal
initiation
periodontitis.
As
alterations
include
higher
abundance
opportunistic
reduced
diversity
around
implants.
Moreover,
dysbiosis
potentially
influencing
through
immune-mediated
pathways.
Regional
immunity
involving
neutrophils,
T
helper
cells-17,
immune-related
cytokines
periodontal
responding
imbalances.
Additionally,
impact
non-mechanical
treatments—such
probiotics
laser
therapy—on
discussed,
demonstrating
their
potential
managing
dysbiosis.
These
underscore
that
central
factor
peri-implantitis.
Maintaining
balance
preventing
diseases,
interventions
targeting
could
enhance
treatment
outcomes.
Strategies
focusing
on
controlling
bacteria,
modulating
responses,
promoting
tissue
regeneration
key
restoring
stability.
Further
research
needed
clarify
underlying
transition
peri-implant
mucositis
optimize
prevention
approaches,
considering
interactions
between
immunity.
Clinical Cancer Research,
Journal Year:
2019,
Volume and Issue:
26(6), P. 1474 - 1485
Published: Dec. 17, 2019
Patients
with
head
and
neck
squamous
cell
carcinoma
(HNSCC)
who
actively
smoke
during
treatment
have
worse
survival
compared
never-smokers
former-smokers.
We
hypothesize
the
poor
prognosis
in
tobacco
smokers
HNSCC
is,
at
least
part,
due
to
ongoing
suppression
of
immune
response.
characterized
tumor
microenvironment
(TIM)
a
retrospective
cohort
177
current,
former,
never
smokers.Tumor
specimens
were
subjected
analysis
CD3,
CD8,
FOXP3,
PD-1,
PD-L1,
pancytokeratin
by
multiplex
immunofluorescence,
whole-exome
sequencing,
RNA
sequencing.
Immune
markers
measured
core,
margin,
stroma.Our
data
indicate
that
current
significantly
lower
numbers
CD8+
cytotoxic
T
cells
PD-L1+
TIM
never-
While
mutation
burden
mutant
allele
heterogeneity
score
do
not
associate
smoking
status,
gene-set
enrichment
analyses
reveal
significant
IFNα
IFNγ
response
pathways
smokers.
Gene
expression
canonical
IFN
chemokines,
CXCL9,
CXCL10,
CXCL11,
are
than
former
smokers,
suggesting
mechanism
for
decreased
migration
sites.These
results
suggest
active
use
has
an
immunosuppressive
effect
through
inhibition
infiltration
cells,
likely
as
result
pathways.
Our
study
highlights
importance
understanding
interaction
between
light
emerging
modulators
cancer
management.
Gastroenterology report,
Journal Year:
2021,
Volume and Issue:
10
Published: Nov. 10, 2021
Human
gut-microbiome
explorations
have
enriched
our
understanding
of
microbial
colonization,
maturation,
and
dysbiosis
in
health-and-disease
subsets.
The
enormous
metabolic
potential
gut
microbes
their
role
the
maintenance
human
health
is
emerging,
with
new
avenues
to
use
them
as
therapeutic
agents
overcome
disorders.
Microbiome
therapeutics
are
aimed
at
engineering
microbiome
using
additive,
subtractive,
or
modulatory
therapy
an
application
native
engineered
microbes,
antibiotics,
bacteriophages,
bacteriocins.
This
approach
could
limitation
conventional
by
providing
personalized,
harmonized,
reliable,
sustainable
treatment.
Its
huge
economic
has
been
shown
global
market.
Despite
economical
potential,
still
developing
stage
facing
various
technical
administrative
issues
that
require
research
attention.
review
aims
address
current
knowledge
landscape
therapeutics,
provides
overview
existing
applications,
discusses
future
directions
modulations.
Scientific Reports,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: March 26, 2021
Abstract
Dietary
fiber
functions
as
a
prebiotic
to
determine
the
gut
microbe
composition.
The
microbiota
influences
metabolic
and
immune
responses
in
human
health.
metabolites
produced
by
various
dietary
components
not
only
modulate
immunity
but
also
impact
organs.
Although
recent
findings
have
suggested
that
microbial
dysbiosis
is
associated
with
several
respiratory
diseases,
including
asthma,
cystic
fibrosis,
allergy,
role
of
nutrients
respect
pulmonary
disease
remains
unclear.
Therefore,
we
explored
whether
could
influence
cigarette
smoking
(CS)-exposed
emphysema
model.
In
this
study,
it
was
demonstrated
high-fiber
diet
non-fermentable
cellulose
fermentable
pectin
attenuated
pathological
changes
progression
inflammatory
response
CS-exposed
mice.
Moreover,
observed
different
types
diversity
differentially
impacted
anabolism
generation
short-chain
fatty
acids,
bile
sphingolipids.
Overall,
results
study
indicate
diets
play
beneficial
microbiota-metabolite
modulation
substantially
affect
Furthermore,
suggests
therapeutic
potential
from
via
local
systemic
inflammation
inhibition,
which
may
be
useful
development
new
COPD
treatment
plan.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(21), P. 8061 - 8061
Published: Oct. 29, 2020
Oral
squamous
cell
carcinoma
(OSCC)
is
one
of
the
leading
presentations
head
and
neck
cancer
(HNC).
The
first
part
this
review
will
describe
highlights
oral
microbiome
in
health
normal
development
while
demonstrating
how
both
gut
can
map
OSCC
development,
progression,
treatment
potential
side
effects
associated
with
its
management.
We
then
scope
dynamics
various
microorganisms
cavity,
including
bacteria,
mycoplasma,
fungi,
archaea
viruses,
characteristic
roles
they
may
play
development.
also
highlight
human
immunodeficiency
viruses
(HIV)
impinge
on
host
increase
burden
premalignant
lesions
patients
HIV.
Finally,
we
summarise
current
insights
into
microbiome-treatment
axis
pertaining
to
OSCC,
show
affected
by
radiotherapy,
chemotherapy,
immunotherapy
these
therapies
are
state
microbiome,
potentially
determining
success
or
failure
some
treatments.
